A5044254377- RNA Interference and Gene Delivery
- Atherosclerosis and Cardiovascular Diseases
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- interferon and immune responses
- Cardiovascular Disease and Adiposity
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- RNA and protein synthesis mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 and COVID-19 Research
- Immune cells in cancer
- Food Allergy and Anaphylaxis Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- RNA modifications and cancer
Sichuan University
2022-2025
West China Hospital of Sichuan University
2022-2024
State Key Laboratory of Biotherapy
2023-2024
It is urgent to develop more effective mRNA vaccines against the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants owing immune escape. Here, we constructed a novel delivery system [IC8/Mn lipid nanoparticles (IC8/Mn LNPs)]with high immunogenicity, via introducing stimulator of interferon genes (STING) agonist [manganese (Mn)] based on newly synthesized ionizable (IC8). was found that Mn can not only promote maturation antigen-presenting cells activating STING...
Efficient translation mediated by the 5' untranslated region (5' UTR) is essential for robust efficacy of mRNA vaccines. However,
<title>Abstract</title> Given the rising incidence of allergic asthma, current symptomatic treatments primarily offer relief rather than halt disease progression. Recombinant allergens, designed with reduced immunoglobulin E (IgE) reactivity and ability to regulate excessive T helper type 2 (Th2) responses, are emerging as promising candidates for more precise, effective, safer specific immunotherapy (SIT). SIT remains only clinical approach capable potentially curing certain diseases by...