A5053752264- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Advanced Proteomics Techniques and Applications
- Polymer Surface Interaction Studies
- 3D Printing in Biomedical Research
- Cell Adhesion Molecules Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Immunotherapy and Immune Responses
- Protease and Inhibitor Mechanisms
- Nanoparticles: synthesis and applications
- Immune Cell Function and Interaction
- Dendrimers and Hyperbranched Polymers
- Monoclonal and Polyclonal Antibodies Research
- Biosensors and Analytical Detection
- Microfluidic and Capillary Electrophoresis Applications
- Electrohydrodynamics and Fluid Dynamics
- Lipid Membrane Structure and Behavior
- MicroRNA in disease regulation
King Abdulaziz University
2014-2025
Codexis (United States)
2024
Brigham and Women's Hospital
2013-2022
Harvard University
2013-2022
Massachusetts Institute of Technology
2006-2020
Robert Bosch (Germany)
2020
Francophone University Association
2020
National University of Singapore
2020
Laboratoire de Chimie Moléculaire et Thioorganique
2020
Tehran University of Medical Sciences
2017
Nanotechnology is the understanding and control of matter generally in 1–100 nm dimension range. The application nanotechnology to medicine, known as nanomedicine, concerns use precisely engineered materials at this length scale develop novel therapeutic diagnostic modalities.1,2 Nanomaterials have unique physicochemical properties, such ultra small size, large surface area mass ratio, high reactivity, which are different from bulk same composition. These properties can be used overcome some...
Targeted uptake of therapeutic nanoparticles in a cell-, tissue-, or disease-specific manner represents potentially powerful technology. Using prostate cancer as model, we report docetaxel (Dtxl)-encapsulated formulated with biocompatible and biodegradable poly( d , l -lactic- co -glycolic acid)- block -poly(ethylene glycol) (PLGA- b -PEG) copolymer surface functionalized the A10 2′-fluoropyrimidine RNA aptamers that recognize extracellular domain prostate-specific membrane antigen (PSMA),...
The application of nanotechnology in medicine, referred to as nanomedicine, is offering numerous exciting possibilities healthcare. Herein, we discuss two important aspects drug delivery and tissue engineering, highlighting the advances have recently experienced, challenges are currently facing, what likely witness near future.
Enhanced permeability of the tumor vasculature allows macromolecules to enter interstitial space, whereas suppressed lymphatic filtration them stay there. This phenomenon, enhanced and retention (EPR), has been basis nanotechnology platforms deliver drugs tumors. However, progress in developing effective using this approach hampered by heterogeneity EPR effect different tumors limited experimental data from patients on effectiveness mechanism as related drug accumulation. report summarizes...
A targeted nanoparticle containing docetaxel displays antitumor activity in animals and differentiated pharmacological properties patients with advanced solid tumors.
We report a novel quantum dot (QD)−aptamer(Apt)−doxorubicin (Dox) conjugate [QD−Apt(Dox)] as targeted cancer imaging, therapy, and sensing system. By functionalizing the surface of fluorescent QD with A10 RNA aptamer, which recognizes extracellular domain prostate specific membrane antigen (PSMA), we developed imaging system (QD−Apt) that is capable differential uptake cells express PSMA protein. The intercalation Dox, widely used antineoplastic anthracycline drug properties, in...
Cisplatin is used to treat a variety of tumors, but dose limiting toxicities or intrinsic and acquired resistance limit its application in many types cancer including prostate. We report unique strategy deliver cisplatin prostate cells by constructing Pt(IV)-encapsulated prostate-specific membrane antigen (PSMA) targeted nanoparticles (NPs) poly(D,L-lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-functionalized controlled release polymers. By using PLGA-b-PEG with PSMA targeting...
We report the engineering of a novel lipid−polymer hybrid nanoparticle (NP) as robust drug delivery platform, with high encapsulation yield, tunable and sustained release profile, excellent serum stability, potential for differential targeting cells or tissues. The NP comprises three distinct functional components: (i) hydrophobic polymeric core where poorly water-soluble drugs can be encapsulated; (ii) hydrophilic shell antibiofouling properties to enhance stability systemic circulation...
Nucleic acid ligands (aptamers) are potentially well suited for the therapeutic targeting of drug encapsulated controlled release polymer particles in a cell- or tissue-specific manner. We synthesized bioconjugate composed nanoparticles and aptamers examined its efficacy targeted delivery to prostate cancer cells. Specifically, we poly(lactic acid)-block-polyethylene glycol (PEG) copolymer with terminal carboxylic functional group (PLA-PEG-COOH), rhodamine-labeled dextran (as model drug)...
A central challenge in the development of drug-encapsulated polymeric nanoparticles is inability to control mixing processes required for their synthesis resulting variable nanoparticle physicochemical properties. Nanoparticles may be developed by and nanoprecipitation polymers drugs dissolved organic solvents with nonsolvents. We used rapid tunable through hydrodynamic flow focusing microfluidic channels poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) diblock copolymers as a model...
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release drugs. Despite nearly three decades research, approaches to reproducibly formulate NPs with optimal biophysicochemical properties have remained elusive. A central challenge defining interplay parameters that confer molecular targeting, immune evasion, drug overcome physiological barriers vivo. Here, we report a strategy narrowly changing...