A5041411617- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Radiation Therapy and Dosimetry
- Prostate Cancer Treatment and Research
- 3D Printing in Biomedical Research
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Advanced biosensing and bioanalysis techniques
- Radiopharmaceutical Chemistry and Applications
- Quantum Dots Synthesis And Properties
- CAR-T cell therapy research
- Colorectal Cancer Surgical Treatments
- Graphene and Nanomaterials Applications
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Head and Neck Cancer Studies
University of North Carolina at Chapel Hill
2016-2025
The University of Texas Southwestern Medical Center
2021-2025
Carolina Institute for NanoMedicine
2013-2025
Southwestern Medical Center
2022-2025
Duke Medical Center
2025
Duke University
2024-2025
National Cancer Institute
2025
University of Toronto
2022-2024
New York University
2024
SUNY Downstate Health Sciences University
2024
Nanotechnology is the understanding and control of matter generally in 1–100 nm dimension range. The application nanotechnology to medicine, known as nanomedicine, concerns use precisely engineered materials at this length scale develop novel therapeutic diagnostic modalities.1,2 Nanomaterials have unique physicochemical properties, such ultra small size, large surface area mass ratio, high reactivity, which are different from bulk same composition. These properties can be used overcome some...
We report the engineering of a novel lipid−polymer hybrid nanoparticle (NP) as robust drug delivery platform, with high encapsulation yield, tunable and sustained release profile, excellent serum stability, potential for differential targeting cells or tissues. The NP comprises three distinct functional components: (i) hydrophobic polymeric core where poorly water-soluble drugs can be encapsulated; (ii) hydrophilic shell antibiofouling properties to enhance stability systemic circulation...
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release drugs. Despite nearly three decades research, approaches to reproducibly formulate NPs with optimal biophysicochemical properties have remained elusive. A central challenge defining interplay parameters that confer molecular targeting, immune evasion, drug overcome physiological barriers vivo. Here, we report a strategy narrowly changing...
It has long been hypothesized that elastic modulus governs the biodistribution and circulation times of particles cells in blood; however, this notion never rigorously tested. We synthesized hydrogel microparticles with tunable elasticity physiological range, which resemble red blood size shape, tested their behavior vivo. Decreasing these altered properties, allowing them to bypass several organs, such as lung, entrapped more rigid counterparts, resulting increasingly longer well past those...
Inflammation-triggered combination delivery of anti-PD-1 antibody and CpG oligodeoxynucleotides (CpG ODNs) has been demonstrated to prevent cancer relapse utilizing postsurgical inflammatory response. The controlled release anti-PD1 ODN by DNA-based "nano-cocoons" can induce considerable immune response, which in turn significantly prolongs the survival time mice. As a service our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed...
Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to thermally stable nanoparticle, have demonstrated that bioconjugates can detect cells with high sensitivity specificity. Furthermore, the be used deliver targeted chemotherapy. Supporting information this article is available on WWW under http://www.wiley-vch.de/contents/jc_2452/2008/z800091_s.pdf or from...
Conventional photodynamic therapy (PDT)'s clinical application is limited by depth of penetration light. To address the issue, we have recently developed X-ray induced (X-PDT) which utilizes as an energy source to activate a PDT process. In addition breaking shallow tissue dogma, our studies found more efficient tumor cell killing with X-PDT than radiotherapy (RT) alone. The mechanisms behind cytotoxicity, however, not been elucidated. present study, investigate action on cancer cells. Our...
Combination immunotherapy has recently emerged as a powerful cancer treatment strategy. A promising approach utilizes coadministration of antagonistic antibodies to block checkpoint inhibitor receptors, such antiprogrammed cell death-1 (aPD1), alongside agonistic activate costimulatory antitumor necrosis factor receptor superfamily member 4 (aOX40). Optimal T-cell activation is achieved when both immunomodulatory agents simultaneously engage T-cells and promote synergistic proactivation...
An ongoing effort in the field of nanomedicine is to develop nanoplatforms with both imaging and therapeutic functions, "nanotheranostics". We have previously developed a human serum albumin (HSA) coated iron oxide nanoparticle (HINP) formula used multiple modalities validate its tumor targeting attributes. In current study, we sought impart doxorubicin (Dox) onto HINPs assess potential conjugates as theranostic agents. typical preparation, found that about 0.5 mg Dox 1 nanoparticles (IONPs,...