A5100412482- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Photoacoustic and Ultrasonic Imaging
- Advanced Nanomaterials in Catalysis
- Cancer, Hypoxia, and Metabolism
- Graphene and Nanomaterials Applications
- Photodynamic Therapy Research Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Luminescence and Fluorescent Materials
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Bacteriophages and microbial interactions
- Biosensors and Analytical Detection
- Iron oxide chemistry and applications
- Virus-based gene therapy research
- Nanocluster Synthesis and Applications
- Autophagy in Disease and Therapy
- Iron Metabolism and Disorders
Xiamen University
2016-2025
Chinese Academy of Sciences
2012-2025
Qingdao Agricultural University
2023-2025
North Sichuan Medical University
2007-2025
Dalian Medical University
2019-2025
Shanghai East Hospital
2010-2025
Chinese PLA General Hospital
2011-2025
Southern Medical University
2009-2025
Nanfang Hospital
2009-2025
Guangxi Medical University
2020-2025
A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection WS2-PEG. In treatment then conducted a mouse model, achieving excellent therapeutic efficacy with complete ablation tumors. This work promises further exploration transition-metal dichalcogenides for biomedical applications, such as cancer and therapy. As service to our...
Despite the ubiquity of ferrihydrite in natural sediments and its importance as an industrial sorbent, nanocrystallinity this iron oxyhydroxide has hampered accurate structure determination by traditional methods that rely on long-range order. We uncovered atomic arrangement real-space modeling pair distribution function (PDF) derived from direct Fourier transformation total x-ray scattering. The PDF for synthesized with use different routes is consistent a single phase (hexagonal space...
Multifunctional nanocomposites have the potential to integrate sensing, diagnostic, and therapeutic functions into a single nanostructure. Herein, we synthesize Fe3O4@polydopamine core–shell (Fe3O4@PDA NCs) through an in situ self-polymerization method. Dopamine, melanin-like mimic of mussel adhesive proteins, can self-polymerize form surface-adherent polydopamine (PDA) films onto wide range materials including Fe3O4 nanoparticles used here. In such nanocomposites, PDA provides number...
Enormous efforts have been made toward the translation of nanotechnology into medical practice, including cancer management. Generally applications fallen two categories: diagnosis and therapy. Because targets are often same, development separate approaches can miss opportunities to improve efficiency effectiveness.The unique physical properties nanomaterials enable them serve as basis for superior imaging probes locate report cancerous lesions vehicles deliver therapeutics preferentially...
Uniform plasmonic Pd@Au core–shell bimetallic nanoplates are synthesized by seeded growth strategy. Surface modified with SH-PEG makes it good biocompatibility, prolonged blood circulation, and relatively high tumor accumulation. Enhanced contrast effects can be obtained for in vivo photoacoustic/CT imaging after intravenous injection of Pd@Au-PEG. Moreover, efficient photothermal ablation is achieved, guided the techniques. This work promises further exploration superiority 2D...
The development of precision nanomedicines to direct nanostructure-based reagents into tumour-targeted areas remains a critical challenge in clinics. Chemical reaction-mediated localization response tumour environmental perturbations offers promising opportunities for rational design effective nano-theranostics. Here, we present unique microenvironment-sensitive strategy peptide-premodified upconversion nanocrystals (UCNs) within areas. Upon tumour-specific cathepsin protease reactions, the...
Ag2S nanoparticles are increasingly important in biomedicine, such as cancer imaging. However, there has been only limited success the exploration of theranostic for photoinduced imaging and simultaneous therapy. Here we report size-dependent nanodots (NDs) with well-defined nanostructure a agent multimodal photothermal The NDs precisely synthesized through carefully controlled growth hollow human serum albumin nanocages. These produce effective fluorescence second near-infrared (NIR-II)...
The emergence of photoluminescent carbon-based nanomaterials has shown exciting potential in the development benign nanoprobes. However, vivo kinetic behaviors these particles that are necessary for clinical translation poorly understood to date. In this study, fluorescent carbon dots (C-dots) were synthesized and effect three injection routes on their fate was explored by using both near-infrared fluorescence positron emission tomography imaging techniques. We found C-dots efficiently...
Ultrasound (US)-driven sonodynamic therapy (SDT) has demonstrated wide application prospects in the eradication of deep-seated bacterial infections due to its noninvasiveness, site-confined irradiation, and high-tissue-penetrating capability. However, ineffective accumulation sonosensitizers at infection site, hypoxic microenvironment, as well rapid depletion oxygen during SDT greatly hamper therapeutic efficacy SDT. Herein, an US-switchable nanozyme system was proposed for controllable...
It is essential to control the size and morphology of nanoparticles strictly in nanomedicine. Protein cages offer significant potential for templated synthesis inorganic nanoparticles. In this study, we successfully synthesized ultrasmall copper sulfide (CuS) inside cavity ferritin (Fn) nanocages by a biomimetic method. The uniform CuS–Fn (CuS–Fn NCs) showed strong near-infrared absorbance high photothermal conversion efficiency. quantitative ratiometric photoacoustic imaging (PAI), NCs...
The combination of gold and copper is a good way to pull down the cost ameliorate instability copper. Through shape control, synergy these two metals can be better exploited. Here, we report an aqueous phase route synthesis pentacle gold-copper alloy nanocrystals with fivefold twinning, size which tuned in range from 45 200 nm. growth found start decahedral core, followed by protrusion branches along twinning planes. Pentacle products display strong localized surface plasmon resonance peaks...
Many photoresponsive dyes have been utilized as imaging and photodynamic/photothermal therapy agents. Indocyanine green (ICG) is the only near-infrared region (NIR) organic dye for clinical applications approved by United States Food Drug Administration; however, application of ICG limited its poor aqueous solubility, low cancer specificity, sensitivity in theranostics. To overcome these issues, a multifunctional nanoplatform based on hyaluronic acid (HA) ICG-engineered metal-organic...
Smart cyanine-grafted gadolinium oxide nanocrystals (Cy-GdNCs) obtained by albumin-based biomineralization are shown to be theranostic nanocomposites, with promising properties for trimodal near-infrared fluorescence/photoacoustics/magnetic-resonance imaging-guided photothermal tumor ablation.
Monodisperse Gd2O3-embedded iron oxide (GdIO) nanoparticles can simultaneously enhance the local magnetic field intensities of each other under an external and result in synergistic enhancement T1 T2 effects. GdIO have unique property to be both contrast agents potentially lead higher accuracy cancer diagnosis, particularly liver tumors.
Photodegradation of rhodamine B in the presence H2O2 by visible light over α-Fe2O3 architectures has been investigated (see picture; left to right: 1D nanorods, 2D nanoplates, 3D nanocubes). A link between exposed facets and their photoreactivity is established, following {110}>{012}≫{001}. Structure–reactivity correlations are a central theme heterogeneous catalysis.1–4 In general, crystallographic surface structure catalyst determined its facets, enclosed particle-like turn determine...
Recently, near‐infrared (NIR) absorbing conjugated polymeric nanoparticles have received significant attention in photothermal therapy of cancer. Herein, polypyrrole (PPy), a NIR‐absorbing conjugate polymer, is used to coat ultra‐small iron oxide (IONPs), obtaining multifunctional IONP@PPy nanocomposite which further modified by the biocompatible polyethylene glycol (PEG) through layer‐by‐layer method acquire high stability physiological solutions. Utilizing optical and magnetic properties...