A5071726444- Microfluidic and Capillary Electrophoresis Applications
- Semiconductor Lasers and Optical Devices
- Nanoparticle-Based Drug Delivery
- Photonic and Optical Devices
- Microfluidic and Bio-sensing Technologies
- Semiconductor Quantum Structures and Devices
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Graphene and Nanomaterials Applications
- Nanotechnology research and applications
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Advanced Biosensing Techniques and Applications
- Electrowetting and Microfluidic Technologies
- Nanofabrication and Lithography Techniques
- Quantum Dots Synthesis And Properties
- Molecular Communication and Nanonetworks
- Molecular Junctions and Nanostructures
- Nanoparticles: synthesis and applications
- Biosensors and Analytical Detection
- Photonic Crystals and Applications
- Semiconductor materials and devices
- Biomedical and Engineering Education
- Advanced Semiconductor Detectors and Materials
National Cancer Institute
2015-2024
National Institutes of Health
2011-2024
Brigham and Women's Hospital
2013
Brown Foundation
2013
UNC Lineberger Comprehensive Cancer Center
2013
The University of Texas Health Science Center at Houston
2013
Shaare Zedek Medical Center
2013
AstraZeneca (United Kingdom)
2013
Massachusetts General Hospital
2013
Harvard University
2013
Enhanced permeability of the tumor vasculature allows macromolecules to enter interstitial space, whereas suppressed lymphatic filtration them stay there. This phenomenon, enhanced and retention (EPR), has been basis nanotechnology platforms deliver drugs tumors. However, progress in developing effective using this approach hampered by heterogeneity EPR effect different tumors limited experimental data from patients on effectiveness mechanism as related drug accumulation. report summarizes...
A fully integrated biochip device that consists of microfluidic mixers, valves, pumps, channels, chambers, heaters, and DNA microarray sensors was developed to perform analysis complex biological sample solutions. Sample preparation (including magnetic bead-based cell capture, preconcentration purification, lysis), polymerase chain reaction, hybridization, electrochemical detection were performed in this automated miniature device. Cavitation microstreaming implemented enhance target capture...
A mixing technique based on the principle of bubble-induced acoustic microstreaming was developed. The mixer consists a piezoelectric disk that is attached to reaction chamber, which designed in such way set air bubbles with desirable size trapped solution. Fluidic experiments showed resting solid surface and into vibration by sound field generated steady circulatory flows, resulting global convection flows thus rapid mixing. time fully mix 22 microL chamber significantly reduced from hours...
Conventional DNA microarray hybridization relies on diffusion of target to surface-bound probes, and thus is a rate-limited process. In this paper, micromixing technique based cavitation microstreaming principle that was developed accelerate process explained. Fluidic experiments showed air bubbles resting solid surface set into vibration by sound field generated steady circulatory flows, resulting in global convection flows and, thus, rapid mixing. The time fully mix dyed solutions 50-μL...
The microchip capillary electrophoresis (CE) devices were fabricated in polycarbonate (PC) plastic material by compression molding. molded enclosed utilizing thermal bonding to another PC wafer. These bonds do not yield up an applied force equivalent 150 psi. Aqueous fluid transport inside the CE was enhanced UV irradiation treatment of hydrophobic surfaces prior bonding. In comparison glass microchannels, electroosmotic flow (EOF) native channels is low and independent buffer pH at 7 9....
Research activity in medical and cancer nanotechnology has grown dramatically over the past 15 years. The field become a cradle of multidisciplinary investigations bringing together physicists, chemists, engineers working with clinicians biologists to address paramount problems care treatment. Some have argued that explosion number research papers not been followed by sufficient clinical nanomedicine. However, three new nanodrugs now approved U.S. Food Drug Administration (FDA) years,...
PCR amplification, DNA hybridization, and a hybridization wash have been integrated in disposable monolithic device, containing all of the necessary fluidic channels reservoirs. These devices were fabricated polycarbonate plastic material by CO2 laser machining assembled using combination thermal bonding adhesive tape bonding. Pluronics polymer phase change valves implemented to fulfill valving requirements. is compatible, 30% provide enough holding pressure ensure successful amplification....
Small volume operation and rapid thermal cycling have been subjects of numerous reports in micro reactor chip development. Sensitivity aspects the PCR not studied detail, however, despite fact that detection rare targets or trace genomic material from clinical and/or environmental samples has a great challenge for microfluidic devices. In this study, serpentine shaped thin (0.75 mm) polycarbonate plastic was designed, constructed, tested only its efficiency, but also sensitivity specificity,...
The effect of strain on Auger recombination has been studied using the differential carrier lifetime technique in both lattice matched InGaAs-InP and compressively strained quaternary quantum wells. It is found that reduced devices. transparency density gain devices have obtained by relative intensity noise measurement. A reduction observed device. However, no increase seen. temperature sensitivity threshold current fully studied. Physical parameters contributing to separately measured, it...
Nanotechnology will have great impact on how cancer is diagnosed and treated in the future. New technologies to detect image cancerous changes materials that enable new methods of treatment radically alter patient outcomes. The National Cancer Institute (NCI) Alliance for sponsors research prevention, diagnosis, therapy promotes translation basic science discoveries into clinical practice. Fourth Annual NCI Principal Investigator Meeting was held Manhattan Beach, California October 20−22,...