A5003655999- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Angiogenesis and VEGF in Cancer
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Parathyroid Disorders and Treatments
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Thyroid Cancer Diagnosis and Treatment
- Pancreatic function and diabetes
- Virus-based gene therapy research
- Endoplasmic Reticulum Stress and Disease
- Intraperitoneal and Appendiceal Malignancies
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Thyroid and Parathyroid Surgery
- CAR-T cell therapy research
- Renal cell carcinoma treatment
- Adrenal and Paraganglionic Tumors
- Gene expression and cancer classification
- Genomics and Chromatin Dynamics
- Surgical Sutures and Adhesives
- Genetics and Neurodevelopmental Disorders
Rutgers, The State University of New Jersey
2015-2025
Rutgers Cancer Institute of New Jersey
2009-2024
Johnson University
2019-2023
National Cancer Institute
2006-2023
Montefiore Medical Center
2010-2023
Albert Einstein College of Medicine
2011-2023
Center for Cancer Research
2003-2023
Angiogenesis Foundation
2008-2023
American College of Surgeons
2022
Robert Wood Johnson University Hospital
2021
Abstract Purpose: A novel nanomedicine, CYT-6091, constructed by simultaneously binding recombinant human tumor necrosis factor alpha (rhTNF) and thiolyated polyethylene glycol to the surface of 27-nm colloidal gold particles, was tested in a phase I dose escalation clinical trial advanced stage cancer patients. Experimental Design: whose dosing based on amount rhTNF injected intravenously, 1 cycle treatment consisted 2 treatments administered 14 days apart. Results: Doses from 50 μg/m2 600...
Abstract Purpose: To determine if pulsed-high intensity focused ultrasound (HIFU) could effectively serve as a source of hyperthermia with thermosensitive liposomes to enhance delivery and efficacy doxorubicin in tumors. Experimental Design: Comparisons vitro vivo were carried out between non–thermosensitive (NTSL) low temperature–sensitive (LTSL). Liposomes incubated over range temperatures durations, the amount released was measured. For experiments, free injected i.v. mice followed by...
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant cancer syndrome, characterized primarily by multiple tumors in the parathyroid glands, pancreas, and anterior pituitary. Other tumors, including gastrinoma, carcinoid, adrenal cortical angiofibroma, collagenoma, lipoma, also occur some patients. Individuals with MEN1 almost always have loss-of-function mutations gene on chromosome 11, arising these patients usually show somatic loss of remaining wild-type allele. To examine...
Abstract This manuscript is the result of North American Neuroendocrine Tumor Society consensus conference on surgical management pancreatic neuroendocrine tumors from July 19 to 20, 2018. The group reviewed a series questions specific interest surgeons taking care patients with tumors, and for each, available literature was reviewed. What follows are these reviews each question followed by recommendations panel.
Malignant mesothelioma (MM) arising in the peritoneal cavity is a rare neoplasm characterized by progression and for which there are limited therapeutic options. We evaluated progression-free overall survival (PFS OS, respectively) patients with MM after surgical resection regional chemotherapy.Forty-nine (28 males, 21 females; median age, 47 years; range, 16 to 76 years) underwent laparotomy, tumor resection, continuous hyperthermic perfusion cisplatin (median dose 250 mg/m2), single...
While altered expression of microRNAs (miRs) in tumors has been well documented, it remains unclear how the miR transcriptome intersects neoplastic progression. By profiling we identified signatures associated with steps tumorigenesis and acquisition hallmark capabilities a prototypical mouse model cancer. Metastases rare subset primary shared distinct signature, implicating discrete lineage for metastatic tumors. The miR-200 family is strongly down-regulated metastases met-like tumors,...
Insulinoma causes fasting hypoglycemia due to inappropriate insulin secretion. Its diagnosis is based on demonstrating Whipple's triad during a supervised 72-h fast. For 75 yr, the fast has been cornerstone for diagnosis; however, it never critically assessed using newer assays insulin, C peptide, and proinsulin. Thus, aim of current study assess need full insulinoma. Patients with suspected documented glucose concentrations below 45 mg/dL were admitted NIH. Data obtained patients...
Drug resistance in breast cancer is a major obstacle to successful chemotherapy. In this study we used cDNA microarray technology examine gene expression profiles obtained from fine needle aspiration (FNA) of primary tumors before and after systemic Our goal was determine the feasibility obtaining representative array limited amounts tissue identify those that correlate with treatment response. Repeat presurgical FNA samples were taken six patients who undergo surgical treatment....
Recently, there has been tremendous interest in developing techniques such as MRI, micro-CT, micro-PET, and SPECT to image function processes small animals. These technologies offer deep tissue penetration high spatial resolution, but compared with noninvasive animal optical imaging, these are very costly time consuming implement. Optical imaging is cost-effective, rapid, easy use, can be readily applied studying disease biology vivo. In vivo the result of a coalescence from chemistry,...
Endothelial-monocyte activating polypeptide II (EMAP II) was initially identified in the supernatant of murine methylcholanthrene A-induced fibrosarcomas (Meth A) by its capacity to activate host effector cells (Kao, J., Ryan, Brett, Chen, Shen, H., Fan, Y-G., Godman, G., Familletti, P., Wang, F., Pan, Y-C., Stern, D., and Clauss, M. (1992) J. Biol. Chem. 267, 20239-20247). Based on NH2-terminal protein sequence, a full-length cDNA has been cloned which indicates that precursor EMAP is...
Selective intraarterial calcium injection of the major pancreatic arteries with hepatic venous sampling [calcium arterial stimulation (CaStim)] has been used as a localizing tool for insulinomas at National Institutes Health (NIH) since 1989. The accuracy this technique was reported all cases until 1996.The aim study to assess and track record CaStim over time in context evolving technology review issues related result interpretation procedure complications. only invasive preoperative...
Partial-volume errors (PVEs) in PET can cause incorrect estimation of radiopharmaceutical uptake small tumors. An iterative postreconstruction method was evaluated that corrects for PVEs without a priori knowledge tumor size or background.Volumes interest (VOIs) were drawn on uncorrected images. PVE-corrected images produced using an 3-dimensional deconvolution algorithm and local point spread function. The VOIs projected the corrected image to estimate mean activity concentration. These...
Formalin-fixed, paraffin-embedded (FFPE) tissue is the most common specimen available for molecular assays on after diagnostic histopathological examination. RNA from FFPE suffers strand breakage and cross-linking. Despite excellent extraction methods, quality material remains variable. To address factors within tissues, we studied quality, isolating individual elements of fixation processing including length in formalin type buffer incorporated fixative. We examined impact cycle as well....
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease. Tumors are poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor microenvironment. Here, we present microbial-based immunotherapeutic treatment for selective delivery of an tetanus toxoid protein (TT 856-1313 ) into PDAC cells by attenuated Listeria monocytogenes . This reactivated preexisting TT-specific memory to kill infected mice. Treatment KrasG12D,p53R172H, Pdx1-Cre (KPC) mice with -TT...