W. Marston Linehan
A5107963543- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Adrenal and Paraganglionic Tumors
- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- Bladder and Urothelial Cancer Treatments
- Pituitary Gland Disorders and Treatments
- Prostate Cancer Treatment and Research
- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Tuberous Sclerosis Complex Research
- Pancreatic and Hepatic Oncology Research
- Hormonal Regulation and Hypertension
- Molecular Biology Techniques and Applications
- Pediatric Urology and Nephrology Studies
- Medical Imaging and Pathology Studies
- Genetic factors in colorectal cancer
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Urologic and reproductive health conditions
- Neuroendocrine Tumor Research Advances
- Renal and Vascular Pathologies
- Cancer Immunotherapy and Biomarkers
National Cancer Institute
2016-2025
National Institutes of Health
2016-2025
Center for Cancer Research
2016-2025
National Institutes of Health Clinical Center
1994-2020
Collegio Carlo Alberto
2020
National Heart Lung and Blood Institute
1985-2019
Accreditation Council for Graduate Medical Education
2019
Memorial Sloan Kettering Cancer Center
2011-2019
Hokkaido University
2019
National Institute on Aging
2018
We studied the effects of adoptive immunotherapy with lymphokine-activated killer (LAK) cells plus interleukin-2 or therapy high-dose alone in 157 patients metastatic cancer for whom standard had proved ineffective no effective treatment was available. One hundred eight were treated 127 courses LAK interleukin-2, and 49 53 alone. Of 106 evaluable receiving 8 complete responses, 15 partial 10 minor responses. The median duration response months among those responses 6 responses; patient...
Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for majority spontaneous clear-cell renal carcinomas. We now show that hypermethylation a normally unmethylated CpG island in 5' region provides another potentially important mechanism VHL significant portion these cancers. This was found 5 26 (19%) tumors examined. Four had lost one copy while retained two heavily methylated alleles. with no detectable mutations, whereas missense mutation...
Targeted magnetic resonance (MR)/ultrasound fusion prostate biopsy has been shown to detect cancer. The implications of targeted alone vs standard extended-sextant or the 2 modalities combined are not well understood.To assess and approaches for diagnosis intermediate- high-risk cancer.Prospective cohort study 1003 men undergoing both concurrently from 2007 through 2014 at National Cancer Institute in United States. Patients were referred elevated level prostate-specific antigen (PSA)...
Papillary renal-cell carcinoma, which accounts for 15 to 20% of carcinomas, is a heterogeneous disease that consists various types renal cancer, including tumors with indolent, multifocal presentation and solitary an aggressive, highly lethal phenotype. Little known about the genetic basis sporadic papillary no effective forms therapy advanced exist.We performed comprehensive molecular characterization 161 primary using whole-exome sequencing, copy-number analysis, messenger RNA microRNA...
ContextDiagnosis of pheochromocytoma depends on biochemical evidence catecholamine production by the tumor. However, best test to establish diagnosis has not been determined.ObjectiveTo determine or combination tests that provides method for pheochromocytoma.Design, Setting, and ParticipantsMulticenter cohort study patients tested at 4 referral centers between 1994 2001. The analysis included 214 in whom was confirmed 644 who were determined have tumor.Main Outcome MeasuresTest sensitivity...
Since allogeneic stem-cell transplantation can induce curative graft-versus-leukemia reactions in patients with hematologic cancers, we sought to analogous graft-versus-tumor effects metastatic renal-cell carcinoma by means of nonmyeloablative peripheral-blood transplantation.
We have administered 1039 courses of high-dose interleukin-2 (IL-2) to 652 cancer patients. Five hundred ninety-six patients had metastatic that either failed standard effective therapies or disease for which no therapy existed, and 56 were treated in the absence evaluable adjuvant setting. IL-2 was alone (155 patients) conjunction with activated immune cells such as lymphokine killer (LAK) (214 tumor infiltrating lymphocytes (TIL) (66 patients), other cytokines alpha interferon (a-IFN)(128...
Pathologic states within the prostate may be reflected by changes in serum proteomic patterns. To test this hypothesis, we analyzed mass spectra with a bioinformatics tool to reveal most fit pattern that discriminated training set of sera men histopathologic diagnosis cancer (serum prostate-specific antigen [PSA] > or =4 ng/mL) from those without PSA level <1 ng/mL). Mass blinded (N = 266) derived were matched against discriminating revealed set. A predicted benign disease was rendered based...
The use of 12-core systematic prostate biopsy is associated with diagnostic inaccuracy that contributes to both overdiagnosis and underdiagnosis cancer. Biopsies performed magnetic resonance imaging (MRI) targeting may reduce the misclassification cancer in men MRI-visible lesions.
Journal Article Prospective Randomized Trial of High-Dose Interleukin-2 Alone or in Conjunction With Lymphokine-Activated Killer Cells for the Treatment Patients Advanced Cancer Get access Steven A. Rosenberg, Rosenberg Surgery Branch, Division Treatment, National InstituteBethesda, Md Correspondence to: M.D., Ph.D., Bldg. 10 Rm. 2B42, Institutes Health, Bethesda, MD 20892. Search other works by this author on: Oxford Academic PubMed Google Scholar Michael T. Lotze, Lotze James C. Yang, Yang...
Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear RCC, 274 papillary 81 chromophobe RCC. Comprehensive genomic phenotypic analysis of subtypes reveals distinctive features each subtype that provide foundation for development subtype-specific management strategies patients...
Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant genodermatosis characterized by the development of small dome-shaped papules on face, neck, and upper trunk (fibrofolliculomas). In addition to these benign hair follicle tumors, BHD confers increased risk renal neoplasia spontaneous pneumothorax. To date, there has been no systematic pathologic analysis tumors associated with this syndrome. We reviewed 130 solid resected from 30 patients in 19 different families. Preoperative computed...
To elucidate the deregulated functional modules that drive clear cell renal carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration proteogenomic measurements uniquely protein dysregulation cellular mechanisms impacted by alterations, including...
von Hippel-Lindau disease (VHL) is an inherited neoplastic characterized by a predisposition to develop retinal angiomas, central nervous system hemangioblastomas, renal cell carcinomas, pancreatic cysts, and pheochromocytomas. The VHL gene was recently isolated positional cloning. cDNA encodes 852 nucleotides in 3 exons. unrelated any known families. We identified germline mutations 85/114 (75%) of Clinical heterogeneity well-known feature VHL. families were classified into 2 types based on...
Abstract Purpose: To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation the von Hippel-Lindau (VHL) gene in cancer genome, unique to clear cell renal (ccRCC). Identify relationships between prevalence VHL alterations alteration subtypes with patient tumor characteristics. Experimental Design: As part large kidney case-control study conducted Central Europe, we analyzed mutations methylation 205 well-characterized, histologically confirmed biopsies...
Germline mutation analysis was performed in 469 VHL families from North America, Europe, and Japan. mutations were identified 300/469 (63%) of the tested; 137 distinct intragenic germline detected. Most (124/137) occurred 1-2 families; a few occured four or more families. The common were: delPhe76, Asn78Ser, Arg161Stop, Arg167Gln, Arg167Trp, Leu178Pro. In this large series, it possible to compare effects identical different populations. produced similar cancer phenotypes Caucasian Japanese...
The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL syndrome and is an early genetic event associated with sporadic renal cell carcinoma CNS hemangioblastomas. protein (pVHL) has been shown form a stable complex elongin B C, two factors that stabilize activate transcription elongation factor A. Here, Hs-CUL-2, member recently identified multigene family, cullins, specifically associate trimeric pVHL-elongin B-C (VBC) in vitro vivo . Nearly 70%...