A5082080836- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Cancer Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Medical Imaging Techniques and Applications
- Immunotherapy and Immune Responses
- Advanced MRI Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- AI in cancer detection
- Medical Image Segmentation Techniques
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Lanthanide and Transition Metal Complexes
- Nanoparticle-Based Drug Delivery
- Medical Imaging and Pathology Studies
National Cancer Institute
2016-2025
Center for Cancer Research
2016-2025
National Institutes of Health
2016-2025
National Cancer Institute
1995-2024
Singapore General Hospital
2018-2024
Nvidia (United States)
2024
ABT Molecular Imaging (United States)
2014-2023
Cancer Institute (WIA)
2008-2023
National Heart Lung and Blood Institute
1991-2021
National Institutes of Health Clinical Center
2005-2021
The aim was to develop clinical guidelines for multi-parametric MRI of the prostate by a group experts from European Society Urogenital Radiology (ESUR), based on literature evidence and consensus expert opinion. True evidence-based could not be formulated, but compromise, reflected "minimal" "optimal" requirements has been made. scope these ESUR is promulgate high quality in acquisition evaluation with correct indications cancer across whole Europe eventually outside Europe. optimal...
On May 3, 2008, a National Cancer Institute (NCI)-sponsored open consensus conference was held in Toronto, Ontario, Canada, during the 2008 International Society for Magnetic Resonance Medicine Meeting. Approximately 100 experts and stakeholders summarized current understanding of diffusion-weighted magnetic resonance imaging (DW-MRI) reached on use DW-MRI as cancer biomarker. should be tested an biomarker context well-defined clinical trials, by adding to existing NCI-sponsored particularly...
Targeted magnetic resonance (MR)/ultrasound fusion prostate biopsy has been shown to detect cancer. The implications of targeted alone vs standard extended-sextant or the 2 modalities combined are not well understood.To assess and approaches for diagnosis intermediate- high-risk cancer.Prospective cohort study 1003 men undergoing both concurrently from 2007 through 2014 at National Cancer Institute in United States. Patients were referred elevated level prostate-specific antigen (PSA)...
Stimulating an immune response against cancer with the use of vaccines remains a challenge. We hypothesized that combining melanoma vaccine interleukin-2, activating agent, could improve outcomes. In previous phase 2 study, patients metastatic receiving high-dose interleukin-2 plus gp100:209-217(210M) peptide had higher rate than is expected among who are treated alone.We conducted randomized, 3 trial involving 185 at 21 centers. Eligibility criteria included stage IV or locally advanced III...
The use of 12-core systematic prostate biopsy is associated with diagnostic inaccuracy that contributes to both overdiagnosis and underdiagnosis cancer. Biopsies performed magnetic resonance imaging (MRI) targeting may reduce the misclassification cancer in men MRI-visible lesions.
Ascorbate (ascorbic acid, vitamin C), in pharmacologic concentrations easily achieved humans by i.v. administration, selectively kills some cancer cells but not normal cells. We proposed that ascorbate is a prodrug for preferential steady-state formation of radical (Asc(*-)) and H(2)O(2) the extracellular space compared with blood. Here we test this hypothesis vivo. Rats were administered parenteral (i.v. or i.p.) oral typical human doses ( approximately 0.25-0.5 mg per gram body weight)....
Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Artificial intelligence (AI) has the potential to aid in rapid evaluation scans differentiation findings from other entities. Here we show that series deep learning algorithms, trained diverse multinational cohort 1280 patients localize parietal pleura/lung parenchyma followed by classification pneumonia, can achieve up 90.8% accuracy, with 84% sensitivity and 93% specificity,...
Purpose Vascular endothelial growth factor (VEGF) is a potent molecule that mediates tumor angiogenesis primarily through VEGF receptor 2 (VEGFR2). Bevacizumab, recombinant humanized monoclonal antibody to VEGF, was administered previously untreated patients evaluate parameters of angiogenesis. Patients and Methods Twenty-one with inflammatory locally advanced breast cancer were treated bevacizumab for cycle 1 (15 mg/kg on day 1) followed by six cycles doxorubicin (50 mg/m ) docetaxel (75...