A5073641029- Birth, Development, and Health
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Renal cell carcinoma treatment
- Pregnancy and preeclampsia studies
- Insurance, Mortality, Demography, Risk Management
- Renal and Vascular Pathologies
- Genetic and Kidney Cyst Diseases
- Organ Donation and Transplantation
- Cervical Cancer and HPV Research
- Muscle and Compartmental Disorders
- Dialysis and Renal Disease Management
- Health, Environment, Cognitive Aging
- Sodium Intake and Health
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Systemic Lupus Erythematosus Research
- Diabetes and associated disorders
- Blood Pressure and Hypertension Studies
- Autopsy Techniques and Outcomes
- Systemic Sclerosis and Related Diseases
- Viral-associated cancers and disorders
- Genital Health and Disease
University of Sulaimani
2020-2025
Hawler Medical University
2020
University of Duhok
2011-2020
University of Mississippi Medical Center
2009-2019
Jackson Memorial Hospital
2009-2019
Kurdistan Regional Government
2015-2018
University of Mississippi
2003-2011
GTx (United States)
2008
Royal Brisbane and Women's Hospital
2007-2008
The University of Queensland
2003-2007
The cellular origins of glomerulosclerosis involve activation parietal epithelial cells (PECs) and progressive podocyte depletion. While mammalian target rapamycin-mediated (mTOR-mediated) hypertrophy is recognized as an important signaling pathway in the context glomerular disease, role a compensatory mechanism preventing PEC remains poorly understood. In this study, we show that mTOR activation-related genes were both upregulated intercorrelated biopsies from patients with focal segmental...
Abstract Background.—Shortened life expectancy due to pulmonary hypertension (PH) is seen in 5% 10% of patients with sickle cell disease. The principal factors suspected causing PH are thromboemboli (PE) and situ arterial thrombosis. Objective.—To investigate the possible role that PE or thrombosis play development Methods.—Autopsies 12 disease were correlated clinical data from medical records. Results.—Right ventricular hypertrophy was present 9 patients. Six right had thrombi large...
Congenital nephron number varies five-fold among normal humans, and individuals at the lower end of this range may have an increased lifetime risk for essential hypertension or renal insufficiency; however, mechanisms that determine are unknown. This study tested hypothesis common hypomorphic variants RET gene, which encodes a tyrosine kinase receptor critical branching morphogenesis, might account subtle hypoplasia in some newborns. A single-nucleotide polymorphism (rs1800860 G/A) was...
The goal of this study was to test the hypothesis that oxidative stress in Dahl salt-sensitive (SS) rats on a high-sodium intake contributes progression renal damage, decreases hemodynamics, and development hypertension. We specifically studied whether antioxidant therapy, using vitamins C E, could help prevent damage glomerular filtration rate (GFR) plasma flow reductions attenuate increases arterial pressure. Thirty-three 7- 8-week old SS/Rapp strain were placed either (8%) or low-sodium...
The goal of this study was to test the hypothesis that increases in oxidative stress Dahl S rats on a high-salt diet help stimulate renal nuclear factor-κB (NF-κB), proinflammatory cytokines, and chemokines, thus contributing hypertension, damage, dysfunction. We specifically studied whether antioxidant treatment high Na intake would decrease inflammation attenuate hypertensive adverse responses. Sixty-four 7- 8-wk-old or R/Rapp strain were maintained for 5 wk (8%) + vitamins C (1 g/l...
BACKGROUND. The objective of the current study was to test hypothesis that cytologic diagnosis cancer cells can be enhanced by technique hyperspectral imaging (HSI). METHODS. As a proof principle, HSI employed obtain hyperspectrum from normal human fibroblast, as well its telomerase-immortalized and SV40-transformed derivatives. Novel algorithms were developed differentiate among these cell models based on spectral spatial differences. Using same with modified algorithms, authors able...
African Americans have more severe hypertensive nephrosclerosis than white Americans, possibly at similar levels of blood pressure. Glomerular volume is increased in relative to whites, but it uncertain how this relates and whether contributes or compensates for glomerulosclerosis. Stereological disector/fractionator estimates glomerular number (Nglom) average (Vglom) were obtained on autopsy kidneys 171 131 whites. Eighty-eight 49 whites identified as hypertensive. Nephrosclerosis was...
It has been suggested that low nephron number contributes to glomerular hypertension and hyperperfusion injury in progressive chronic kidney disease (CKD). The incidence of CKD Japan is among the highest world, but reasons remain unclear. We estimated total (glomerular) (NglomTOTAL) as well numbers nonsclerosed (NglomNSG) globally sclerosed glomeruli (NglomGSG), mean volume (VglomNSG) Japanese normotensive, hypertensive, subjects investigated associations between these parameters filtration...
Podocyte depletion plays a major role in the development and progression of glomerulosclerosis. Many kidney diseases are more common older age often coexist with hypertension. We hypothesized that podocyte develops association is exacerbated by Kidneys from 19 adult Caucasian American males without overt renal disease were collected at autopsy Mississippi. Demographic data obtained medical records. Subjects categorized hypertension as potential independent additive contributors to depletion....
Enlarged glomerular size is a feature of focal segmental glomerulosclerosis, obesity-related glomerulopathy, diabetic nephropathy, and hypertension. The distribution volumes within different cortical zones volume alterations with age obesity may contribute to understanding the evolution these diseases. We analyzed distributions individual glomeruli in superficial, middle, juxtamedullary cortex normal human kidneys using disector/Cavalieri method. Volumes (V<sub>glom</sub>) 720 nonsclerotic...
The goal of this study was to test the hypothesis that renal infiltration immune cells in Dahl S rats on increased dietary sodium intake contributes progression damage, decreases hemodynamics, and development hypertension. We specifically studied whether anti-immune therapy, using mycophenolate mofetil (MMF), could help prevent increases NF-kappaB activation, monocytes/macrophages, glomerular filtration rate (GFR) plasma flow, arterial pressure. Seventy-four 7-to 8-wk-old S, Rapp strain were...
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