A5038850729- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Urologic and reproductive health conditions
- MRI in cancer diagnosis
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Cancer Genomics and Diagnostics
- Renal and Vascular Pathologies
- Adrenal and Paraganglionic Tumors
- Cancer, Lipids, and Metabolism
- AI in cancer detection
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Genetic and Kidney Cyst Diseases
- Radiopharmaceutical Chemistry and Applications
- Medical Image Segmentation Techniques
- Cancer Immunotherapy and Biomarkers
- Hormonal Regulation and Hypertension
Worcester Polytechnic Institute
2025
National Institutes of Health
2016-2025
National Cancer Institute
2016-2025
Center for Cancer Research
2015-2024
Singapore General Hospital
2018-2024
Nvidia (United States)
2024
Urological Society of Australia and New Zealand
2020-2023
Evidence (Italy)
2023
Michigan Department of Education
2023
American Urological Association
2023
Multiparametric magnetic resonance imaging (MRI), with or without targeted biopsy, is an alternative to standard transrectal ultrasonography-guided biopsy for prostate-cancer detection in men a raised prostate-specific antigen level who have not undergone biopsy. However, comparative evidence limited.In multicenter, randomized, noninferiority trial, we assigned clinical suspicion of prostate cancer had previously undergo MRI, Men the MRI-targeted group underwent (without cores) if MRI was...
Targeted magnetic resonance (MR)/ultrasound fusion prostate biopsy has been shown to detect cancer. The implications of targeted alone vs standard extended-sextant or the 2 modalities combined are not well understood.To assess and approaches for diagnosis intermediate- high-risk cancer.Prospective cohort study 1003 men undergoing both concurrently from 2007 through 2014 at National Cancer Institute in United States. Patients were referred elevated level prostate-specific antigen (PSA)...
The use of 12-core systematic prostate biopsy is associated with diagnostic inaccuracy that contributes to both overdiagnosis and underdiagnosis cancer. Biopsies performed magnetic resonance imaging (MRI) targeting may reduce the misclassification cancer in men MRI-visible lesions.
We determined the prostate cancer detection rate of multiparametric magnetic resonance imaging at 3T. Precise one-to-one histopathological correlation with was possible using based custom printed specimen molds after radical prostatectomy.This institutional review board approved prospective study included 45 patients (mean age 60.2 years, range 49 to 75) a mean specific antigen 6.37 ng/ml (range 2.3 23.7) who had biopsy proven Gleason score 6.7, 6 9). Before prostatectomy all underwent...
To determine utility of multiparametric imaging performed at 3 T for detection prostate cancer by using T2-weighted magnetic resonance (MR) imaging, MR spectroscopy, and dynamic contrast material-enhanced with whole-mount pathologic findings as reference standard.This prospectively designed, HIPAA-compliant, single-institution study was approved the local institutional review board. Seventy consecutive patients (mean age, 60.4 years; mean prostate-specific antigen level, 5.47 ng/mL [5.47...
No AccessJournal of UrologyAdult Urology1 Oct 2011Magnetic Resonance Imaging/Ultrasound Fusion Guided Prostate Biopsy Improves Cancer Detection Following Transrectal Ultrasound and Correlates With Multiparametric Magnetic Imaging Peter A. Pinto, Paul H. Chung, Ardeshir R. Rastinehad, Angelo Baccala, Jochen Kruecker, Compton J. Benjamin, Sheng Xu, Pingkun Yan, Samuel Kadoury, Celene Chua, Julia K. Locklin, Baris Turkbey, Joanna Shih, Stacey P. Gates, Carey Buckner, Gennady Bratslavsky, W....
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant familial syndrome characterized by the development of cutaneous uterine leiomyomas as well tumors. The mutation this condition has been identified in fumarate hydratase (FH, 1q42.3-q43) gene. histology cancers not described or illustrated because newness syndrome. We reviewed 40 tumors resected from 38 patients belonging to HLRCC families with proven germline mutation. Patients ranged age 17 75 years age....
Purpose To investigate whether apparent diffusion coefficients (ADCs) derived from diffusion-weighted (DW) magnetic resonance (MR) imaging at 3 T correlate with the clinical risk of prostate cancer in patients tumors that are visible on MR images, imaging/transrectal ultrasonography (US) fusion–guided biopsy as a reference. Materials and Methods Forty-eight consecutive (median age, 60 years; median serum prostate-specific antigen value, 6.3 ng/mL) who underwent DW during 3-T an endorectal...
To evaluate accuracy and interobserver variability with the use of Prostate Imaging Reporting Data System (PI-RADS) version 2.0 for detection prostate cancer at multiparametric magnetic resonance (MR) imaging in a biopsy-naïve patient population.This retrospective HIPAA-compliant study was approved by local ethics committee, written informed consent obtained from all patients their histopathologic data future research studies. In 101 elevated prostate-specific antigen levels who underwent MR...
Background Prostate MRI is used widely in clinical care for guiding tissue sampling, active surveillance, and staging. The Imaging Reporting Data System (PI-RADS) helps provide a standardized probabilistic approach identifying clinically significant prostate cancer. Despite widespread use, the variability performance of across practices remains unknown. Purpose To estimate positive predictive value (PPV) PI-RADS detection high-grade cancer imaging centers. Materials Methods This...
Targeted prostate biopsy is challenging because no currently established imaging modality both accurate for cancer diagnosis and cost-effective real-time procedure guidance. A system that fuses transrectal ultrasound images with previously acquired endorectal coil MRI guidance presented here. The uses electromagnetic tracking intraoperative image registration to superimpose the data on image. Prostate motion tracked compensated without need fiducial markers. accuracy of in phantom studies...
Patients with negative transrectal ultrasound biopsies and a persistent clinical suspicion are at risk for occult but significant prostate cancer. The ability of multiparametric magnetic resonance imaging/ultrasound fusion biopsy to detect these lesions may make it an effective tool in this challenging scenario.
Focal therapy as a treatment option for localized prostate cancer (PCa) is an increasingly popular and rapidly evolving field.
Germline testing (GT) is a central feature of prostate cancer (PCA) treatment, management, and hereditary assessment. Critical needs include optimized multigene strategies that incorporate evolving genetic data, consistency in GT indications alternate evaluation models address the rising demand for services. A multidisciplinary consensus conference included experts, stakeholders, national organization leaders was convened response to current practice challenges develop implementation...
Purpose To characterize clinically important prostate cancers missed at multiparametric (MP) magnetic resonance (MR) imaging. Materials and Methods The local institutional review board approved this HIPAA-compliant retrospective single-center study, which included 100 consecutive patients who had undergone MP MR imaging subsequent radical prostatectomy. A genitourinary pathologist blinded to findings outlined on whole-mount pathology slices. Two readers correlated mapped lesions with reports...
No AccessJournal of UrologyAdult Urology1 Dec 2012Succinate Dehydrogenase Kidney Cancer: An Aggressive Example the Warburg Effect in Cancer Christopher J. Ricketts, Brian Shuch, Cathy D. Vocke, Adam R. Metwalli, Gennady Bratslavsky, Lindsay Middelton, Youfeng Yang, Ming-Hui Wei, Stephen E. Pautler, James Peterson, Catherine A. Stolle, Berton Zbar, Maria Merino, Laura S. Schmidt, Peter Pinto, Ramaprasad Srinivasan, Karel Pacak, and W. Marston Linehan RickettsChristopher Ricketts Urologic...
BACKGROUND Active surveillance (AS) is an attempt to avoid overtreatment of clinically insignificant prostate cancer (PCa); however, patient selection remains controversial. Multiparametric magnetic resonance imaging (MP‐MRI) may help better select AS candidates. METHODS We reviewed a cohort men who underwent MP‐MRI with MRI/Ultrasound fusion–guided biopsy and selected potential patients at entry using Johns Hopkins criteria. findings were assessed, including number lesions, dominant lesion...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked cancer. The relevance microRNAs in development, progression and prognosis prostate cancer is not fully understood. It also possible these specific may assist recognition aggressive tumors development new molecular targets. Our study investigated importance several cases from 37 patients were manually microdissected obtain pure populations tumor cells, normal epithelium adjacent...
We update the prior standard operating procedure for magnetic resonance imaging of prostate, and summarize available data about technique clinical use diagnosis management prostate cancer. This includes practical recommendations on screening, diagnosis, staging, treatment surveillance
To determine whether multiparametric magnetic resonance (MR) imaging can help identify patients with prostate cancer who would most appropriately be candidates for active surveillance (AS) according to current guidelines and compare the results those of conventional clinical assessment scoring systems, including D'Amico, Epstein, Cancer Prostate Risk Assessment (CAPRA) on basis findings at prostatectomy.This institutional review board-approved HIPAA-compliant retrospectively designed study...