A5055870934- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Cancer Treatment and Pharmacology
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Antioxidant Activity and Oxidative Stress
- Chemical Reactions and Isotopes
- Selenium in Biological Systems
- Urinary and Genital Oncology Studies
- Multiple Myeloma Research and Treatments
- Urologic and reproductive health conditions
- Chemical Synthesis and Analysis
- Statistical Methods in Clinical Trials
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Synthesis and Biological Evaluation
- Health Systems, Economic Evaluations, Quality of Life
- Radiopharmaceutical Chemistry and Applications
- Tea Polyphenols and Effects
- Lipoproteins and Cardiovascular Health
- Inflammatory mediators and NSAID effects
National Institutes of Health
2015-2024
National Cancer Institute
2015-2024
Center for Cancer Research
2007-2023
Cancer Institute (WIA)
2020-2023
University of Baltimore
1988-2020
Cardinal Glennon Children’s Medical Center
2020
Cornell University
2003-2019
The University of Texas MD Anderson Cancer Center
2002-2019
Christus Santa Rosa Health System
2019
Dana-Farber Cancer Institute
2011-2019
The optimal upper limit of the normal range for prostate-specific antigen (PSA) is unknown. We investigated prevalence prostate cancer among men in Prostate Cancer Prevention Trial who had a PSA level 4.0 ng per milliliter or less.Of 18,882 enrolled prevention trial, 9459 were randomly assigned to receive placebo and an annual measurement digital rectal examination. Among these men, 2950 never more than abnormal examination, final determination, underwent biopsy after being study seven...
<h3>Context</h3>Secondary analyses of 2 randomized controlled trials and supportive epidemiologic preclinical data indicated the potential selenium vitamin E for preventing prostate cancer.<h3>Objective</h3>To determine whether selenium, E, or both could prevent cancer other diseases with little no toxicity in relatively healthy men.<h3>Design, Setting, Participants</h3>A randomized, placebo-controlled trial (Selenium Vitamin Cancer Prevention Trial [SELECT]) 35 533 men from 427...
<h3>Context</h3>The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk prostate cancer with either selenium or vitamin supplements but a statistically nonsignificant increase E. Longer follow-up more events provide further insight into relationship cancer.<h3>Objective</h3>To determine long-term effect on relatively healthy men.<h3>Design, Setting, Participants</h3>A total 35 533 men from 427 study sites United States, Canada, Puerto Rico...
Targeted magnetic resonance (MR)/ultrasound fusion prostate biopsy has been shown to detect cancer. The implications of targeted alone vs standard extended-sextant or the 2 modalities combined are not well understood.To assess and approaches for diagnosis intermediate- high-risk cancer.Prospective cohort study 1003 men undergoing both concurrently from 2007 through 2014 at National Cancer Institute in United States. Patients were referred elevated level prostate-specific antigen (PSA)...
Background: Prostate-specific antigen (PSA) testing is the primary method used to diagnose prostate cancer in United States. Methods integrate other risk factors associated with into individualized prediction are needed. We biopsy data from men who participated Prostate Cancer Prevention Trial (PCPT) develop a predictive model of cancer. Methods: included 5519 placebo group PCPT underwent biopsy, had at least one PSA measurement and digital rectal examination (DRE) performed during year...
The use of 12-core systematic prostate biopsy is associated with diagnostic inaccuracy that contributes to both overdiagnosis and underdiagnosis cancer. Biopsies performed magnetic resonance imaging (MRI) targeting may reduce the misclassification cancer in men MRI-visible lesions.
Three fourths of US men older than 50 years have been screened with prostate-specific antigen (PSA) for prostate cancer.To estimate the receiver operating characteristic (ROC) curve PSA.Calculation PSA ROC curves in placebo group Prostate Cancer Prevention Trial, a randomized, prospective study conducted from 1993 to 2003 at 221 centers. Participants were 18 882 healthy aged 55 or without cancer and levels less equal 3.0 ng/mL normal digital rectal examination results, followed up 7 annual...
Prostate cancer continues to be a major health threat, especially among African American men. The Selenium and Vitamin E Cancer Prevention Trial (SELECT), which opened on July 25, 2001, was planned study possible agents for the prevention of prostate in population 32,400 men United States, including Puerto Rico, Canada. SELECT is phase III randomized, placebo-controlled trial selenium (200 microg/day from L-selenomethionine) and/or vitamin (400 IU/day all rac alpha-tocopheryl acetate)...
Both docetaxel and thalidomide have demonstrated activity in androgen-independent prostate cancer (AIPC). We compared the efficacy of to plus patients with AIPC.Seventy-five chemotherapy-naïve metastatic AIPC were randomly assigned receive either 30 mg/m(2) intravenously every week for 3 consecutive weeks, followed by a 1-week rest period (n = 25); or at same dose schedule, 200 mg orally each day 50). Prostate-specific antigen (PSA) consensus criteria radiographic scans used determine...
In the Prostate Cancer Prevention Trial (PCPT), men receiving finasteride had a 24.8% lower risk of prostate cancer than placebo but higher high-grade cancer. We examined impact on sensitivity and area under receiver operating characteristic curve (AUC) prostate-specific antigen (PSA) for detecting cancer.We studied in groups PCPT who biopsy concurrent PSA tests during 7-year study. compared AUC detection all cancer, Gleason grade 7 or 8 All statistical were two-sided.Of 5112 group, was...
In the Prostate Cancer Prevention Trial (PCPT), finasteride significantly reduced risk of prostate cancer but was associated with an increased high-grade disease. With up to 18 years follow-up, we analyzed rates survival among all study participants and those cancer.We collected data on incidence PCPT for additional year after our first report published in 2003 searched Social Security Death Index assess status through October 31, 2011.Among 18,880 eligible men who underwent randomization,...
The Selenium and Vitamin E Cancer Prevention Trial found no effect of selenium supplementation on prostate cancer (PCa) risk but a 17% increased from vitamin supplementation. This case–cohort study investigates effects conditional upon baseline status. There were 1739 total 489 high-grade (Gleason 7–10) PCa cases 3117 men in the randomly selected cohort. Proportional hazards models estimated hazard ratios (HRs) 95% confidence intervals (CIs) for within quintiles toenail selenium. Cox...
BACKGROUND Active surveillance (AS) is an attempt to avoid overtreatment of clinically insignificant prostate cancer (PCa); however, patient selection remains controversial. Multiparametric magnetic resonance imaging (MP‐MRI) may help better select AS candidates. METHODS We reviewed a cohort men who underwent MP‐MRI with MRI/Ultrasound fusion–guided biopsy and selected potential patients at entry using Johns Hopkins criteria. findings were assessed, including number lesions, dominant lesion...
Chronic inflammation is hypothesized to influence prostate cancer development, although a definitive link has not been established.
BackgroundThe Prostate Cancer Prevention Trial (PCPT) reported a decreased incidence of prostate cancer overall but an increase in the high-grade with finasteride compared placebo. We assessed whether increased associated PCPT was due to finasteride's potential effects on tumor morphology or size.
Abstract Background: Several prospective studies suggest that use of cholesterol-lowering statin drugs is inversely associated with advanced stage and possibly high-grade prostate cancer. One study reported men low cholesterol had a lower risk Given these findings, we investigated the association between serum cancer in Prostate Cancer Prevention Trial. Methods: We conducted cohort 5,586 ages ≥55 years who were randomized to placebo arm Trial 1993 1996. Serum was measured enzymatically at...
Multiparametric magnetic resonance imaging (MRI) in conjunction with MRI-transrectal ultrasound (TRUS) fusion-guided biopsies have improved the detection of prostate cancer. It is unclear whether MRI itself adds additional value to multivariable prediction models based on clinical parameters.To determine an MRI-based model can reduce unnecessary patients suspected cancer.Patients underwent MRI, MRI-TRUS biopsy, and 12-core systematic biopsy 1 session. The development cohort used derive...