A5024041740- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- GDF15 and Related Biomarkers
- Cancer Risks and Factors
- Hormonal and reproductive studies
- Nutritional Studies and Diet
- Apelin-related biomedical research
- Lipoproteins and Cardiovascular Health
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Nuclear Receptors and Signaling
- Urinary Bladder and Prostate Research
- Inflammatory Biomarkers in Disease Prognosis
- Telomeres, Telomerase, and Senescence
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Cardiovascular Health and Risk Factors
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Estrogen and related hormone effects
- Global Cancer Incidence and Screening
Johns Hopkins University
2016-2025
Sidney Kimmel Comprehensive Cancer Center
2016-2025
Johns Hopkins Medicine
2015-2024
University of Baltimore
2011-2024
Dartmouth College
2023
Bloomberg (United States)
2007-2023
Augusta University
2005-2023
Johns Hopkins Hospital
2005-2022
Harvard University
2000-2021
Imperial College London
2021
There has been a marked increase in testosterone prescriptions the past decade resulting growing need to give practicing clinicians proper guidance on evaluation and management of deficient patient.A systematic review utilized research from Mayo Clinic Evidence Based Practice Center additional supplementation by authors. Evidence-based statements were based body evidence strength Grade A, B, or C designated as Strong, Moderate, Conditional Recommendations with presented form Clinical...
Colonic mucosal bft detection was significantly higher in tumor-bearing patients than colonoscopy control and universal late-stage colorectal cancer (CRC). bft-2 the most frequent isotype identified, multiple isotypes were more often present CRC patients.
Abstract Risk factors for prostate cancer could differ various sub‐groups, such as “aggressive” and “non‐aggressive” cancers or by grade stage. Determinants of mortality from those incidence. Using data the Health Professionals Follow‐Up Study, we re‐examined 10 (cigarette smoking history, physical activity, BMI, family history cancer, race, height, total energy consumption, intakes calcium, tomato sauce α‐linolenic acid) using multivariable Cox regression in relation to multiple...
Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank GWA consortia, we found that a one standard deviation increment average acceleration was (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) (OR: 0.66, CI: 0.48 0.90, 0.01)....
Statins are commonly used cholesterol-lowering drugs that have proapoptotic and antimetastatic activities could affect cancer risk or progression. Results from previous epidemiologic studies of the association between statin use been inconsistent. We investigated with total advanced prostate cancer, latter being most important endpoint to prevent.We analyzed data an ongoing prospective cohort study 34,989 US male health professionals who were free in 1990 followed 2002. Participants reported...
Abstract Studies on the relationship between obesity and prostate cancer incidence are inconsistent. In part, this inconsistency may be due to a differential effect of low-grade high-grade or confounding association with risk by diabetes. We investigated associations diabetes risk. Data were from 10,258 participants (1,936 cancers) in Prostate Cancer Prevention Trial who all had presence absence determined biopsy. Multiple logistic regression was used model total cancer, polytomous cancer....
Low levels of androgens in men may play a role the development diabetes; however, few studies have examined association between androgen concentration and diabetes general population. The objective this study is to test hypothesis that low normal total, free, bioavailable testosterone are associated with prevalent men.The sample included 1,413 adult aged > or =20 years who participated morning session first phase Third National Health Nutrition Examination Survey, cross-sectional survey...
Benign prostatic hyperplasia poses a significant public health problem, but its etiology remains unclear. Obesity and associated abnormalities in glucose homeostasis may play role benign development by influencing prostate growth.
Thyroid cancer incidence has risen dramatically in the United States since early 1980s. Although prevalence of obesity doubled during this time period, relationship between and thyroid is uncertain.We examined association body mass index (BMI) risk a pooled analysis five prospective U.S. studies, including 413,979 women 434,953 men. Proportional hazards models with attained age as metric were adjusted for education, race, marital status, smoking, alcohol intake, (where appropriate) cohort...
Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin (25(OH)D) concentrations that minimize risk are unknown. Current Institute of Medicine (IOM) guidance based solely on bone health.
Chronic inflammation is hypothesized to influence prostate cancer development, although a definitive link has not been established.
Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due bias. In order examine altered genetically predicted concentration of circulating cytokines associated with development, we performed a two-sample Mendelian randomisation (MR) analysis.
Background: Accumulating evidence suggests that postmenopausal hormone use may decrease the risk for colorectal cancer. Objective: To examine relation of therapy to adenoma and Design: Prospective cohort nested case–control studies. Setting: Nurses' Health Study, a study registered nurses recruited from 11 U.S. states. Participants: 59 002 participants in Study. Measurements: Self-reported data on cases distal cancer obtained biennial questionnaires completed 1980 1994. Cases were confirmed...