A5084579925- Genetic Associations and Epidemiology
- Digestive system and related health
- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Nutritional Studies and Diet
- Hormonal and reproductive studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Child Nutrition and Water Access
- Metabolism, Diabetes, and Cancer
- Atherosclerosis and Cardiovascular Diseases
- Meta-analysis and systematic reviews
- Liver Disease Diagnosis and Treatment
- Burn Injury Management and Outcomes
- COVID-19 epidemiological studies
- Nutrition, Genetics, and Disease
- Bioinformatics and Genomic Networks
- Genetic factors in colorectal cancer
- Frailty in Older Adults
- Ferroptosis and cancer prognosis
- Peroxisome Proliferator-Activated Receptors
University of Ioannina
2020-2024
Aristotle University of Thessaloniki
2016-2024
RELX Group (United States)
2023
Hellenic Agency for Local Development and Local Government
2018
Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due bias. In order examine altered genetically predicted concentration of circulating cytokines associated with development, we performed a two-sample Mendelian randomisation (MR) analysis.
Epidemiological studies have generated conflicting findings on the relationship between glucose-lowering medication use and cancer risk. Naturally occurring variation in genes encoding drug targets can be used to investigate effect of their pharmacological perturbation
To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, thus identifying potential therapeutic targets.
Abstract Background Traditional body-shape indices such as Waist Circumference (WC), Hip (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but correlated Body Mass Index (BMI), adjustment for BMI introduces a strong correlation height. Thus, new allometric have been developed, namely A Shape (ABSI), (HI), (WHI), which uncorrelated weight height; these also CRC risk in observational studies, information from Mendelian randomization (MR) studies is missing....
To investigate whether neurofilament light polypeptide (NfL) level in cerebrospinal fluid (CSF), currently a prognostic biomarker of neurodegeneration patients with multiple sclerosis (MS), may be potential cognitive dysfunction MS.This observational case-control study included MS. CSF levels NfL were determined using enzyme-linked immunosorbent assay. Cognitive function was measured the Brief International Assessment for MS (BICAMS) battery and Paced Auditory Serial Addition Test (PASAT3),...
Abstract Background: Observational evidence has shown that smoking is a risk factor for breast and colorectal cancer. We used Mendelian randomization (MR) to examine causal associations between risks of Methods: Genome-Wide Association Study summary data were identify genetic variants associated with lifetime amount (n = 126 variants) ever having smoked regularly 112 variants). Using two-sample MR, we examined these in relation incident (122,977 cases/105,974 controls) cancer (52,775...
Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases 41,861 controls of European ancestry conduct genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) imputed variants. After adjusting for...
We describe the profile of dietary supplement use and its correlates in Epirus Health Study cohort, which consists 1237 adults (60.5% women) residing urban north-west Greece. The association between demographic characteristics, lifestyle behaviors, personal medical history clinical measurements was assessed using logistic regression models, separately for women men. overall prevalence 31.4%, it higher (37.3%) compared to men (22.4%; p-value = 4.2-08). Based on multivariable associated with...
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which since has over 5 million deaths to date. The pathogenicity of virus highly variable ranging from asymptomatic fatal. Evidence experimental and observational studies suggests that circulating micronutrients may affect COVID-19 outcomes.To complement inform studies, we investigated associations genetically predicted concentrations 12 (β-carotene, calcium, copper, folate,...
Systematic reviews (SRs) have an important role in the healthcare decision-making practice. Assessing overall confidence results of SRs using quality assessment tools, such as "A MeaSurement Tool to Assess Reviews 2" (AMSTAR 2), is crucial since not all are conducted most rigorous methods. In this article, we introduce a free, open-source R package called "amstar2Vis" (https://github.com/bougioukas/amstar2Vis) that provides easy-to-use functions for presenting critical appraisal SRs, based...
Abstract Background Colorectal cancer (CRC) is the third-most-common worldwide and its rates are increasing. Elevated body mass index (BMI) an established risk factor for CRC, although molecular mechanisms behind this association remain unclear. Using Mendelian randomization (MR) framework, we aimed to investigate mediating effects of putative biomarkers other CRC factors in between BMI CRC. Methods We selected as mediators cancer-related which a plausible with obesity exists, such...
Consumption of fibre, fruits and vegetables have been linked with lower colorectal cancer (CRC) risk. A genome-wide gene-environment (G × E) analysis was performed to test whether genetic variants modify these associations.