Christopher I. Amos
A5028989565- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Nutrition, Genetics, and Disease
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- Genetic Mapping and Diversity in Plants and Animals
- Genomic variations and chromosomal abnormalities
- Gene expression and cancer classification
- Occupational and environmental lung diseases
- Cancer Immunotherapy and Biomarkers
- Cutaneous Melanoma Detection and Management
- Genetic and phenotypic traits in livestock
- Cancer-related Molecular Pathways
- Pleural and Pulmonary Diseases
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Genomics and Rare Diseases
- Molecular Biology Techniques and Applications
Houston Institute for Clinical Research
2017-2025
Baylor College of Medicine
2015-2025
Baylor School
2019-2024
The University of Texas MD Anderson Cancer Center
2009-2023
Dartmouth College
2014-2023
Children's Cancer Center
2011-2023
Royal Prince Alfred Hospital
2023
Sydney Local Health District
2023
The University of Texas Health Science Center at Houston
1996-2022
Dartmouth Hospital
2013-2022
Rheumatoid arthritis is a chronic inflammatory disease with substantial genetic component. Susceptibility to has been linked region on chromosome 2q.We tested single-nucleotide polymorphisms (SNPs) in and around 13 candidate genes within the previously 2q for association rheumatoid arthritis. We then performed fine mapping of STAT1-STAT4 total 1620 case patients established 2635 controls, all from North America. Implicated SNPs were further an independent case-control series 1529 early 881...
Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of confounding effect tobacco. Mendelian randomization (MR), or use genetic instrumental variables to assess causality, may help identify drivers cancer. Methods findings We identified instruments for potential risk factors evaluated these in relation using 29,266 cases (including 11,273 adenocarcinomas, 7,426 squamous cell 2,664 small cases) 56,450 controls. The MR analysis suggested a...
Mutations in the BRCA1 and BRCA2 genes confer greater risk of developing breast cancer. We determined whether tumor pathologic features clinical differ patients with without BRCA mutations.Tumor characteristics were examined 491 women cancer who underwent genetic testing for mutations between 1997 2006. A retrospective review medical records was conducted to determine including ethnicity, age stage at diagnosis, parity, number full-term pregnancies, use oral contraceptives hormone...
Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there significant genetic predisposition to primary cirrhosis, but the susceptibility loci are unknown.To identify conferring risk for we carried out genomewide association analysis in which DNA samples from 2072 Canadian U.S. subjects (536 patients 1536 controls) were genotyped more than 300,000 single-nucleotide...
BackgroundReliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool by smoking status.
An accurate evaluation of the penetrance BRCA1 and BRCA2 mutations is essential to identification clinical management families at high risk breast ovarian cancer. Existing studies have focused on Ashkenazi Jews (AJ) or from outside United States. In this article, we consider US population using largest US-based cohort date both AJ non-AJ families.We collected 676 1,272 other ethnicities through Cancer Genetics Network. Two hundred eighty-two were based, whereas remainder was counseling...