A5058502526- Statistical Methods and Inference
- Statistical Methods in Clinical Trials
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Advanced Causal Inference Techniques
- Statistical Methods and Bayesian Inference
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Ovarian cancer diagnosis and treatment
- Global Cancer Incidence and Screening
- HIV/AIDS drug development and treatment
- Colorectal and Anal Carcinomas
- Glioma Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Estrogen and related hormone effects
Corvia Medical (United States)
2023
Harvard University Press
1998-2022
Massachusetts General Hospital
2012-2022
Harvard University
2010-2022
Boston University
2005-2022
Dana-Farber Cancer Institute
1989-2015
The University of Sydney
2015
The University of Texas Health Science Center at San Antonio
2015
University of Kansas Medical Center
2015
University of Alabama
2015
Gliomas are common malignant neoplasms of the central nervous system. Among major subtypes gliomas, oligodendrogliomas distinguished by their remarkable sensitivity to chemotherapy, with approximately two thirds anaplastic (malignant) responding dramatically combination treatment procarbazine, lomustine, and vincristine (termed PCV). Unfortunately, no clinical or pathologic feature these tumors allows accurate prediction response chemotherapy. Anaplastic also a unique constellation molecular...
In the present study, we aimed to determine frequency of a significant reduction in urinary albumin excretion and factors affecting such patients with type 1 diabetes microalbuminuria.
Summary. AIDS Clinical Trial Group (ACTG) randomized trial 021 compared the effect of bactrim versus aerosolized pentamidine (AP) as prophylaxis therapy for pneumocystis pneumonia (POP) in patients. Although patients to arm experienced a significant delay time POP, survival experience two arms was not significantly different ( p = .32). In this paper, we present evidence that improves but standard intent‐to‐treat comparison failed detect advantage because large fraction subjects either...
(2005). A Beginner's Guide to Structural Equation Modeling. Technometrics: Vol. 47, No. 4, pp. 522-522.
This paper develops a method for fitting the proportional hazards regression model when data contain left-, right-, or interval-censored observations. Results given testing hypothesis of zero coefficient lead to generalization log-rank test comparison several survival curves. The is used analyze from an animal tumorigenicity study and also clinical trial.
Different prognostic factors stratify patients with pancreatic adenocarcinoma. The purpose of this study was to determine whether preoperative CA19-9 levels can predict stage disease or survival and a change in postoperative the predicts overall survival.Four hundred twenty-four consecutive adenocarcinoma underwent resection between January 1, 1985 2004. Of bilirubin less than 2 mg/dL, 176 had values, 111 pre- values. Survival measured from first level (median, 39 days) until death last...
We examined the role of electrophysiologic testing in prediction long-term outcome 166 survivors out-of-hospital cardiac arrest not associated with acute myocardial infarction. Ventricular arrhythmias were inducible 131 patients (79 percent) at base line and suppressed by antiarrhythmic drugs or surgery (or both) 91 127 (72 percent). During a median follow-up period 21 months, recurred 29 patients: 11(12 whom had been (including 5 treatment discontinued), 12 (33 36 persisted, 6 (17 35 could...
The identification of patients with metastatic triple-negative breast cancer (mTNBC) who are expected to benefit from platinum-based chemotherapy is interest. We conducted a single-arm phase II clinical trial single-agent platinum for mTNBC biomarker correlates.Patients received first- or second-line cisplatin (75 mg/m(2)) carboplatin (area under the concentration-time curve 6) by physician's choice once every 3 weeks. Coprimary end points were objective response rate (RR) and prediction...
Mutations in a germ-line allele of the BRCA1 gene contribute to familial breast cancer syndrome. However, prevalence these mutations is unknown women with who do not have features this We sought were given diagnosis at an early age, because onset characteristic genetic predisposition cancer.
Between October 1981 and June 1983, the Eastern Cooperative Oncology Group (ECOG) conducted a prospectively randomized trial (EST 1581) of four most active chemotherapy regimens for metastatic non-small-cell lung cancer (NSCLC). Four hundred eighty-six good performance status patients (PS 0 or 1; 81%) were to receive cyclophosphamide, doxorubicin, methotrexate, procarbazine (CAMP); mitomycin, vinblastine, cisplatin (MVP); etoposide (VP-P); vindesine (VDA-P). All administered in doses...
Between December 1979 and June 1983 the Eastern Cooperative Oncology Group (ECOG) treated 893 good-performance status patients with metastatic non-small-cell lung cancer (NSCLC) on one of seven phase III combination chemotherapies. The overall median survival was 23.5 weeks no significant differences between treatments. One hundred sixty-eight (19%) survived greater than 1 year 36 (4%) for 2 years. etoposide-platinum had highest proportion 1-year survivors (25%)....
An accurate evaluation of the penetrance BRCA1 and BRCA2 mutations is essential to identification clinical management families at high risk breast ovarian cancer. Existing studies have focused on Ashkenazi Jews (AJ) or from outside United States. In this article, we consider US population using largest US-based cohort date both AJ non-AJ families.We collected 676 1,272 other ethnicities through Cancer Genetics Network. Two hundred eighty-two were based, whereas remainder was counseling...
We address the prognostic and predictive value of KRAS, PIK3CA BRAF mutations for clinical outcomes in response to active agents treatment metastatic colorectal cancer (mCRC).We determined tumours from 168 patients treated mCRC at two institutions. All received 5-FU-based first-line chemotherapy outcome was analysed retrospectively.KRAS, were present 62 (37%), 13 (8%) 26 (15%) cases, respectively. Multivariate analysis uncovered mutation as an independent factor decreased survival (hazard...
Pneumocystis carinii pneumonia (PCP) continues to be the most common index diagnosis in acquired immunodeficiency syndrome (AIDS), but it is not clear which of several available agents effective preventing a recurrence PCP.
We evaluated the effectiveness of three treatment strategies for prevention a first episode Pneumocystis carinii pneumonia in patients infected with human immunodeficiency virus (HIV).
Cryptococcal meningitis and other serious fungal infections are common complications in patients infected with the human immunodeficiency virus (HIV). Fluconazole is effective for long-term suppression of many infections, but its effectiveness as primary prophylaxis had not been adequately evaluated.We conducted a prospective, randomized trial that compared fluconazole (200 mg per day) clotrimazole troches (10 taken five times daily) who were also participating Pneumocystis carinii...
During the last decade, Eastern Cooperative Oncology Group (ECOG) has studied a series of combination chemotherapy regimens in metastatic (stage IV) non-small-cell lung cancer (NSCLC). In January 1984, ECOG activated randomized study, EST 1583, which concluded evaluation phase III trials and initiated single agents exclusively previously untreated patients. The treatment 1583 consisted of: (1) mitomycin, vinblastine, cisplatin (MVP); (2) vinblastine (VP); (3) MVP alternating with regimen...
Clinical trials often assess therapeutic benefit on the basis of an event such as death or diagnosis disease. Usually, there are several additional longitudinal measures clinical status which collected to be used in treatment comparison. This paper proposes a simple non-parametric test combines time measure and so that substantial difference either will reject null hypothesis. The is applied AIDS prophylaxis paediatric trials.