A5030242553- Palliative Care and End-of-Life Issues
- Palliative and Oncologic Care
- Pain Management and Opioid Use
- Ethics and bioethics in healthcare
- Opioid Use Disorder Treatment
- Adipose Tissue and Metabolism
- Family and Patient Care in Intensive Care Units
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Psychosomatic Disorders and Their Treatments
- Healthcare Decision-Making and Restraints
- Immune Cell Function and Interaction
- Geriatric Care and Nursing Homes
- Pain Mechanisms and Treatments
- Neurological and metabolic disorders
- Pediatric Pain Management Techniques
- Pharmaceutical Practices and Patient Outcomes
- Melanoma and MAPK Pathways
- Heart Failure Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Childhood Cancer Survivors' Quality of Life
- Cancer Treatment and Pharmacology
- Cardiac Fibrosis and Remodeling
- IL-33, ST2, and ILC Pathways
- Soft tissue tumors and treatment
Spanish National Cancer Research Centre
2024-2025
Spanish National Centre for Cardiovascular Research
2019-2025
Universidad de La Sabana
2011-2024
Centro Nacional de Epidemiología
2024
Hospital Universitario Insular de Gran Canaria
2024
Universidad Nacional de Colombia
2023
Universidad El Bosque
2023
Hospital Clínico Universitario Lozano Blesa
2022
Secretaría de Salud de Bogotá
2022
To evaluate whether the addition of hydrochlorothiazide (HCTZ) to intravenous furosemide is a safe and effective strategy for improving diuretic response in acute heart failure (AHF).A prospective, double-blind, placebo-controlled trial, including patients with AHF randomized receive HCTZ or placebo an regimen. The coprimary endpoints were changes body weight patient-reported dyspnoea 72 h after randomization. Secondary outcomes included metrics mortality/rehospitalizations at 30 90 days....
Obesity poses a global health challenge, demanding deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role mitochondrial protein Methylation-controlled J (MCJ/DnaJC15) in orchestrating brown (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident human mouse samples. MCJKO mice, even without UCP1, fundamental thermogenic protein, exhibit elevated BAT Electron microscopy unveils changes morphology resembling activation....
Aims To evaluate the synergistic impact of diet, lifestyle and technology on glycemic control in children with type 1 diabetes (T1D). Methods This cross-sectional study included 112 randomly selected patients T1D from Gran Canaria (median age 12 years; 51.8% female). The collected data height, weight, body composition (bioimpedance), age, disease duration, method insulin delivery. Physical activity was evaluated using Krece questionnaire an accelerometer (GENEActiv). Adherence to...
Pulmonary hypertension (PH) can affect both pulmonary arterial tree and cardiac function, often leading to right heart failure death. Despite the urgency, lack of understanding has limited development effective therapeutic strategies. Our research reveals that MCJ modulates mitochondrial response chronic hypoxia. levels elevate under hypoxic conditions, as in lungs patients affected by COPD, mice exposed hypoxia, myocardium from pigs subjected ventricular (RV) overload. The absence preserves...
Stress-activated p38 kinases control a plethora of functions, and their dysregulation has been linked to the development steatosis, obesity, immune disorders, cancer. Therefore, they have identified as potential targets for novel therapeutic strategies. There are four family members (p38α, p38β, p38γ, p38δ) that activated by MKK3 MKK6. Here, we demonstrate lack MKK6 reduces lifespan in mice. Longitudinal study cardiac function KO mice showed young develop hypertrophy which progresses...
Access to palliative care is insufficient in many countries around the world. In an effort improve access services and treatments, a public health approach as suggested by World Health Organization was implemented Colombia opioid availability, increase awareness competences about for healthcare workers, include component of legislation. As result, availability has improved, mandatory course medical undergraduate students been law being discussed Senate. This article describes strategy, main...
Background: Patients requiring home-based palliative care have advanced complex illnesses with functional limitations and decline. This retrospective study reviewed caregiver administration of subcutaneous (SQ) medications fluids when symptom control could not be achieved using the oral route. Methods: Medical records from September 1, 2017 to February 28, 2018 were for 272 consecutive patients who received SQ or at a program. We analyzed clinical characteristics caregivers, administered,...
Due to the increase in prevalence of non-communicable diseases and Colombian demographic transition, necessity palliative care has arisen. This study used accessibility coverage indicators measure geographic barriers care.
Skeletal muscle has gained recognition as an endocrine organ releasing myokines upon contraction during physical exercise. These exert both local and pleiotropic health benefits, underscoring the crucial role of function in countering obesity contributing to overall positive effects exercise on health. Here, we found that activates p38γ, increasing locomotor activity through secretion interleukin-15 (IL-15). IL-15 signals motor cortex, stimulating activity. This activation leading increase...
The prevalence of neuropathic pain requires proposals for management guidelines. In some cases, the degree severity and difficulty treating this disorder has resulted in poor quality life. Europe, reported is 5%, chronic postoperative ranges between 5% 85%, depending on type surgery. purpose paper to review pharmacological options pathophysiology, suggest therapeutical approaches with medications available Colombia, included or not Mandatory Health Plan. El dolor neuropático es una patología...
This study aimed to identify barriers access palliative care through a social mapping approach. In Colombia, the denote an enormous geographic disparity of resources and health needs, making it necessary conduct community-based participatory research using approach such as mapping. A qualitative design was used. Stakeholders from insurance companies, regulatory authorities, regional secretariats, professionals, patient caregiver organizations, scientific societies, medical journalists 7...