A5011795804- Parathyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
- Hypertrophic osteoarthropathy and related conditions
- Fibroblast Growth Factor Research
- SARS-CoV-2 and COVID-19 Research
- Genetic Syndromes and Imprinting
- Pericarditis and Cardiac Tamponade
- Cardiovascular Function and Risk Factors
- Blood properties and coagulation
- Aortic Thrombus and Embolism
- Renal Diseases and Glomerulopathies
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Frailty in Older Adults
- Dermatological and Skeletal Disorders
- Dialysis and Renal Disease Management
- Systemic Sclerosis and Related Diseases
- COVID-19 and healthcare impacts
- Travel-related health issues
- Biomedical Research and Pathophysiology
- Bone health and osteoporosis research
- Diabetes Treatment and Management
Hospital Universitario Nuestra Señora de Candelaria
2017-2025
Universidad de La Laguna
2019-2021
Hospital General de Niños Ricardo Gutierrez
2018
To evaluate whether the addition of hydrochlorothiazide (HCTZ) to intravenous furosemide is a safe and effective strategy for improving diuretic response in acute heart failure (AHF).A prospective, double-blind, placebo-controlled trial, including patients with AHF randomized receive HCTZ or placebo an regimen. The coprimary endpoints were changes body weight patient-reported dyspnoea 72 h after randomization. Secondary outcomes included metrics mortality/rehospitalizations at 30 90 days....
Decrease in soluble anti-aging Klotho protein levels is associated to cardiovascular disease (CVD).Diverse studies have shown a bidirectional relationship between and inflammation, risk factor for the development of CVD.In this work we aimed evaluate association inflammatory cytokines context human CVD.The study included 110 patients with established CVD preserved renal function, control group 22 individuals without previous history events.Serum IL10 were significantly lower...
We aimed to determine the impact of tocilizumab use on severe COVID-19 (coronavirus disease 19) pneumonia mortality. performed a multicentre retrospective cohort study in 18 tertiary hospitals Spain from March April 2020. Consecutive patients admitted with treated were compared not tocilizumab, adjusting by inverse probability treatment weights (IPTW). Tocilizumab's effect receiving steroids during 48 h following inclusion was analysed. During period, 506 fulfilled criteria. Among them, 268...
Abstract Cardiovascular disease is the leading cause of death worldwide. New therapeutic strategies are aimed to modulate athero-inflammatory process that partially orchestrates underlying vascular damage. Peripheral blood circulating cells include different immune with a central role in development atherogenic inflammatory response. The anti-aging protein α-Klotho has been related protective effects against CVD. KL expressed monocytes, macrophages, and lymphocytes where it exerts...
Atherosclerosis is a chronic inflammatory disorder affecting the artery wall. Klotho, an anti-aging factor expressed in vessel walls that participates maintenance of vascular homeostasis, can be down-regulated by inflammation. In this proof-of-concept work we seek to characterize arterial KLOTHO expression wall, as well serum concentration protein, group patients with clinical atherosclerotic disease. addition, aim analyze relationship between Klotho and Vascular samples were obtained from...
Vascular calcification is a major risk for cardiovascular disease and implies the transformation of smooth muscle cells to an osteoblastic phenotype as consequence dysregulation calcium phosphate metabolism.Fibroblast growth factor (FGF) 23 most potent regulator.Observational studies suggest that high levels FGF23 are related morbidity mortality.In this work, we determined both intact carboxi-terminal fragments circulating in 133 patients with established disease, expression FGF23, its...
Fibroblast growth factor 23 (FGF23) levels are often elevated in chronic kidney disease (CKD). FGF23 and inflammation common characteristics CKD, both associated with worse progression the occurrence of complications. The existence an interaction between has been suggested, each which influences expression activity other, leading to a vicious feedback loop adverse outcomes, including cardiovascular mortality. In this work, we determined circulating group patients CKD stages 3 4 subjected...
The triglyceride-glucose (TyG) index has been proposed as an independent predictor of coronary artery disease (CAD). In this retrospective study we further examine association and its utility a for major adverse cardiovascular events (MACE). A total 870 patients who underwent angiography between May 2008 June 2009 were included in study. TyG was calculated using the formula Ln (fasting TG [mg/dL] × FBG [mg/dL]/2). with presence severity CAD, risk factors, inflammatory markers evaluated at...
Diabetic foot syndrome (DFS) is a prevalent complication in the diabetic population and major cause of hospitalizations. Diverse clinical studies have related alterations system formed by fibroblast growth factor (FGF)-23 Klotho (KL) with vascular damage. In this proof-of-concept study, we hypothesize that levels FGF23 are altered DFS patients.Twenty patients limb amputation due to DFS, 37 without 12 non-diabetic cadaveric organ donors were included study. Serum FGF23/Klotho inflammatory...
Malnutrition is highly prevalent in hospitalized patients and results a worsened clinical course as well an increased length of stay, mortality, costs. Therefore, simple nutrition screening systems, such CIPA (control food intake, protein, anthropometry), may be implemented to facilitate the patient's recovery process. The aim this study evaluate effectiveness cost-effectiveness implementing tool tertiary hospital, consistent with lack similar, published studies on any hospital system.The...
ABSTRACT Background We aimed to determine the impact of tocilizumab use in severe COVID-19 pneumonia mortality. Methods performed a multicentre retrospective cohort study 18 tertiary hospitals Spain, from March April 2020. Consecutive patients admitted with treated were compared not tocilizumab, adjusting by Inverse Probability Treatment Weights (IPTW). Tocilizumab effect receiving steroids during 48h following inclusion was analyzed. Results During period, 506 fulfilled criteria. Among...
Hospital malnutrition is very common and worsens the clinical course of patients while increasing costs. Lacking clinical-economic studies on implementation nutrition screening encouraged evaluation CIPA (Control Food Intake, Protein, Anthropometry) tool.An open, non-randomized, controlled trial was conducted admitted to internal medicine general digestive surgery wards, who were either assigned a control (standard hospital care) or an intervention, CIPA-performing ward (412 411,...
El paricalcitol, un activador selectivo del receptor de la vitamina D, se utiliza en el tratamiento hiperparatiroidismo secundario trasplante renal. Estudios tanto clínicos como experimentales realizados pacientes renales no trasplantados muestran propiedades antiinflamatorias para esta molécula. En este estudio exploratorio, hemos evaluado perfil antiinflamatorio paricalcitol receptores Treinta y con completaron 3 meses terapia oral (1 μg/día). Se determinaron las concentraciones séricas...
Abstract Background and Aims Diabetes mellitus (DM) chronic kidney disease (CKD) are risk factors for vascular atherosclerosis, a pathological process with an important inflammatory component. The coexistence of these conditions in patients diabetic (DKD) has additive effects worst cardiovascular mortality morbidity rates when compared to non-diabetic CKD patient on outcomes. Accumulating research shown that increased levels bone-derived fibroblast growth factor 23 (FGF23), the major...
Paricalcitol, a selective vitamin D receptor activator, is used to treat secondary hyperparathyroidism in kidney transplant patients. Experimental and clinical studies non-transplant disease patients have found this molecule anti-inflammatory properties. In exploratory study, we evaluated the profile of paricalcitol kidney-transplant recipients. Thirty one recipients with completed 3 months treatment oral (1 μg/day). Serum concentrations gene expression levels inflammatory cytokines...
Abstract Background and Aims Klotho (KL) is a transmembrane protein that expressed the highest in tubular cells of kidneys. In addition to membrane KL, secreted form this present blood urine generated by ectodomain shedding KL from cell surface or gene through alternative splicing. Preserved expression has been related physiological protection human Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are new class antidiabetic drugs with important renal benefits. The aim proof-of-concept...
Abstract Cardiovascular disease (CVD) is the leading cause of death worldwide. New therapeutic strategies are aimed to modulate athero-inflammatory process that partially orchestrates underlying vascular damage. Peripheral blood circulating cells (PBCCs) include different immune with a central role in development atherogenic inflammatory response. The anti-aging factor α-Klotho (KL) has been related protective effects against CVD. KL expressed monocytes, macrophages and lymphocytes where it...