A5085573664- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Pharmaceutical studies and practices
- Renal Transplantation Outcomes and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Organ Donation and Transplantation
- Heart Failure Treatment and Management
- Heart rate and cardiovascular health
- Medication Adherence and Compliance
- Nutritional Studies and Diet
- Pharmacogenetics and Drug Metabolism
- Dialysis and Renal Disease Management
- Pharmacovigilance and Adverse Drug Reactions
- Potassium and Related Disorders
- Poisoning and overdose treatments
- Colorectal Cancer Screening and Detection
- Blood disorders and treatments
- Forensic Toxicology and Drug Analysis
- Diet, Metabolism, and Disease
- Food composition and properties
- COVID-19 Clinical Research Studies
- Cardiac Ischemia and Reperfusion
Hospital del Mar Research Institute
2018-2025
Hospital Del Mar
2018-2025
Pompeu Fabra University
2023-2025
Municipal Institute for Medical Research
2021-2022
Hospital Universitario de Canarias
2010-2021
Universitat Autònoma de Barcelona
2020-2021
Parc de Salut
2020
Servicio Canario de la Salud
2010-2019
The University of Texas Health Science Center at San Antonio
2017
Hélio Alonso University
2017
The MARIA randomized trial evaluated the efficacy and safety of melatonin for reduction reperfusion injury in patients undergoing revascularization ST-elevation myocardial infarction (STEMI). This was a prespecified interim analysis. A total 146 presenting with STEMI within 6 hours chest pain onset were to receive intravenous intracoronary (n=73) or placebo during primary percutaneous coronary intervention (PPCI). Primary endpoint infarct size as assessed by magnetic resonance imaging (MRI)...
Objectives: Inadequate bowel cleansing is a major burden for endoscopy units. The aim of this study was to compare two intensive regimens in patients with previous colonoscopy inadequate preparation. Methods: Patients at index were randomized 4-L split-dose polyethylene-glycol (PEG) regimen vs. 2-L PEG plus ascorbic acid (PEG+Asc) regimen. All individuals underwent 3-day low-residue diet and received 10 mg bisacodyl, the day before colonoscopy. Cleansing considered be adequate if Boston...
We aimed to determine the impact of tocilizumab use on severe COVID-19 (coronavirus disease 19) pneumonia mortality. performed a multicentre retrospective cohort study in 18 tertiary hospitals Spain from March April 2020. Consecutive patients admitted with treated were compared not tocilizumab, adjusting by inverse probability treatment weights (IPTW). Tocilizumab's effect receiving steroids during 48 h following inclusion was analysed. During period, 506 fulfilled criteria. Among them, 268...
Abstract Aims The aim of the LAICA study was to evaluate long‐term effectiveness and safety intermittent levosimendan infusion in patients with advanced heart failure (AdHF). Methods results This a multicentre, randomized, double‐blind, placebo‐controlled clinical trial 0.1 μg/kg/min as continuous 24‐h intravenous administered once monthly for 1 year AdHF. primary endpoint [incidence rehospitalization (admission emergency department or hospital ward >12 h) acute decompensated HF...
ABSTRACT The detection of endogenous anabolic androgenic steroids (EAAS) is performed with the Steroidal Module Athlete Biological Passport (ABP). Glucocorticoids (GC) could be a confounding factor to ABP because they inhibit hypothalamic–pituitary–adrenal axis, and metabolites have partial adrenal origin. In previous studies, single‐dose systemic GC administrations been shown reduce urinary ratios A/T 5αdiol/E. this work, impact repeated oral doses GCs on steroid profile (SP) has evaluated....
PurposeAlthough some caregivers are using epigallocatechin gallate (EGCG) off label in hopes of improving cognition young adults with Down syndrome (DS), nothing is known about its safety, tolerability, and efficacy the DS pediatric population. We aimed to evaluate safety tolerability a dietary supplement containing EGCG if improves cognitive functional performance.MethodsA total 73 children (aged 6-12 years) were randomized. Participants received 0.5% (10 mg/kg daily dose) or placebo for 6...
Chronic kidney disease (CKD) affects 10–13% of the population worldwide. CKD classification stratifies patients in five stages risk for progressive renal based on estimated glomerular filtration rate (eGFR) by formulas and albuminuria. However, reliability to reflect real function is a matter debate. The effect error unclear, particularly cystatin C–based equations. We evaluated large number C and/or creatinine-based definition 882 subjects with different clinical situations over wide range...
Beer and wine contains the simple phenol tyrosol (TYR) which is endogenously converted into hydroxytyrosol (HT), one of strongest dietary antioxidants, by CYP2A6 CYP2D6 polymorphic enzymes. We investigated in humans rate this bioconversion after beer red (RW) intake. In a single blind, randomized, crossover, controlled clinical trial (n = 20 healthy subjects), we evaluated TYR absorption biotransformation HT following dose (i) RW, (ii) Indian pale ale (IPA), (iii) blonde beer, (iv)...
Formulas do not estimate renal function with acceptable precision and accuracy.We compared 51 creatinine-based and/or cystatin c-based formulas a gold standard (iohexol plasma clearance) in 193 transplant recipients using concordance correlation coefficient, total deviation index, coverage probability the error chronic kidney disease (CKD) stage classification.No formula showed coefficient greater than 0.90 (average for formulas: ∼0.70 ∼0.85). A wide index was observed: approximately 70%...
The development of clinical practice recommendations or guidelines for the use biomarkers is an issue great importance with regard to adverse drug reactions. potential pharmacogenomic has been extensively investigated in recent years. However, several barriers implementing pharmacogenomics testing exist. We conducted a survey among members Spanish Societies Pharmacology and Clinical obtain information about perception such compare perceptions participants relative major gene/drug pairs. Of...
Advanced heart failure (HF) is associated with high morbidity and mortality; it represents a major burden for the health system. Episodes of acute decompensation requiring frequent prolonged hospitalizations account most HF-related expenditure. Inotropic drugs are frequently used during hospitalization, but rarely in out-patients. The LAICA clinical trial aims to evaluate effectiveness safety monthly levosimendan infusion patients advanced HF reduce incidence hospital admissions...
Reliable determination of glomerular filtration rate (GFR) is crucial in the evaluation living kidney donors. Although some guidelines recommend use measured GFR (mGFR), many centres still rely on estimated (eGFR) obtained through equations or 24-h creatinine clearance. However, eGFR neither accurate nor precise reflecting real renal function. We analysed impact errors and decision making regarding potential evaluated 103 consecutive donors who underwent mGFR via iohexol plasma clearance by...
ABSTRACT Background We aimed to determine the impact of tocilizumab use in severe COVID-19 pneumonia mortality. Methods performed a multicentre retrospective cohort study 18 tertiary hospitals Spain, from March April 2020. Consecutive patients admitted with treated were compared not tocilizumab, adjusting by Inverse Probability Treatment Weights (IPTW). Tocilizumab effect receiving steroids during 48h following inclusion was analyzed. Results During period, 506 fulfilled criteria. Among...
The Mediterranean diet, featuring sourdough bread, shows promise in managing metabolic syndrome. This study explored the effects of two breads, with differing fermentation times but similar nutritional profiles, on inflammation, satiety, and gut microbiota composition adults In a double-blind clinical trial, participants were randomized to consume either Elias Boulanger
Abstract Background Lifestyle interventions targeting multiple Alzheimer’s disease (AD) risk factors are effective strategies to prevent cognitive decline. Emerging evidence suggests synergistic effects between various intervention components, including lifestyle modifications, supplements, and pharmacological approaches. The PENSA study, part of the World‐Wide FINGERs network, is a randomized, double‐blind clinical trial following Finger 2.0 Model. This work aims show results effectiveness...