A5045219815- Liver Disease Diagnosis and Treatment
- Iron Metabolism and Disorders
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- Folate and B Vitamins Research
- Hepatitis C virus research
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Celiac Disease Research and Management
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Hepatitis Viruses Studies and Epidemiology
- Pharmacogenetics and Drug Metabolism
- Microscopic Colitis
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis B Virus Studies
- Systemic Lupus Erythematosus Research
- Amoebic Infections and Treatments
- Porphyrin Metabolism and Disorders
- Eosinophilic Esophagitis
- Pancreatic and Hepatic Oncology Research
- SARS-CoV-2 and COVID-19 Research
Biogipuzkoa Health Research Institute
1998-2024
Donostia Unibertsitate Ospitalea
2018-2024
Hospital San Pedro
2009-2023
Hospital Universitario Virgen de las Nieves
2016
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2014-2016
Universidad de Málaga
2014-2016
Complejo Hospitalario Universitario de Albacete
2016
Instituto de Investigación Biomédica de Málaga
2014-2016
Masermic (Spain)
2015
Hospital Comarcal de Inca
2002-2010
Distinguishing drug-induced liver injury (DILI) from idiopathic autoimmune hepatitis (AIH) can be challenging. We performed a standardized histologic evaluation to explore potential hallmarks differentiate AIH versus DILI. Biopsies patients with clinically well-characterized DILI [n = 35, including 19 hepatocellular (HC) and 16 cholestatic/mixed (CS)] (n 28) were evaluated for Ishak scores, prominent inflammatory cell types in portal intra-acinar areas, the presence or absence of...
Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis 843 patients with DILI enrolled into the Spanish Registry over 20-year time period.Cases were identified, diagnosed and followed prospectively. Clinical features, drug outcome data collected.A total patients, mean age 54 years (48% females), up 2018. Hepatocellular was associated younger (adjusted odds ratio [aOR] per year 0.983; 95%...
To evaluate the accuracy of magnetic resonance (MR) imaging in quantification hepatic iron concentration.Between April 1999 and June 2001, 112 patients were recruited prospectively. All had undergone liver biopsy concentration with spectrophotometry, followed by MR imaging. involved use four gradient-echo sequences one spin-echo sequence. Signal intensity (SI) was measured on images obtained each sequence means regions interest placed paraspinal muscle to obtain liver-to-muscle SI ratio. The...
Individual vulnerability to drug-induced liver injury (DILI) might result from deficiencies in the detoxification process, which determines level of exposure reactive metabolite. We evaluated whether a genetically determined reduction ability detoxify electrophilic compounds, such as that expected among individuals with glutathione S-transferase (GST) null genotypes, play role determining risk for DILI and its clinical expression. Genomic DNA 154 patients (74 men, 80 women; mean age, 53...
Amoxicillin-clavulanate (AC) hepatotoxicity has been reported to exhibit a higher predominance of cholestatic types damage, especially in males. However, the determinants its clinical expression are unknown. This study prospectively evaluated profile AC hepatotoxicity. Data on all cases Spanish Registry attributed and assessed as definite or probable Council for International Organizations Medical Sciences (CIOMS) scale were collated compared published case series. Hepatotoxicity related...
The aetiology of autoimmune hepatitis (AIH) is uncertain but the disease can be triggered in susceptible patients by external factors such as viruses or drugs.AIH usually develops individuals with a genetic background mainly consisting some risk alleles major histocompatibility complex (HLA).Many drugs have been linked to AIH phenotypes, which sometimes persist after drug discontinuation, suggesting that they awaken latent autoimmunity.At least three clinical scenarios proposed refers...
Abstract Background & Aims The current definition of the pattern liver injury in hepatotoxicity ( DILI ) is given by R (ratio) value, dividing alanine aminotransferase ALT and alkaline phosphatase ALP upper limits normal at onset. We aimed to explore validity using aspartate AST gamma‐glutamyl transpeptidase GGT as biomarkers hepatocelullar cholestatic damage, respectively, when calculating value. Methods Clinical, laboratory histological data from 588 episodes included Spanish Registry...
Measurement of liver iron concentration is a key parameter for the management patients with primary and secondary haemochromatosis. Magnetic resonance imaging (MRI) has already demonstrated high accuracy to quantify content. To be able improve current that are found have overload, we need reproducible, standardised method is, or can easily made, widely available.This article discusses different MRI techniques models currently available envisaged near future from realistic perspective.T2...
Abstract Background & aims Idiosyncratic drug‐induced liver injury (DILI) with autoimmune features is a condition laboratory and histological characteristics similar to those of idiopathic hepatitis (AIH), which despite being increasingly reported, remains largely undefined. We aimed describe in‐depth the this entity in large series patients from two prospective DILI registries. Methods cases collected Spanish Registry Latin American Network were compared without an independent cohort...
Helicobacter pylori is the major cause of peptic ulcer disease, but proportion H. pylori-negative ulcers seems to be increasing in developed countries. We investigated frequency without intake nonsteroidal anti-inflammatory drugs (NSAIDs) a Mediterranean European country.We prospectively collected consecutive patients with an endoscopically verified active over 6 months from different areas Spain. infection was assessed by rapid urease test and histologic examination (corpus antral...
Positive autoantibody (AAB) titres are commonly encountered in autoimmune hepatitis (AIH) and a proportion of drug-induced liver injury (DILI) patients. The underlying mechanism for selective AAB occurrence DILI is unknown, but could be associated with variations immune-associated genes. Hence, we aimed to analyse human leucocyte antigen (HLA) allele compositions positive (+) negative (-) AIH patients.High-resolution genotyping HLA class I (A, B, C) II (DRB1, DQB1) loci was performed on 207...
Different patterns of liver injury have been reported in association with the SARS-CoV-2 vaccines. The aim this study was to describe a nationwide cohort patients SARS CoV-2 vaccine-induced injury, focusing on treatment and evolution after further booster administration. multicentre, retrospective-prospective study, including subjects who developed abnormal tests within 90 days administration vaccination. 47 cases were collected: 17 prime dose 30 booster. Age 57 years, (63.8%) female, 7...
Background: An association between Helicobacter pylori infection and heart disease has been suggested. A potential mechanism may be inflammation‐induced atherogenic changes of lipoproteins, but epidemiological studies have provided conflicting results. Methods: In a prospective multicentre study, 830 patients submitted for endoscopy H. testing were evaluated. Of the 686 ‐positive patients, 487 received 199 did not receive eradication treatment. Serum lipids plasma fibrinogen measured at...