A5017174323- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Liver Diseases and Immunity
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Alcohol Consumption and Health Effects
- Pancreatitis Pathology and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Renal Diseases and Glomerulopathies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Drug Transport and Resistance Mechanisms
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lymphoma Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
King's College Hospital
2015-2025
King's College London
2015-2025
University College London
2015-2025
Hospital Universitario de Canarias
2007-2025
King's College Hospital NHS Foundation Trust
2019-2024
Hospital Universitari de Girona Doctor Josep Trueta
2023
Universidad Complutense de Madrid
2023
Hospital Universitario Infanta Sofía
2023
Medical Research Council
2015-2022
Universitat de Barcelona
2007-2021
Helical computerized tomography (CT) and magnetic resonance imaging (MRI) are used for staging of hepatocellular carcinoma (HCC) prior to curative treatments but underestimate tumor extension in 30% 50% cases when compared with pathologic explants. This study compares a new technology, MRI angiography (MRA), triphasic helical CT detection HCC. Fifty cirrhotic patients, 29 HCC, undergoing liver transplantation were analyzed. MRA was performed 3–D breath–hold fast spoiled gradient–echo...
Current therapies for chronic hepatitis C virus (HCV) in HIV co-infected patients have a low success rate and are poorly tolerated. We evaluated the efficacy safety of interferon alfa-2b (IFN) + ribavirin (RBV) versus pegylated (PEG-INF) RBV.Randomized, single-centre, open-label clinical trial including with: detectable HCV-RNA, alanine aminotransferase > 1.5-fold upper limit normal, abnormal liver histology, CD4 cell count 250 x 10/l RNA < 10 000 copies/ml. Patients were assigned to INF (3...
Distinguishing drug-induced liver injury (DILI) from idiopathic autoimmune hepatitis (AIH) can be challenging. We performed a standardized histologic evaluation to explore potential hallmarks differentiate AIH versus DILI. Biopsies patients with clinically well-characterized DILI [n = 35, including 19 hepatocellular (HC) and 16 cholestatic/mixed (CS)] (n 28) were evaluated for Ishak scores, prominent inflammatory cell types in portal intra-acinar areas, the presence or absence of...
Prognostic stratification of patients with alcoholic hepatitis (AH) may improve the clinical management and facilitate trials. We aimed at developing a scoring system capable providing prognostic AH.Patients biopsy-proven AH were prospectively included between 2000 2006. The biochemical, clinical, portal hemodynamic histological parameters evaluated. A Cox regression model was used for univariate multivariate analyses. predictive score built using variables obtained admission identified in...
Lifelong immunosuppression increases morbidity and mortality in liver transplantation. Discontinuation of immunosuppressive drugs could lessen this burden, but the safety, applicability, clinical outcomes strategy need to be carefully defined. We enrolled 102 stable recipients at least 3 years after transplantation a single-arm multicenter withdrawal trial. Drugs were gradually discontinued over 6 9-month period. The primary endpoint was development operational tolerance, defined as...
Portal hypertension, the most important complication in patients with cirrhosis of liver, is a serious and life-threatening disease for which there are few therapeutic options. Because angiogenesis pathological hallmark portal goal this study was to determine effects sorafenib-a potent inhibitor proangiogenic vascular endothelial growth factor receptor 2 (VEGFR-2), platelet-derived beta (PDGFR-beta), Raf kinases-on splanchnic, intrahepatic, systemic, portosystemic collateral circulations two...
To determine the clinicopathologic significance of Kikuchi-Fujimoto disease (KFD) and review literature on this condition, we conducted a MEDLINE search English-language articles published between 1972 December 2003. KFD has worldwide distribution, Asiatic people have higher prevalence. Its pathogenesis remains controversial. Patients are young seek care because acute tender, cervical lymphadenopathy low-grade fever. Histologic findings include paracortical areas coagulative necrosis with...
Liver biopsy is essential in the follow-up of HCV-infected liver transplant recipients. The aim this study was to prospectively compare percutaneous (PLB) versus transjugular (TLB) assessment damage. We also explored diagnostic value hepatic venous pressure gradient (HVPG) identify patients at risk severe HCV disease recurrence after transplantation (LT). One hundred sixteen paired PLB and TLB (with HVPG measurement) were performed 3 or 12 months LT 80 patients. Concordance for...
Docosahexaenoic acid (DHA) is a omega-3 essential fatty that reduces the incidence and severity of number diseases. Recently, novel series DHA-derived lipid mediators with potent protective actions has been identified. In this study we demonstrate dietary amplification these products protects liver from necroinflammatory injury. vitro, supplementation hepatocytes DHA significantly reduced hydrogen peroxide-induced DNA damage, evaluated by "comet assay," oxidative stress, determined...
Alcoholic hepatitis (AH) is a severe condition developed in patients with underlying alcoholic liver disease. Ductular reaction has been associated chronic alcohol consumption but there no information regarding the extent of progenitor cell (LPC) proliferation AH. The aim this study was to investigate LPC markers AH and its correlation disease severity. Fifty-nine clinical histological diagnosis were included study. assessed by real-time polymerase chain (PCR) immunohistochemistry. Standard...
Following organ transplantation, lifelong immunosuppressive therapy is required to prevent the host immune system from destroying allograft. This can cause severe side effects and increased recipient morbidity mortality. Complete cessation of drugs has been successfully accomplished in selected transplant recipients, providing proof principle that operational allograft tolerance attainable clinical transplantation. The intra-graft molecular pathways associated with successful drug...
Idiopathic portal hypertension (IPH) is a rare cause of intrahepatic hypertension. Data on natural history and prognosis IPH are limited. We sought to describe the complications long-tem outcome by retrospectively studying 69 biopsy-proven cases IPH. Mean duration follow-up was 6.7 ± 4.6 years. All patients had evidence (PH) at diagnosis, 42% were symptomatic. Variceal bleeding (VB) most common manifestation. In those without 74% varices first endoscopy. with large varices, 1-year...
Significant liver fibrosis (F ≥ 2) and portal hypertension (hepatic venous pressure gradient [HVPG] 6 mmHg) at 1 year after transplantation (LT) identify patients with severe hepatitis C recurrence. We evaluated whether repeated stiffness measurements (LSM) following LT can discriminate between slow rapid “fibrosers” (fibrosis stage F2-F4 LT). Eighty-four who had undergone were infected virus (HCV) 19 controls not HCV underwent LSM 3, 6, 9, 12 months LT. All HCV-infected biopsy (paired HVPG...
A decade ago we proposed to enlist for transplantation those patients with resected hepatocellular carcinoma in whom pathology registered pejorative histological markers (microvascular invasion and/or satellites; ab initio indication) and not wait the appearance of recurrence. This study evaluates outcome this approach. From 1995 2012, 164 underwent resection. Eighty-five were potential candidates liver considered it upon detection markers. Patients without these followed, salvage was...
Abstract The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin human parenchymal tissue generation during embryonic development, homeostasis or repair. Here we report existence a hepatobiliary hybrid progenitor (HHyP) population in foetal using single-cell RNA sequencing. HHyPs are anatomically restricted to ductal plate maintain transcriptional profile distinct from hepatocytes, mature BECs. In addition,...
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C3 glomerulopathy (C3G) and primary immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) are rare diseases that share a similar pathogenesis; however, the prognostic significance of proteinuria reduction remains poorly characterized. This study compared outcomes in C3G IC-MPGN assessed impact changes on kidney prognosis. retrospective, longitudinal, multicenter used joint linear mixed-effects models to assess trajectories, Cox regression evaluate their association with...