A5101486510- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- T-cell and B-cell Immunology
- Pregnancy and Medication Impact
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- Iron Metabolism and Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Pancreatitis Pathology and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Inflammatory Bowel Disease
- Pharmacological Effects and Toxicity Studies
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- Hepatitis C virus research
- Systemic Lupus Erythematosus Research
- Ocular Disorders and Treatments
- Transplantation: Methods and Outcomes
- Ocular Diseases and Behçet’s Syndrome
- Reproductive System and Pregnancy
King's College Hospital
2016-2024
King's College London
2018-2024
University College London
2024
University of London
2024
Yahoo (United Kingdom)
2024
Barts Health NHS Trust
2023
Royal London Hospital
2023
Medical Research Council
2018-2022
Foundation for Liver Research
2017
University of Cambridge
2013
Regulatory T cells (Tregs) are a lymphocyte subset with intrinsic immunosuppressive properties that can be expanded in large numbers ex vivo and have been shown to prevent allograft rejection promote tolerance animal models. To investigate the safety, applicability, biological activity of autologous Treg adoptive transfer humans, we conducted an open-label, dose-escalation, Phase I clinical trial liver transplantation. Patients were enrolled while awaiting transplantation or 6-12 months...
CD4
Lim, Tiong Y.; Martinez‐Llordella, Marc; Kodela, Elisavet; Gray, Elisabeth; Heneghan, Michael A.; Sanchez‐Fueyo, Alberto , M.D., Ph.D. Author Information
Rates of pregnancy in women with cirrhosis are increasing. Risk hepatic decompensation during pregnancy, therefore, merits tailored obstetric and hepatology care. Prognostic markers that determine outcomes lacking.Medical records who attended clinic at King's College Hospital chronic liver disease (CLD) became pregnant from 1983 to 2017 were reviewed. Information on demographics, clinical history, serology, outcome was collected.In all, 165 pregnancies occurred 100 CLD including 80 48...
Liver transplantation (LT) is a successful treatment for both acute liver failure and end‐stage disease. The number of women reproductive age undergoing LT increasing. Pregnancy outcomes are favorable, but there still lack prognostic markers. We aimed to identify factors predictive adverse pregnancy in recipients. An analysis all pregnancies occurring recipients from 1989 2016 at King's College Hospital was performed. Clinical data 162 conceptions 93 were reviewed. Descriptive regression...
The use of herbal medications is increasing significantly in the UK and there a perception that preparations are without adverse effects. This case report highlights potential risks black cohosh, which one most commonly used products. 60-year-old Caucasian lady who presented with subacute liver failure secondary to taking cohosh. was further confirmed by biopsy she subsequently deteriorated underwent transplantation. Available evidence supports an association between cohosh risk...
Decompensated cirrhotic patients, compared with compensated exhibit a greater exaggerated inflammatory response to bacterial products orchestrated by interferons, IL-6, and IL-8. Postbacterial product stimulation levels of number pro-inflammatory cytokines negatively correlate liver disease severity biomarkers scores raising the possibility that switch an immunodeficient phenotype in cirrhosis-associated immune dysfunction may commence earlier course advanced disease.
Hypothermic oxygenated machine perfusion (HOPE) is an organ preservation strategy shown to reduce ischemia-reperfusion injury (IRI)-related complications following liver transplantation. In animal models, HOPE can also decrease alloimmune responses after transplantation, but this remains be evaluated in humans. Our study, involving 27 patients undergoing transplantation enrolled 2 randomized controlled trials comparing static cold storage with (14 HOPE-treated and 13 storage–treated), delves...
Background. The use of once-daily extended-release tacrolimus (ERT) is associated with improved long-term graft and patient survival when compared twice-daily (BDT), but the underlying reasons for differential are unclear. aim study was to compare clinical outcomes known impact on posttransplant de novo BDT ERT in liver transplantation (LT) recipients. Methods. We conducted a single-center, prospective sequential cohort analysis adult patients undergoing LT during change protocol from ERT,...
<h3>Introduction</h3> The British Society of Haematology (BSH) and European Association for the Study Liver (EASL) recommend screening first-degree relatives ('Cascade Screening') those diagnosed with haemochromatosis, as disease incidence is greater in affected compared general population.<sup>3 4</sup> Cascade enables early identification cases, timely management, improved patient outcomes. As a quality improvement initiative, we aimed to assess provision recommended cascade advice...