A5033612328- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis B Virus Studies
- Inflammatory Bowel Disease
- Gallbladder and Bile Duct Disorders
- Hepatitis C virus research
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Drug Transport and Resistance Mechanisms
- Hepatitis Viruses Studies and Epidemiology
- IgG4-Related and Inflammatory Diseases
- Global Health Workforce Issues
- Microscopic Colitis
- Genomics and Rare Diseases
- Hemoglobinopathies and Related Disorders
- COVID-19 Clinical Research Studies
- Adolescent and Pediatric Healthcare
- Iron Metabolism and Disorders
- Long-Term Effects of COVID-19
- Trace Elements in Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug-Induced Hepatotoxicity and Protection
King's College Hospital NHS Foundation Trust
2020-2025
King's College Hospital
2016-2025
King's College London
2020-2025
Royal Free London NHS Foundation Trust
2023
Princess Royal University Hospital
2017-2018
Lewisham and Greenwich NHS Trust
2018
Queen Elizabeth Hospital
2018
St George's Hospital
2016
University College London
2016
Creative Research Enterprises (United States)
2016
Abstract Background & Aims Evidence for the benefit of scheduled imaging early detection hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited. We aimed to compare different follow‐up strategies PSC with hypothesis that regular improves survival. Methods collected retrospective data from 2975 patients 27 centres. Patients were followed start or case clinical 1 January 2000, until death last alive. The endpoint was all‐cause mortality. Results A broad variety...
Variants in ATP8B1, ABCB11, and ABCB4 underlie the most prevalent forms of progressive familial intrahepatic cholestasis. We aim to describe variants these genes a cohort patients with adult-onset liver disease, explore genotype-phenotype correlation. Patients onset disease aged above 18 who underwent sequencing cholestasis for clinical purposes over 5-year period were identified. Bioinformatic analysis was performed. Liver histology evaluated variants. Of 356 tested, at least one variant...
Aims To reveal clinical, imaging and pathological features of ketamine cholangiopathy. Methods results Eight cases, who had a history long‐term use, abnormal liver function tests histological or radiological evidence cholangiopathy, were retrospectively reviewed. Cases consisted six men two women with median age 36 years. Ketamine was clinically prescribed in one case for pain control used recreationally the remaining seven 3–24 years (median = 12 years) until diagnosis Six cases prior...
The impact of chronic liver disease (CLD) in young people on lifestyle is poorly explored. One hundred four (20.51 years, male 44%), including 37% with autoimmune and 19% post-liver transplantation, completed an anonymous health questionnaire Thirty-nine per cent were considered overweight/obese. Female body mass index (BMI) was higher than BMI (26.5 vs. 23.4, p = 0.018), those taking steroids (n 38) more likely to be overweight/obese (66% 31%, 0.03). Half the cohort reported 'never' drink...
Although a good genotype-phenotype correlation has not been established in Wilson disease (WD), patients with loss-of-function (LOF) ATP7B variants demonstrate different clinical and biochemical characteristics. We aim to describe long-term treatment outcomes the chronic liver (CLD) phenotype evaluate an association LOF variants.This was single-center retrospective review of WD at least 1 variant ATP7B. Demographic, biochemical, genetic, parameters were obtained. The composite endpoint...
Warfarin-induced skin necrosis is a rare but serious complication of treatment with this commonly prescribed drug. This lesson presents the case patient extensive after inappropriately prolonged warfarinisation and delayed recognition. The condition briefly reviewed to highlight key features risk factors.
Abstract Purpose of Review Current treatments for chronic hepatitis B (CHB) are associated with low rates cure. Functional cure has been accepted as a viable treatment end point in CHB. There have substantial advances the field RNA interference (RNAi) therapeutics across wide range specialties, and clinical pipeline now encompasses This review will highlight some challenges therapeutic development, data RNAi CHB, future directions field. Recent Findings Early phase trials reported good...
Patients with autoimmune liver disease frequently fit diagnostic criteria for more than one condition. Up to 12.5% of hepatitis (AIH) and primary sclerosing cholangitis (PSC) cohorts have a label AIH/PSC overlap. There can be an interval many years between the diagnoses two conditions, sequence in which they are made is unpredictable. Issues exist use validated AIH patients no agreed diagnosis overlap, it based on combination biochemistry, autoantibody profile, cholangiogram, histology. A...
Summary Background Since azathioprine is associated with lymphoproliferative disorders in Epstein–Barr virus (EBV)‐naïve patients inflammatory bowel disease, guidelines advise avoidance. No recommendations exist for autoimmune liver disease (AILD). Aims To evaluate EBV status and EBV‐related complications paediatric AILD. Methods Single‐centre, retrospective, observational study of Results In 245 AILD, was used 168 (68.6%) mycophenolate mofetil 69 (28.2%). assessed 18 (10.7%) prior to 6...