A5012666865- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Pharmacogenetics and Drug Metabolism
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Drug Transport and Resistance Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Crystallization and Solubility Studies
- Pediatric Hepatobiliary Diseases and Treatments
- HIV/AIDS drug development and treatment
- Inflammatory mediators and NSAID effects
- X-ray Diffraction in Crystallography
- Alcohol Consumption and Health Effects
- Monoclonal and Polyclonal Antibodies Research
- Drug-Induced Adverse Reactions
- Poisoning and overdose treatments
- Diet, Metabolism, and Disease
- Chemotherapy-induced organ toxicity mitigation
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Ocular Toxicity
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Pancreatitis Pathology and Treatment
Hospital de Clínicas
2016-2025
Universidad de la República
2015-2025
Pennsylvania State University
2025
Universidad de Montevideo
2014-2023
Instituto de Instrumentación para Imagen Molecular
2023
Newcastle University
2013
Hospital Universitario Doctor Peset
2013
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2013
Hôpital Intercommunal de Créteil
2013
Freeman Hospital
2013
Background & AimsWe performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported factors.MethodsWe GWAS of 862 persons with DILI and 10,588 population-matched controls. The first set cases was recruited before May 2009 in Europe (n = 137) the United States 274). second were identified through 2013 international collaborative studies Europe, States, South America. For GWAS, we included...
Academic dropout is a common occurrence in higher education (i.e. students leaving their academic program before completing degree). In addition to academic, social, financial, and other factors, psychological symptoms among college may also contribute dropout. First-year, full-time (N = 573) completed multidimensional self-report measure of provided demographic information during first week classes. Their enrollment graduation data were then collected by the university following 6 years....
Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chronic disease, affecting 20-30% of general population. Furthermore, its prevalence predicted to increase exponentially in next decades, concomitantly with global obesity, type 2 diabetes mellitus (T2DM), and sedentary lifestyle. a clinical syndrome that encompasses wide spectrum associated diseases hepatic complications such as hepatocellular carcinoma (HCC)....
Data from Europe and North America have been published regarding the risk of developing hepatocellular carcinoma (HCC) after treatment with direct antiviral agents (DAA). We proposed to evaluate cumulative incidence associated factors for de novo HCC.This was a prospective multicentre cohort study Latin including 1400 F1-F4-treated patients DAAs (F3-F4 n = 1017). Cox proportional regression models (hazard ratios, HR 95% CI) were used independent variables HCC. Further adjustment competing...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Most studies addressing epidemiology HCC originate from developed countries. This study reports preliminary findings a multinational approach to characterize in South America.We evaluated 1336 patients seen at 14 centres six American countries using retrospective design with participating completing template chart patient characteristics. The diagnosis was made radiographically or histologically for...
Background and Aims Alcohol‐associated liver disease (ALD) is the leading cause of liver‐related mortality in Latin America, yet impact public health policies (PHP) on unknown. We aimed to assess association between alcohol PHP deaths due ALD American countries. Approach Results performed an ecological multinational study including 20 countries America (628,466,088 inhabitants). obtained country‐level sociodemographic information from World Bank Open Data source. Alcohol‐related data for...
Abstract Background & Aims Cyproterone acetate ( CPA ), an anti‐androgenic drug for prostate cancer, has been associated with drug‐induced liver injury DILI ). We aim to expand the knowledge on spectrum of phenotypes and outcomes ‐induced . Methods Twenty‐two males (70 ± 8 years; range 54–83) developing damage as a result therapy (dose: 150 50 mg/day; 50–200) were included. Severity index causality by RUCAM assessed. Results From 1993 2013, 22 patients retrieved. Latency was 163 97 days....
Idiosyncratic drug-induced liver injury (DILI) caused by xenobiotics (drugs, herbals and dietary supplements) is an uncommon cause of disease presenting with a wide range phenotypes severity, acute hepatitis mimicking viral to autoimmune hepatitis, steatosis, fibrosis or rare chronic vascular syndromes. Disease severity ranges from asymptomatic test abnormalities failure. DILI has been traditionally classified in predictable intrinsic (dose-related) unpredictable (not dose-related)...
Abstract Background & aims Idiosyncratic drug‐induced liver injury (DILI) with autoimmune features is a condition laboratory and histological characteristics similar to those of idiopathic hepatitis (AIH), which despite being increasingly reported, remains largely undefined. We aimed describe in‐depth the this entity in large series patients from two prospective DILI registries. Methods cases collected Spanish Registry Latin American Network were compared without an independent cohort...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the leading causes chronic globally. Based on 2023 definition, MASLD characterized by presence metabolic dysfunction and limited alcohol consumption (<140 grams/week for women, <210 men). Given significant burden in Latin America, this guidance was developed American Association Study Liver (ALEH) Working Group to address key aspects its clinical assessment therapeutic strategies. In ultrasonography recommended as...
No prospective study has been published investigating etiology of HCC in Latin America. The primary aim this was to analyze the liver disease patients with from our area. Secondary aims were evaluate staging using Okuda and BCLC classifications; percentage receiving treatment.The Governing Board American Association for Study Liver designed protocol. During a 18 month period, all members invited load their incident cases on line.240 9 countries uploaded, 174 male (72.5%), median age 64...
Early reports accounted for two main genotypes of Piscirickettsia salmonis, a fish pathogen and causative agent piscirickettsiosis, placing the single isolate EM-90 apart from prototypic LF-89 related isolates. In this study, we provide evidence that, contrary to what has been supposed, EM-90-like isolates are highly prevalent disseminated across Chilean marine farms. Molecular analysis 507 P. salmonis field derived rearing areas, diverse hosts collected over 6 years, revealed that nearly...
Introduction. Drug-induced liver injury (DILI) remains a major problem for drug development and represents challenging diagnosis clinicians. The absence of specific biomarkers diagnosing DILI precludes the availability reliable data on epidemiology disease. In this study we aimed to describe features idiosyncratic hepatotoxicity reports in Latin American countries. Material methods. A literature search was performed using online version MEDLINE, EMBASE, Scopus, Google Scholar bases from...
Nitrofurantoin is a synthetic antibiotic that recommended as first-choice treatment for uncomplicated urinary tract infections. The prescription of this drug has increased dramatically, especially in Latin American countries. We described the demographics, clinical characteristics, biochemical features, and outcome nitrofurantoin-induced liver injury. analyzed 23 cases from DILI Network (LATINDILI) Spanish Registry. Causality was assessed with RUCAM RECAM scale. Of included our series, 96%...