A5041318057- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Health disparities and outcomes
- Cardiovascular Disease and Adiposity
- Global Public Health Policies and Epidemiology
- Substance Abuse Treatment and Outcomes
- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Hepatitis C virus research
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Advanced Glycation End Products research
- Diet and metabolism studies
- Heart Failure Treatment and Management
- Obesity, Physical Activity, Diet
- Food Security and Health in Diverse Populations
- Hepatocellular Carcinoma Treatment and Prognosis
- Diabetes Treatment and Management
- Diabetes Management and Research
- Hepatitis B Virus Studies
Drexel University
2020-2025
Johns Hopkins University
2015-2024
Johns Hopkins Medicine
2015-2024
Philadelphia Department of Public Health
2021-2023
Universidade Federal do Rio Grande
2023
Prefeitura Municipal de Belo Horizonte
2023
Welch Foundation
2013-2021
Universidad Mariana
2012-2019
Johns Hopkins Hospital
2015-2018
Bloomberg (United States)
2012-2018
Depressive symptoms are associated with development of type 2 diabetes, but it is unclear whether diabetes a risk factor for elevated depressive symptoms.To examine the bidirectional association between and diabetes.Multi-Ethnic Study Atherosclerosis, longitudinal, ethnically diverse cohort study US men women aged 45 to 84 years enrolled in 2000-2002 followed up until 2004-2005.Elevated defined by Center Epidemiologic Studies Depression Scale (CES-D) score 16 or higher, use antidepressant...
Previous estimates of the prevalence nonalcoholic fatty liver disease (NAFLD) in US population relied on measures enzymes, potentially underestimating burden this disease. We used ultrasonography data from 12,454 adults who participated Third National Health and Nutrition Examination Survey, conducted United States 1988 to 1994. defined NAFLD as presence hepatic steatosis absence elevated alcohol consumption. In population, rates were 21.4% 19.0%, respectively, corresponding 32.5 (95%...
The prognoses with respect to mortality and hepatic nonhepatic outcomes across the histologic spectrum of nonalcoholic fatty liver disease (NAFLD) are not well defined.
The benzopyranopyrrole S33084 displayed pronounced affinity (p<i>K</i><sub>i</sub> = 9.6) for cloned human hD<sub>3</sub>-receptors, and >100-fold lower hD<sub>2</sub> all other receptors (>30) examined. concentration dependently, potently, competitively (pA<sub>2</sub> 9.7) antagonized dopamine (DA)-induced [<sup>35</sup>S]guanosine-5′-<i>O</i>-(3-thio)triphosphate (GTPγS) binding at hD<sub>3</sub>-receptors. It also dependently abolished stimulation by DA of...
OBJECTIVE Weight loss through lifestyle changes is recommended for nonalcoholic fatty liver disease (NAFLD). However, its efficacy in patients with type 2 diabetes unproven. RESEARCH DESIGN AND METHODS Look AHEAD (Action Health Diabetes) a 16-center clinical trial 5,145 overweight or obese adults diabetes, who were randomly assigned to an intensive intervention (ILI) induce minimum weight of 7% control group received support and education (DSE). In the Fatty Liver Ancillary Study, 96...
Obesity is a risk factor for various subtypes of cardiovascular disease (CVD), including coronary heart (CHD), failure (HF), and stroke. Nevertheless, there are limited comparisons the associations obesity with each these CVD subtypes, particularly regarding extent to which they unexplained by traditional mediators. We followed 13 730 participants in Atherosclerosis Risk Communities (ARIC) study who had body mass index ≥18.5 no at baseline (visit 1, 1987-1989). compared association higher...
Background— Persons with prediabetes and diabetes mellitus are at high risk for cardiovascular events. However, the relationships of to development subclinical myocardial damage unclear. Methods Results— We measured cardiac troponin T a highly sensitive assay (hs-cTnT) 2 time points, 6 years apart, among 9051 participants community-based Atherosclerosis Risk in Communities Study no mellitus, or prediabetes, without disease including silent infarction by ECG. First, we examined incidence...
The risk of nonalcoholic fatty liver disease (NAFLD) among obese individuals without obesity-related metabolic abnormalities, a condition referred to as metabolically healthy (MHO), is largely unexplored. Therefore, we examined the association between body mass index (BMI) categories and development NAFLD in large cohort men women.A study was conducted 77,425 women free abnormalities at baseline, who were followed-up annually or biennially for an average 4.5 years. Being defined not having...
The long-term impact of alcohol-related public health policies (PHPs) on disease burden is unclear. We aimed to assess the association between PHPs and consequences.
Fructose consumption predicts increased hepatic fibrosis in those with nonalcoholic fatty liver disease (NAFLD). Because of its ability to lower adenosine triphosphate (ATP) levels, habitual fructose could result more ATP depletion and impaired recovery. The degree after an intravenous (IV) challenge test low- versus high-fructose consumers was assessed. We evaluated diabetic adults enrolled the Action for Health Diabetes Fatty Liver Ancillary Study (n = 244) whom dietary estimated by a...
We hypothesized that nonalcoholic fatty liver disease (NAFLD) is independently associated with cognitive impairment in a representative sample of the general US population regardless presence cardiovascular (CVD) or its risk factors.This was cross-sectional study 4,472 adults aged 20-59 years who participated Third National Health and Nutritional Examination Survey. The participants underwent assessment enzyme activity hepatic steatosis by ultrasound, evaluation using following...
Cuba's economic crisis of 1989–2000 resulted in reduced energy intake, increased physical activity, and sustained population-wide weight loss. The authors evaluated the possible association these factors with mortality trends. Data on per capita daily loss, smoking were systematically retrieved from national local surveys. National vital statistics 1980–2005 used to assess trends diabetes, coronary heart disease, stroke, cancer, all causes. intake 2,899 calories 1,863 calories. During...
Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, was associated with subclinical atherosclerosis in many cross-sectional studies, but prospective association between NAFLD and progression has not been evaluated. This study conducted to evaluate coronary atherosclerosis.This retrospective cohort included 4731 adult men women no history cardiovascular (CVD), or cancer at baseline who participated repeated regular health screening examination 2004...
To characterize the prevalence of nonalcoholic fatty liver disease (NAFLD) by race in a nationally representative sample U.S. population and to investigate potential explanatory factors for racial disparities.Cross-sectional study 4,037 non-Hispanic white, 2,746 black, 2,892 Mexican-American adults Third National Health Nutrition Examination Survey. NAFLD was defined using ultrasound with elevated aminotransferases.Age-adjusted highest Mexican-Americans (21.2%), followed whites (12.5%),...
The benefits of physical activity are well documented, but scalable programs to promote needed. Interventions that assign tailored and dynamically adjusting goals could effect significant increases in have not yet been implemented at scale.Our aim was examine the effectiveness an open access, Internet-based walking program assigns daily step each participant.A two-arm, pragmatic randomized controlled trial compared intervention no treatment. Participants were recruited from a workplace...