A5078574182- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Menopause: Health Impacts and Treatments
- Cardiac Health and Mental Health
- Lipoproteins and Cardiovascular Health
- Diet, Metabolism, and Disease
- Physical Activity and Health
- Adipose Tissue and Metabolism
- Ovarian function and disorders
- Health disparities and outcomes
- Health, Environment, Cognitive Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular and exercise physiology
- Epigenetics and DNA Methylation
University of Minnesota
2016-2025
Minnesota Department of Health
2014-2025
University of Minnesota System
2007-2025
Twin Cities Orthopedics
2008-2022
The University of Texas Health Science Center at Houston
2010-2020
Johns Hopkins University
2005-2020
National Institutes of Health
2017
Northwestern University
2007-2017
Kaiser Permanente
2007-2017
University of Michigan
2005-2017
Depressive symptoms are associated with development of type 2 diabetes, but it is unclear whether diabetes a risk factor for elevated depressive symptoms.To examine the bidirectional association between and diabetes.Multi-Ethnic Study Atherosclerosis, longitudinal, ethnically diverse cohort study US men women aged 45 to 84 years enrolled in 2000-2002 followed up until 2004-2005.Elevated defined by Center Epidemiologic Studies Depression Scale (CES-D) score 16 or higher, use antidepressant...
To determine whether type 2 diabetes is associated with fracture in older women, we analyzed data from 9654 age 65 yr or older, the Study of Osteoporotic Fractures. Diabetes at onset 40 was reported by 657 whom 106 used insulin. A total 2624 women experienced least one nonvertebral during an average follow-up 9.4 yr, and 388 had vertebral interval 3.7 yr. Although higher bone mineral density, it also a risk specific fractures. Compared nondiabetics, who were not using insulin increased hip...
OBJECTIVE—To determine whether older women with diabetes have an increased risk of falls and known factors for account any risk. RESEARCH DESIGN AND METHODS—This prospective cohort study included 9,249 ≥67 years age enrolled in the Study Osteoporotic Fractures. Diabetes was determined by questionnaire at baseline. Physical performance measured second examination. Subsequently, were ascertained every 4 months postcard. RESULTS—A total 629 (6.8%) had diabetes, including 99 who used insulin....
The prevalence of obesity increased in the United States through 1980s. authors examined 10-year aging and secular (time-related) trends Coronary Artery Risk Development Young Adults (CARDIA) cohort for indications whether these are continuing ages peak weight gain young adults. CARDIA is a population-based, prospective study 5, 115 African-American White men women aged 18–30 years at baseline. Body overweight were measured five time points from 1985–1986 to 1995–1996. Linear, mixed-model...
<h3>Objective</h3> To assess coronary artery calcium (CAC) score and subsequent risk for heart disease (CHD) cardiovascular (CVD) events among asymptomatic women judged to be at low by the Framingham (FRS), a common approach determining 10-year absolute CHD. Based on population survey data, 95% of American are considered based FRS. <h3>Methods</h3> The Multi-Ethnic Study Atherosclerosis (MESA) included 3601 aged 45 84 years baseline. CAC was measured computed tomography. Cox proportional...
Coronary artery calcium (CAC) is associated with coronary heart disease (CHD) and cardiovascular (CVD); however, prognostic data on CAC are limited in younger adults.To determine if adults aged 32 to 46 years incident clinical CHD, CVD, all-cause mortality during 12.5 of follow-up.The Artery Risk Development Young Adults (CARDIA) Study a prospective community-based study that recruited 5115 black white participants 18 30 from March 25, 1985, June 7, 1986. The cohort has been under...
Objective Cardiovascular disease is the number one killer of women. Identifying women at risk cardiovascular has tremendous public health importance. Early menopause associated with increased events in some predominantly white populations, but not consistently. Our objective was to determine if self-reported early (menopause an age <46 y) identifies as for future coronary heart or stroke. Methods The study population came from Multi-Ethnic Study Atherosclerosis, a longitudinal, ethnically...
Data supporting physical activity guidelines to prevent long-term weight gain are sparse, particularly during the period when highest risk of occurs.To evaluate relationship between habitual levels and changes in body mass index (BMI) waist circumference over 20 years.The Coronary Artery Risk Development Young Adults (CARDIA) study is a prospective longitudinal with years follow-up, 1985-1986 2005-2006. Habitual was defined as maintaining high, moderate, low based on sex-specific tertiles...
Steps per day is a meaningful metric for physical activity promotion in clinical and population settings. To guide strategies of step goals, it important to understand the association steps with end points, including mortality.To estimate premature (age 41-65 years) all-cause mortality among Black White men women.This prospective cohort study was part Coronary Artery Risk Development Young Adults (CARDIA) study. Participants were aged 38 50 years wore an accelerometer from 2005 2006....
Objectives: To identify independent risk factors for first hip fracture over 10 years of follow‐up. Design: Prospective cohort study. Setting: Four U.S. clinical centers. Participants: A total 6,787 women aged 66 and older in the Study Osteoporotic Fractures. Measurements: Total bone mineral density (BMD) using dual‐energy x‐ray absorptiometry a comprehensive set potential were collected. Incident fractures identified prospectively confirmed radiographic report. Results: Six hundred two...
The prevalence of type 2 diabetes among Hispanic and Asian Americans is increasing. These groups are largely comprised immigrants who may be undergoing behavioral lifestyle changes associated with development diabetes. We studied the association between acculturation in a population sample 708 Mexican-origin Hispanics, 547 non-Mexican-origin 737 Chinese participants Multi-Ethnic Study Atherosclerosis (MESA).Diabetes was defined as fasting glucose >/=126 mg/dl and/or use antidiabetic...
This article examined the prevalence of binge eating disorder (BED), obesity, and depressive symptomatology in a biracial, population-based cohort men women participating longitudinal study cardiovascular risk factor development. The Revised Questionnaire on Eating Weight Patterns was used to establish BED status among 3,948 (55% women, 48% Black) participants (age 28–40 years). Body mass index (BMI: kg/m2) define overweight (BMI>-27.3 ≥27.8 men). Depressive assessed with Center for...
Background— The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings incompletely characterized. To identify novel variants influencing burden, we conducted a meta-analysis multiethnic genome-wide association studies. Methods Results— We included 21 079 middle-aged to elderly individuals from 29 population-based cohorts, who were free dementia stroke European (n=17...
Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) distribution among those predominantly African ancestry (AA). We performed GWAS WC and WHR, adjusted unadjusted for BMI, in up to 33,591 27,350 AA individuals, respectively. identified loci associated with individuals using meta-analyses GWA...
Fitness and physical activity are each inversely associated with the development of hypertension. We tested whether fitness were independently 20-year incidence hypertension in 4618 men women. Hypertension was determined participants who had systolic blood pressure ≥140 mm Hg or diastolic ≥90 reported antihypertensive medication use. estimated based on duration a symptom-limited graded exercise treadmill test, self-reported. The rate 13.8 per 1000 person-years (n=1022). Both baseline (hazard...