Laura J. Rasmussen‐Torvik
A5048459234- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Rare Diseases
- Nutrition, Genetics, and Disease
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Heart Failure Treatment and Management
- Bioinformatics and Genomic Networks
- Cardiovascular Disease and Adiposity
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Biomedical Text Mining and Ontologies
- Cancer-related molecular mechanisms research
- Bariatric Surgery and Outcomes
- Lipoproteins and Cardiovascular Health
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
Northwestern University
2016-2025
Beth Israel Deaconess Medical Center
2021
Icahn School of Medicine at Mount Sinai
2020
Northwestern Medicine
2014-2017
K.A. Rasmussen (Norway)
2012-2016
General Department of Preventive Medicine
2015
University of Washington Medical Center
2014
University of Minnesota
2005-2013
Minnesota Department of Health
2007-2013
University of Oklahoma Health Sciences Center
2013
Background— Left atrial (LA) enlargement is associated with adverse events in heart failure preserved ejection fraction (HFpEF). However, the role of LA mechanics (ie, strain measures) HFpEF has not been well studied. We hypothesized that HFpEF, reduced (worse) a key pathophysiologic abnormality and stronger correlate than left ventricular or right longitudinal strain. Methods Results— evaluated baseline function 308 patients who were followed up longitudinally for outcomes. All underwent...
Genome-wide association studies (GWAS) require high specificity and large numbers of subjects to identify genotype-phenotype correlations accurately. The aim this study was type 2 diabetes (T2D) cases controls for a GWAS, using data captured through routine clinical care across five institutions different electronic medical record (EMR) systems.An algorithm developed T2D based on combination diagnoses, medications, laboratory results. performance the validated at three participating compared...
The American Heart Association (AHA) has defined the concept of ideal cardiovascular health in promotion 2020 Strategic Impact Goals. We examined whether adherence to levels 7 AHA metrics was associated with incident cancers Atherosclerosis Risk In Communities (ARIC) study over 17 19 years follow-up.After exclusions for missing data and prevalent cancer, 13 253 ARIC participants were included analysis. Baseline measurements used classify according metrics. Combined cancer incidence...
We describe here the design and initial implementation of eMERGE-PGx project. eMERGE-PGx, a partnership Electronic Medical Records Genomics Network Pharmacogenomics Research Network, has three objectives: (i) to deploy PGRNseq, next-generation sequencing platform assessing sequence variation in 84 proposed pharmacogenes, nearly 9,000 patients likely be prescribed drugs interest 1- 3-year time frame across several clinical sites; (ii) integrate well-established clinically validated...
<h3>Importance</h3> Bariatric surgery is an effective and safe approach for weight loss short-term improvement in metabolic disorders such as diabetes. However, studies have been limited most settings by lack of a nonsurgical group, losses to follow-up, missing data, small sample sizes clinical trials observational studies. <h3>Objective</h3> To assess the association 3 common types bariatric compared with treatment mortality other outcomes among obese patients. <h3>Design, Setting,...
Abstract Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these by analysis variants HumanExome BeadChip in 60,564 non-diabetic individuals 16,491 T2D cases 81,877 controls. We identify a novel association low-frequency nonsynonymous SNV GLP1R (A316T; rs10305492; MAF=1.4%) with lower FG ( β =−0.09±0.01 mmol l −1 , P =3.4 × 10 −12 ), risk (OR[95%CI]=0.86[0.76–0.96], =0.010), early secretion (β =−0.07±0.035 pmol =0.048),...
Abstract Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in leptin ( LEP ) gene are well known to cause deficiency and severe obesity, no common loci regulating have been uncovered. Therefore, we performed a genome-wide association study (GWAS) from 32,161 individuals followed up reaching P <10 −6 19,979 additional individuals. We identify five robustly associated <5 × 10 −8 in/near , SLC32A1...
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and environmental risk factors that disproportionately afflicts communities of color. Leveraging existing large-scale genome-wide association studies (GWAS), polygenic scores (PRS) have shown promise to complement established clinical intervention paradigms, improve early diagnosis prevention T2D. However, date, T2D PRS been most widely developed validated in individuals European descent. Comprehensive...
Genetic discoveries are validated through the meta-analysis of genome-wide association scans in large international consortia. Because environmental variables may interact with genetic factors, investigation differing effects for distinct levels an exposure these consortia yield additional susceptibility loci undetected by main analysis. We describe a method joint (JMA) SNP and Environment (SNP × E) regression coefficients use gene-environment interaction studies.
<h3>Importance</h3> Large-scale DNA sequencing identifies incidental rare variants in established Mendelian disease genes, but the frequency of related clinical phenotypes unselected patient populations is not well established. Phenotype data from electronic medical records (EMRs) may provide a resource to assess relevance variants. <h3>Objective</h3> To determine EMRs for individuals with designated as pathogenic by expert review arrhythmia susceptibility genes. <h3>Design, Setting, and...
Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) distribution among those predominantly African ancestry (AA). We performed GWAS WC and WHR, adjusted unadjusted for BMI, in up to 33,591 27,350 AA individuals, respectively. identified loci associated with individuals using meta-analyses GWA...
Genome-wide association studies (GWAS) may have reached their limit of detecting common type 2 diabetes (T2D)–associated genetic variation. We evaluated the performance current polygenic T2D prediction. Using data from Framingham Offspring (FOS) and Coronary Artery Risk Development in Young Adults (CARDIA) studies, we tested three hypotheses: 1) a 62-locus genotype risk score (GRSt) improves prediction compared with previous less inclusive GRSt; 2) separate GRS for β-cell (GRSβ) insulin...