Lisa W. Martin
A5041866033- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Menopause: Health Impacts and Treatments
- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- Estrogen and related hormone effects
- Genomics and Rare Diseases
- Lipoproteins and Cardiovascular Health
- Vitamin D Research Studies
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- Atrial Fibrillation Management and Outcomes
- Cardiac Health and Mental Health
- RNA modifications and cancer
- Heart Failure Treatment and Management
- Bioinformatics and Genomic Networks
- Lipid metabolism and disorders
- Physical Activity and Health
- Acute Myocardial Infarction Research
- Obesity, Physical Activity, Diet
- Cancer survivorship and care
- Cardiovascular Function and Risk Factors
- Cancer, Lipids, and Metabolism
- Blood Pressure and Hypertension Studies
- Cholesterol and Lipid Metabolism
George Washington University
2016-2025
Cincinnati Children's Hospital Medical Center
2013-2025
Northwestern University
2011-2024
University of Washington
2012-2024
Princeton University
1998-2023
Cambridge University Press
2023
Seattle University
2022
Beth Israel Deaconess Medical Center
2021
Nationwide Children's Hospital
2021
University of the Sunshine Coast
2021
Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention.To report a comprehensive, integrated overview of findings from the 2 Women's Health Initiative (WHI) trials with extended postintervention follow-up.A total 27,347 postmenopausal women aged 50 to 79 years were enrolled at 40 US centers.Women an intact uterus received conjugated equine estrogens (CEE; 0.625 mg/d) plus medroxyprogesterone acetate (MPA; 2.5...
Tamoxifen and raloxifene have limited patient acceptance for primary prevention of breast cancer. Aromatase inhibitors prevent more contralateral cancers cause fewer side effects than tamoxifen in patients with early-stage cancer.In a randomized, placebo-controlled, double-blind trial exemestane designed to detect 65% relative reduction invasive cancer, eligible postmenopausal women 35 years age or older had at least one the following risk factors: 60 older; Gail 5-year score greater 1.66%...
The Women's Health Initiative Estrogen-Alone Trial was stopped early after a mean of 7.1 years follow-up because an increased risk stroke and little likelihood altering the balance to benefit by planned trial termination date. Postintervention health outcomes have not been reported.
Health outcomes from the Women's Initiative Estrogen Plus Progestin and Estrogen-Alone Trials have been reported, but previous publications generally not focused on all-cause cause-specific mortality.
By contrast with many observational studies, women in the Women's Health Initiative (WHI) trial who were randomly allocated to receive oestrogen alone had a lower incidence of invasive breast cancer than did those received placebo. We aimed assess influence use on longer term and mortality extended follow-up this cohort.Between 1993 1998, WHI enrolled 10,739 postmenopausal from 40 US clinical centres into randomised, double-masked, placebo-controlled trial. Women aged 50-79 years undergone...
Although studies have shown that physically active breast cancer survivors lower all-cause mortality, the association between change in physical activity from before to after diagnosis and mortality is not clear. We examined associations among pre- postdiagnosis activity, cancer-specific postmenopausal women. A longitudinal study of 4,643 women diagnosed with invasive entry into Women's Health Initiative Physical recreation walking was determined at baseline (prediagnosis) (assessed 3 or 6...
Framingham-based and Reynolds Risk scores for cardiovascular disease (CVD) prediction have not been directly compared in an independent validation cohort. We selected a case-cohort sample of the multiethnic Women's Health Initiative Observational Cohort, comprising 1722 cases major CVD (752 myocardial infarctions, 754 ischemic strokes, 216 other deaths) random subcohort 1994 women without prior CVD. estimated risk using Adult Treatment Panel III (ATP-III) score, Score, Framingham model,...
Heart failure is an important and growing public health problem in women. Risk factors for incident hospitalized heart with preserved ejection fraction (HFpEF) compared reduced (HFrEF) women differences by race/ethnicity are not well characterized.
Current dietary recommendations for patients with heart failure (HF) are largely based on data from non-HF populations; evidence associations of patterns outcomes in HF is limited. We therefore evaluated Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diet scores mortality among postmenopausal women HF. Women's Health Initiative participants were followed up the date hospitalization through death or last participant contact before August 2009. DASH calculated food-frequency...
<h3>Background</h3> Elective bilateral salpingo-oophorectomy (BSO) is routinely performed with hysterectomy for benign conditions despite conflicting data on long-term outcomes. <h3>Methods</h3> This a prospective cohort of 25 448 postmenopausal women aged 50 to 79 years enrolled in the Women's Health Initiative Observational Study who had history and BSO (n = 14 254 [56.0%]) or ovarian conservation 11 194 [44.0%]) no family cancer. Multivariable Cox proportional hazards regression models...
Hypertension is a leading cause of global disease, mortality, and disability. While individuals African descent suffer disproportionate burden hypertension its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure people ancestry, we performed both single multiple-trait genome-wide association analyses. We analyzed 21 studies comprised 31,968 validated our results with additional 54,395 from multi-ethnic These analyses...
Atrial fibrillation (AF) is the most common cardiac arrhythmia and associated with increased risk of stroke death. Obesity an independent factor for AF, but modifiers this are not well known. We studied roles obesity, physical activity, their interaction in conferring incident AF. The Women's Health Initiative (WHI) Observational Study was a prospective observational study 93 676 postmenopausal women followed average 11.5 years. Incident AF identified using WHI-ascertained hospitalization...
Investigating genetic architecture of complex traits in ancestrally diverse populations is imperative to understand the etiology disease. However, current paucity research people African and Latin American ancestry, Hispanic indigenous peoples United States likely exacerbate existing health disparities for many common diseases. The Population Architecture using Genomics Epidemiology, Phase II (PAGE II), Study was initiated 2013 by National Human Genome Research Institute expand our...