A5085936676- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Genomic variations and chromosomal abnormalities
- BRCA gene mutations in cancer
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Genetic and phenotypic traits in livestock
- Nutrition, Genetics, and Disease
- Genetic Neurodegenerative Diseases
- Forensic and Genetic Research
- Race, Genetics, and Society
- Multiple Sclerosis Research Studies
- Bipolar Disorder and Treatment
- Autism Spectrum Disorder Research
- Prostate Cancer Treatment and Research
- Hereditary Neurological Disorders
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Molecular Biology Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Chromosomal and Genetic Variations
- Asthma and respiratory diseases
Kaiser Permanente
2016-2025
University of California, San Francisco
2016-2025
Paderborn University
2024
University of California, Davis
2010-2023
UCSF Helen Diller Family Comprehensive Cancer Center
2020-2023
Center for Human Genetics
2005-2020
Kaiser Permanente Oakland Medical Center
2003-2019
California Center for Sleep Disorders
2018
Stanford University
1998-2015
Yale University
1988-2015
The identification of the genetic basis complex human diseases such as schizophrenia and diabetes has proven difficult. In their Perspective, Risch Merikangas propose that we can best accomplish this goal by combining power genome project with association studies, a method for determining disease.
A family history of premature coronary heart disease has long been thought to be a risk factor for disease. Using data from 26 years follow-up 21,004 Swedish twins born between 1886 and 1925, we investigated this issue further by assessing the death in pairs monozygotic dizygotic twins.
A debate has recently arisen over the use of racial classification in medicine and biomedical research. In particular, with completion a rough draft human genome, some have suggested that may not be useful for studies, since it reflects "a fairly small number genes describe appearance"1 "there is no basis genetic code race."2 part on these conclusions, argued exclusion ethnic from research.3 United States, race background been used as cause .
Linkage mapping generally localizes disease genes to 1- 2-cM regions of chromosomes. In theory, further refinement location can be achieved by population-based studies linkage disequilibrium between locus alleles and at adjacent markers. One approach localization, dubbed simple mapping, is determine the relative plotting values against marker locations. We investigate properties five measures, correlation coefficient Δ, Lewontin'sD′, robust formulation population attributable risk δ,...
Background. Improvements in screening techniques have made significant contributions to the early detection of breast cancer. Physicians thus face task providing appropriate schedules for their patients. One group whom this is particularly important are those women with a family history Methods. In report, data from Cancer and Steroid Hormone Study, population-based, case-control study conducted by Centers Disease Control, used provide age-specific risk estimates cancer The set includes 4730...
The ability to taste the substance phenylthiocarbamide (PTC) has been widely used for genetic and anthropological studies, but studies have produced conflicting results demonstrated complex inheritance this trait. We identified a small region on chromosome 7q that shows strong linkage disequilibrium between single-nucleotide polymorphism (SNP) markers PTC sensitivity in unrelated subjects. This contains single gene encodes member of TAS2R bitter receptor family. three coding SNPs giving rise...
BACKGROUND The age-specific proportion of breast and ovarian cancer in the general population that is likely to be due a breast/ovarian susceptibility gene(s) estimated. In addition, penetrance for women predicted carriers gene calculated using population-based data. METHODS Data are from Cancer Steroid Hormone Study, population-based, case–control study conducted by Centers Disease Control, which includes 4730 cases aged 20 54 years. Information regarding occurrence was collected mothers...
The genome of an admixed individual represents a mixture alleles from different ancestries. In the United States, two largest minority groups, African-Americans and Hispanics, are both admixed. An understanding admixture proportion at level (individual admixture, or IA) is valuable for population geneticists epidemiologists who conduct case-control association studies in these groups. Here we present extension previously described frequentist (maximum likelihood ML) approach to estimate that...