A5101626650- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- BRCA gene mutations in cancer
- Radiomics and Machine Learning in Medical Imaging
- Bioinformatics and Genomic Networks
- Pituitary Gland Disorders and Treatments
- Epigenetics and DNA Methylation
- Global Cancer Incidence and Screening
- MicroRNA in disease regulation
- Head and Neck Surgical Oncology
- Ferroptosis and cancer prognosis
- Neurofibromatosis and Schwannoma Cases
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- Lung Cancer Research Studies
- Chromatin Remodeling and Cancer
- Genetic Associations and Epidemiology
- Gene expression and cancer classification
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
Brigham and Women's Hospital
2015-2025
Yale University
2015-2024
Dana-Farber Cancer Institute
2014-2024
Harvard University
2011-2024
Great Ormond Street Hospital
2024
University College London
2024
SickKids Foundation
2024
Hospital for Sick Children
2024
University of Findlay
2022
University of New Haven
2017-2019
Since falling is associated with serious morbidity among elderly people, we investigated whether the risk of could be reduced by modifying known factors.
Background. Improvements in screening techniques have made significant contributions to the early detection of breast cancer. Physicians thus face task providing appropriate schedules for their patients. One group whom this is particularly important are those women with a family history Methods. In report, data from Cancer and Steroid Hormone Study, population-based, case-control study conducted by Centers Disease Control, used provide age-specific risk estimates cancer The set includes 4730...
BACKGROUND: Serious fall injury represents a little studied, yet common and potentially preventable, cause of morbidity mortality among older persons. We determined the frequency of, risk factors for, experiencing serious events persons in community. SUBJECTS: A representative sample 1103 community‐living aged 72 years underwent comprehensive baseline 1‐year evaluations. MAIN OUTCOME MEASURES: During median 31 months follow‐up, data were obtained using calendars. Injury from telephone...
BACKGROUND The age-specific proportion of breast and ovarian cancer in the general population that is likely to be due a breast/ovarian susceptibility gene(s) estimated. In addition, penetrance for women predicted carriers gene calculated using population-based data. METHODS Data are from Cancer Steroid Hormone Study, population-based, case–control study conducted by Centers Disease Control, which includes 4730 cases aged 20 54 years. Information regarding occurrence was collected mothers...
Abstract BACKGROUND. The purpose of the current study was to characterize outcomes patients with metastatic triple‐negative breast cancers, including risk and clinical consequences central nervous system (CNS) recurrence. METHODS. Using pharmacy pathology records, a group 116 who were treated for cancer at Dana‐Farber Cancer Institute between January 2000 June 2006 identified. RESULTS. median survival from time diagnosis 13.3 months. Sixteen (14%) diagnosed CNS involvement initial diagnosis;...
Abstract BACKGROUND No age‐adjusted or histologic‐adjusted assessments of the association between extent resection and risk either recurrence death exist for neurosurgical patients who undergo low‐grade glioma using intraoperative magnetic resonance image (MRI) guidance. METHODS The current data included 156 underwent surgical a unifocal, supratentorial, in MRI suite at Brigham Women's Hospital January 1, 1997, 31, 2003. Estimates disease‐free overall survival probabilities were calculated...
Significant gaps exist in our understanding of the causes and clinical management glioma. One biggest is how best to manage low-grade (World Health Organization [WHO] Grade II) Low-grade glioma (LGG) a uniformly fatal disease young adults (mean age 41 years), with survival averaging approximately 7 years. Although LGG patients have better than high-grade (WHO III or IV) glioma, all LGGs eventually progress death. Data from Surveillance, Epidemiology End Results (SEER) program National Cancer...
The familial risk of breast cancer was investigated in a large population-based, case-control study conducted by the Centers for Disease Control. data set included 4,730 histologically confirmed cases aged 20-54 years and 4,688 controls who were frequency matched to geographic region 5-year categories age. Family history among first-degree female relatives utilized. To identify factors associated with cancer, Cox proportional hazards model used, modeling time onset mothers sisters. Case at...
Population-based estimates of the incidence and prognosis brain metastases at diagnosis breast cancer are lacking.To characterize proportions median survivals patients with time diagnosis.Patients were identified using Surveillance, Epidemiology, End Results (SEER) database National Cancer Institute. Data stratified by subtype, age, sex, race. Multivariable logistic Cox regression performed to identify predictors presence factors associated all-cause mortality, respectively. For incidence,...
Gliomas are the most common brain tumor, with several histological subtypes of various malignancy grade. The genetic contribution to familial glioma is not well understood. Using whole exome sequencing 90 individuals from 55 families, we identified two families mutations in POT1 (p.G95C, p.E450X), a member telomere shelterin complex, shared by both affected each family and predicted impact DNA binding TPP1 binding, respectively. Validation separate cohort 264 246 an additional mutation...
Meningiomas are the most common primary intracranial tumor in adults. Clinical care is currently guided by World Health Organization (WHO) grade assigned to meningiomas, a 3-tiered grading system based on histopathology features, as well extent of surgical resection. behavior, however, often fails conform WHO grade. Additional prognostic information needed optimize patient management.We evaluated whether chromosomal copy-number data improved prediction time-to-recurrence for patients with...
OBJECTIVES: The objectives were to identify situational risk factors associated with suffering a serious fall injury and determine whether, what extent, predisposing contributed independently of injury. DESIGN: Nested cohort study. SETTING: General community. PARTICIPANTS: 568 members representative sample community‐living persons 72 years age or older who fell during median follow‐up 36 months. MEASUREMENTS: Candidate factors, identified baseline face‐to‐face home assessment, the...
Abstract BACKGROUND Detailed population‐based estimates of long‐term survival as well patterns care for patients with low‐grade gliomas examined by age at diagnosis, gender, and race have not been widely available. METHODS Time to death was among 2009 individuals diagnosed a supratentorial glioma reported the Surveillance, Epidemiology, End Results (SEER) program National Cancer Institute from 1973–2001 using Kaplan–Meier estimation. A Cox proportional hazards model used assess effect race,...
Abstract BACKGROUND: Ionizing radiation is a consistently identified and potentially modifiable risk factor for meningioma, which the most frequently reported primary brain tumor in United States. The objective of this study was to examine association between dental x‐rays—the common artificial source ionizing radiation—and intracranial meningioma. METHODS: This population‐based case‐control included 1433 patients who had meningioma diagnosed at ages 20 79 years were residents states...
Background Integration of data from clinical trials and advancements in technology predict a change selection for treatment patients with cerebral aneurysm. Objective To describe patterns use in-hospital mortality associated surgical endovascular treatments aneurysms over the past decade. Materials methods The are 34 899 hospital discharges diagnosis ruptured or unruptured aneurysm 1998 to 2007 identified Nationwide Inpatient Sample (NIS). rates coiling clipping among an examined decade by...
Object The authors conducted a study to determine population-based estimates of survival following the diagnosis and treatment nonmalignant intracranial meningioma in US modern era. Methods Patients with were identified through Surveillance, Epidemiology, End Results (SEER) database for years 2004–2007. Predictors undergoing resection odds ratios calculated. Estimates calculated using Kaplan-Meier estimation method Cox proportional hazards model. There 12,284 patients included analysis. Only...
Object The 2-fold higher incidence of meningioma in women compared with men has long suggested a role for hormonally mediated risk factors, but specific mechanisms remain elusive. Methods study included data obtained 1127 29–79 years age intracranial diagnosed among residents Connecticut, Massachusetts, North Carolina, the San Francisco Bay Area, and 8 Texas counties between May 1, 2006, October 6, 2011, 1092 control individuals who were frequency matched group geography patients. Results No...