Tali Mazor
A5005519554- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Natural Language Processing Techniques
- Bioinformatics and Genomic Networks
- Genetics, Bioinformatics, and Biomedical Research
- Ferroptosis and cancer prognosis
- Neuroblastoma Research and Treatments
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Colorectal Cancer Treatments and Studies
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Cell Image Analysis Techniques
- Biomedical and Engineering Education
- Cancer Cells and Metastasis
- Biomedical Text Mining and Ontologies
- Virus-based gene therapy research
- Scientific Computing and Data Management
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
Dana-Farber Cancer Institute
2017-2025
Neurological Surgery
2013-2024
University of California, San Francisco
2014-2024
University of Haifa
2014-2024
Boston University
2017-2023
Dana-Farber/Harvard Cancer Center
2020-2021
University of Tübingen
2021
Harvard University
2021
UCSF Helen Diller Family Comprehensive Cancer Center
2017-2021
UCSF Benioff Children's Hospital
2018
Back with a Vengeance After surgery, gliomas (a type of brain tumor) recur in nearly all patients and often more aggressive form. Johnson et al. (p. 189 , published online 12 December 2013) used exome sequencing to explore whether recurrent tumors harbor different mutations than the primary mutational profile recurrences is influenced by postsurgical treatment temozolomide (TMZ), chemotherapeutic drug known damage DNA. In 40% cases, at least half initial glioma were undetected recurrence....
Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 are among first genetic alterations observed during development of lower-grade glioma (LGG). LGG-associated IDH mutations confer gain-of-function activity by converting α-ketoglutarate to oncometabolite R-2-hydroxyglutarate (2HG). Clinical samples gene expression data from The Cancer Genome Atlas (TCGA) demonstrate reduced cytotoxic T lymphocyte-associated IFN-γ-inducible chemokines, including CXCL10, IDH-mutated (IDH-MUT) tumors...
Abstract International cancer registries make real-world genomic and clinical data available, but their joint analysis remains a challenge. AACR Project GENIE, an international registry collecting from 19 centers, makes >130,000 patients publicly available through the cBioPortal for Cancer Genomics (https://genie.cbioportal.org). For 25,000 patients, additional longitudinal data, including treatment outcome are being collected by GENIE Biopharma Collaborative using PRISSMM curation...
SummaryPolycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci mammalian cells remain incompletely understood. In this study we show Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds directly Runx1/CBFβ transcription factor complex. Genome-wide studies megakaryocytic demonstrate significant chromatin occupancy overlap between PRC1 Ring1b and functional regulation considerable fraction...
Significance Identifying the drivers of tumorigenesis provides insight into mechanisms transformation and can suggest novel therapeutic targets. IDH1 mutations in gliomas are one such promising target. Drivers tumor initiation may be distinct from those at recurrence, however. Here, we demonstrate that a subset initially mutant is deleted or amplified yielding higher grade with reprogrammed epigenome. We also report systematic selection for cells CNA vitro vivo. Thus, while mutation likely...
Cancer classification is foundational for patient care and oncology research. Systems such as International Classification of Diseases Oncology (ICD-O), Systematized Nomenclature Medicine Clinical Terms (SNOMED-CT), National Institute Thesaurus (NCIt) provide large sets cancer terminologies but they lack a dynamic modernized platform that addresses the fast-evolving needs in clinical reporting genomic sequencing results associated research.To meet these needs, we have developed OncoTree, an...
Chemotherapy improves overall survival after surgery and radiotherapy for newly diagnosed high-risk IDH-mutant low-grade gliomas (LGGs), but a proportion of patients treated with temozolomide (TMZ) will develop recurrent tumors TMZ-induced hypermutation. We aimed to determine the prevalence hypermutation at recurrence prognostic implications.We sequenced from 82 initially who underwent reoperation correlated status grade subsequent clinical outcomes.Hypermutation was associated high-grade...
The American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) is an international pan-cancer registry with the goal to inform cancer research and clinical care worldwide. Founded in late 2015, milestone GENIE 9.1-public release contains data from >110,000 tumors >100,000 people treated at 19 centers United States, Canada, Kingdom, France, Netherlands, Spain. Here, we demonstrate use of these real-world data, harmonized through a...
We have used a simple and efficient method to identify condition-specific transcriptional regulatory sites in vivo help elucidate the molecular basis of sex-differences transcription, which are widespread mammalian tissues affect normal physiology, drug response, inflammation disease.To systematically uncover regulators responsible for these differences, we DNase hypersensitivity analysis coupled with high-throughput sequencing produce maps male female mouse liver, livers mice feminized by...
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder of childhood caused by mutations in the Ras pathway. Outcomes JMML vary markedly from spontaneous resolution to rapid relapse after hematopoietic stem cell transplantation. Here, we hypothesized that DNA methylation patterns would help predict disease outcome and therefore performed genome-wide profiling cohort 39 patients. Unsupervised hierarchical clustering identifies three clusters Importantly, these differ...
Understanding the mechanistic basis of transcriptional regulation has been a central focus molecular biology since its inception. New high-throughput chromatin immunoprecipitation experiments have revealed that most regulatory proteins bind thousands sites in mammalian genomes. However, functional significance these binding remains unclear. We present quantitative model suggests contribution each site to tissue-specific gene expression depends strongly on position relative transcription...
Abstract Mutations in the isocitrate dehydrogenase gene IDH1 are common low-grade glioma, where they result production of 2-hydroxyglutarate (2HG), disrupted patterns histone methylation, and gliomagenesis. mutations also cosegregate with ATRX TERT promoter, suggesting that IDH mutation may drive creation or selection telomere-stabilizing events as part immortalization/transformation process. To determine whether how this occur, we investigated phenotype pRb-/p53-deficient human astrocytes...
Widespread, comprehensive sequencing of patient tumors has facilitated the usage precision medicine (PM) drugs to target specific genomic alterations. Therapeutic clinical trials are necessary test new PM advance medicine, however, abundance data coupled with complex trial eligibility made it challenging match patients trials. To facilitate enrollment onto trials, we developed MatchMiner, an open-source platform computationally genomically profiled cancer Here, describe MatchMiner's...
In Huntington's disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of heat shock response
BACKGROUND Activation of the phosphatidylinositol 3‐kinase (PI3K)/mammalian target rapamycin (mTOR) pathway is common in patients with low‐grade gliomas (LGGs), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied population. METHODS Fifty‐eight pathologic evidence recurrence after they had initially diagnosed World Health Organization (WHO) grade II were enrolled into a prospective phase 2 clinical trial and received daily everolimus (RAD001) for 1 year or...
Abstract cBioPortal for Cancer Genomics is a widely used platform exploratory, interactive visualization and analysis of large-scale clinico-genomic datasets. provides range visualizations analyses including cohort exploration, OncoPrints, mutation “lollipop” plots, survival analysis, alteration enrichment detailed patient-level visualizations. also integrates variant annotations from variety sources to facilitate interpretation. The public (https://www.cbioportal.org) accessed by...
Importance Historically, fewer than 10% of adults with cancer have enrolled in clinical trials. Computational tools been developed to match patients trials, but these are relevant only when need new treatment. Objective To evaluate whether notifying oncologists about genomically targeted trials for progression, as detected by artificial intelligence (AI), impacts trial participation. Design, Setting, and Participants This single-center randomized was conducted from January 30, 2023, June...