A5035985085- Glioma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Hormonal Regulation and Hypertension
- Cancer Genomics and Diagnostics
- Inflammatory mediators and NSAID effects
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Pituitary Gland Disorders and Treatments
- Estrogen and related hormone effects
- Carcinogens and Genotoxicity Assessment
- Autoimmune and Inflammatory Disorders Research
- Cancer-related gene regulation
- Parkinson's Disease Mechanisms and Treatments
- Glutathione Transferases and Polymorphisms
- Pharmacogenetics and Drug Metabolism
- Genetic factors in colorectal cancer
- Spondyloarthritis Studies and Treatments
- Lung Cancer Treatments and Mutations
- Hedgehog Signaling Pathway Studies
- Chronic Lymphocytic Leukemia Research
- Mitochondrial Function and Pathology
Linköping University
2015-2024
Science for Life Laboratory
2021-2022
Karolinska Institutet
1982-2014
Karolinska University Hospital
2014
Örebro County Council
2013
Institute of Cell Biology
2012
Advanced Micro Devices (Canada)
2006
Institute for Molecular Medicine Finland
2004
Ryhov Hospital Jönköping
1999
Linköping University Hospital
1988-1997
Loss of heterozygosity data from familial tumors suggest that BRCA1 , a gene confers susceptibility to ovarian and early-onset breast cancer, encodes tumor suppressor. The region is also subject allelic loss in sporadic cancers, an indication mutations may occur somatically these tumors. coding was examined for primary show allele at the locus. Mutations were detected 3 32 1 12 carcinomas; all four germline alterations occurred cancers. These results mutation not be critical development...
Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting in diabetic are lacking. Intriguingly, an association inflammasome activation has recently been shown, but pathophysiological relevance finding remains unknown. Within glomeruli, was detected endothelial cells and podocytes humans mice glucose-stressed glomerular vitro. Abolishing Nlrp3 or caspase-1...
To investigate the associations between Parkinson's disease and other degenerative parkinsonian syndromes environmental factors in five European countries.A case-control study of 959 prevalent cases parkinsonism (767 with disease) 1989 controls Scotland, Italy, Sweden, Romania Malta was carried out. Cases were defined using United Kingdom Disease Society Brain Bank criteria, those drug-induced or vascular dementia excluded. Subjects completed an interviewer-administered questionnaire about...
Effective cancer prevention is based on accurate molecular diagnosis and results of genetic family screening, genotype-informed risk assessment, tailored strategies for early diagnosis. The expanding etiology hereditary pheochromocytomas paragangliomas has recently included SDHA, TMEM127, MAX, SDHAF2 as susceptibility genes. Clinical management guidelines patients with germline mutations in these 4 newly genes are lacking.To study the clinical spectra age-related penetrance individuals...
Pheochromocytomas and paragangliomas have a highly diverse genetic background, with third of the cases carrying germline mutation in 1 14 identified genes.
OBJECTIVES: Crohn's disease (CD) is characterized by overproduction of proinflammatory cytokines like interleukin (IL)-1β. Production mature IL-1β dependent on a caspase-1-activating protein complex called the NALP3 inflammasome, composed NALP3, ASC, and CARD8. shares structural similarities with Nod2, both these proteins are required for bacteria-induced secretion. The combination polymorphismsCARD8(C10X) andNALP3(Q705K) was recently shown to be associated rheumatoid arthritis. Our aim...
Background The Q705K polymorphism in NLRP3 has been implicated several chronic inflammatory diseases. In this study we determine the functional role of commonly occurring using an in-vitro system. Principal Findings NLRP3-WT and NLRP3-Q705K were retrovirally transduced into human monocytic cell line THP-1, followed by assessment IL-1β IL-18 levels culture supernatant. THP-1 cells expressing above variants sorted based upon Green Fluorescent Protein (GFP) expression. Cytokine response to alum...
Colorectal tumors are continuously exposed to an inflammatory environment, which together with mitogenic signals sustain several cancer hallmarks. Nuclear factor-kappa B (NFκB) is a major regulator of inflammation and variation in NFκB-associated genes could potentially be used as biomarkers identify patients increased risk colorectal (CRC) development, and/or rapidly progressing disease. In this study, 348 CRC cases 806 randomly selected healthy individuals from southeastern Sweden were...
// Mohamed Ali Mosrati 1 , Annika Malmström 2 Malgorzata Lysiak Adam Krysztofiak Martin Hallbeck 3 Peter Milos 4 Anna-Lotta 5 Charlotte Bratthäll 6 Michael Strandéus 7 Marie Stenmark-Askmalm 8 Söderkvist Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden Advanced Home Care Pathology Neurosurgery Oncology Oncology, District Hospital, Kalmar, Ryhov Jönköping, Genetics Correspondence to: Mosrati, e-mail: mohamed.ali.mosrati@liu.se Keywords: TERT...
Genetic variants of NLRP3 and NLRP1 are known to modulate levels pro-inflammatory cytokine interleukin (IL)-1β. The purpose this study was investigate the association NLRP3/NLRP1 polymorphisms with susceptibility clinical features malignant melanoma in a Swedish case-control study. Common were investigated sporadic patients healthy controls followed by analysis using logistic regression. variant (rs35829419) significantly more common male than (OR, 2.22; CI, 1.27-3.86). Upon stratification,...
Pheochromocytomas are neuroendocrine tumors of the adrenal medulla which can occur either sporadically or in context hereditary tumor syndromes. Whereas genetic background pheochromocytomas is becoming rather well-defined, very little known about more common sporadic form disease constitutes ∼70% all cases. In this study, we elucidate some molecular mechanisms behind pheochromocytoma by performing a comprehensive analysis copy number alterations, gene expression, promoter methylation and...
Abstract Purpose: P-glycoprotein, encoded by the mdr-1 gene, confers multidrug resistance to a variety of antineoplastic agents, e.g., paclitaxel. Recently, different polymorphisms in gene have been identified and their consequences for function as well treatment response P-glycoprotein substrates, are being clarified. We analyzed allelic frequencies at polymorphic sites G2677T/A C3435T ovarian cancer patients with good or poor paclitaxel combination carboplatin order evaluate predictive...
Experimental, clinical, and epidemiological studies have implicated mitogenic metabolites of arachidonic acid such as prostaglandin E(2) (PGE(2)) in colorectal carcinogenesis. Recently, cyclooxygenase 2 (COX-2) which catalyses the conversion to PGE(2), has displayed increased levels human cancer.To evaluate whether there is differential COX-2 expression from different locations (caecum, ascending, transverse, descending, or sigmoid colon, rectum) cancer.Protein were determined by western...
Objectives. The genetic background to RA is incompletely understood. As new cytokine-targeted therapies emerge, early predictors of disease severity are becoming increasingly important. inflammasomes essential regulators cytokine production. We investigated whether two polymorphisms in the genes encoding cryopyrin (CIAS1) and TUCAN (CARD8) influence susceptibility course RA. Methods. Genotype frequencies were assessed 174 Swedish patients with 360 population-based controls without rheumatic...
Abstract Objective NALP3, ASC, and TUCAN are components of the NALP3 inflammasome, which triggers caspase 1–mediated interleukin‐1β (IL‐1β) release. Activating mutations in gene encoding ( NLRP3 ) have recently been linked to familial periodic fever syndromes. We undertook this study determine whether a patient with arthritis antibiotic‐resistant carried genes inflammasome. Methods Genetic analysis CARD‐8 was performed on genomic DNA from population‐based collection (806 subjects). For vitro...
Abstract: The purpose of this study was to evaluate the role sequence variants in CYP2C8, ABCB1 and CYP3A4 genes phenotype for pharmacokinetics toxicity paclitaxel ovarian cancer patients. Thirty‐eight patients were treated with carboplatin. genotypes CYP2C8*1B, *1C, *2, *3, *4, *5, *6, *7, *8 P404A, G2677T/A C3435T, as well CYP3A4*1B, determined by pyrosequencing. Phenotyping performed vivo quinine a probe. monitored 23 underwent more extensive neurotoxicity evaluation. Patients...
To investigate associations of Parkinson's disease (PD) and parkinsonian syndromes with polymorphic genes that influence metabolism either foreign chemical substances or dopamine to seek evidence gene-environment interaction effects modify risk.A case-control study 959 prevalent cases parkinsonism (767 PD) 1989 controls across five European centres. Occupational hygienists estimated the average annual intensity exposure solvents, pesticides metals, (iron, copper, manganese), blind status....
NACHT leucine-rich repeat- and PYD-containing (NLRP)3 protein controls the inflammasome by regulating caspase-1 activity interleukin (IL)-1β processing. The contribution of IL-1β in pathogenesis psoriasis is well recognized. Polymorphisms NLRP3 caspase recruitment domain-containing (CARD)8, a negative regulator activity, have been associated with susceptibility to common inflammatory diseases, such as Crohn's disease rheumatoid arthritis. To investigate role for genetic variants...