A5021804500- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Hidradenitis Suppurativa and Treatments
- Eosinophilic Esophagitis
- Celiac Disease Research and Management
- Liver Diseases and Immunity
- Gut microbiota and health
- Autoimmune and Inflammatory Disorders
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Intestinal and Peritoneal Adhesions
- Health Systems, Economic Evaluations, Quality of Life
- Digestive system and related health
- IL-33, ST2, and ILC Pathways
- Clostridium difficile and Clostridium perfringens research
- Infant Nutrition and Health
- Autoimmune Bullous Skin Diseases
- Gastrointestinal motility and disorders
- Esophageal and GI Pathology
- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- Dermatology and Skin Diseases
- Immunodeficiency and Autoimmune Disorders
Örebro University
2012-2022
Örebro University Hospital
2008-2021
LMU Klinikum
2008
Karolinska Institutet
1997-2003
Örebro County Council
2003
Itasca Consultants (France)
2002
University Gastroenterology
1991-2002
Medical Center Hospital
2001
Linköping University Hospital
1991-1995
University of Oxford
1994
By running the Swedish twin registry containing about 25,000 pairs of twins same sex together with central national diagnosis register hospital inpatients, 80 suffering from inflammatory bowel disease were found. In ulcerative colitis group one 16 monozygotic was concordant for disease, but all other 20 (dizygotic or unknown zygosity) discordant. Crohn's eight 18 and 26 dizygotic concordant. The proband concordance rate among 6.3% 58.3% disease. calculated heritability liability based on...
BACKGROUND: Data on collagenous colitis have been based a limited number of patients. AIMS: To obtain more information this disease from register set up at Orebro Medical Center Hospital. PATIENTS AND METHODS: Twenty five Swedish hospitals contributed to patient register, which comprises 163 histopathologically verified cases. Clinical data were retrospectively analysed. RESULTS: Collagenous followed chronic intermittent course in most cases (85%) with sudden onset 42%. Symptoms watery...
The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution metabolites produced by gut microbiota towards status host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was discern masses thousands in fecal samples collected from 17 identical twin pairs, including healthy individuals those with CD. Pathways differentiating...
A history of appendectomy is rare in patients with ulcerative colitis. This suggests a protective effect or that appendicitis and colitis are alternative inflammatory responses. We sought to characterize this inverse relation further.
Large interindividual variation in the composition of intestinal microbiota between unrelated individuals has made it challenging to identify specific aspects dysbiosis that lead Crohn's disease (CD).To reduce variations exposure during establishment gut flora and influence genotype, we studied mucosa-associated monozygotic twin pairs were discordant (n = 6) or concordant 4) for CD. DNA was extracted from biopsies collected 5 locations ileum rectum. Bacterial 16S ribosomal RNA genes...
Crohn's disease (CD) is an inflammatory bowel of complex etiology, although dysbiosis the gut microbiota has been implicated in chronic immune-mediated inflammation associated with CD. Here we combined shotgun metagenomic and metaproteomic approaches to identify potential functional signatures CD stool samples from six twin pairs that were either healthy, or had ileum (ICD) colon (CCD). Integration these omics revealed several genes, proteins, pathways primarily differentiated ICD healthy...
A population case controlled study of smoking habits at the time diagnosis was done in 260 patients with ulcerative colitis and 144 Crohn9s disease. Smokers had a decreased risk acquiring comparison never smokers (relative 0.7) which appeared to be dose dependent. In former rebound effect seen, especially heavy smokers, where sharply increased 4.4). No sex difference recorded. Smoking doubled disease without any dependent pattern. non-significantly observed. This might caused by carry over...
Background A familial defect in intestinal barrier function has been found Crohn’s disease. Aim To investigate possible genetic and environmental influences on this by studying permeability both relatives spouses of patients with Subjects The study included 39 disease, 34 healthy first degree relatives, 22 spouses. Twenty nine volunteers served as controls. Methods Intestinal was assessed the lactulose:mannitol ratio five hour urinary excretion after oral load, before (baseline) ingestion...
The incidence and prevalence of collagenous colitis are unknown. An epidemiological study was undertaken between 1984-93. All patients living in the immediate catchment area Orebro Medical Center Hospital with diagnosis were identified. Biopsy specimens classified as unspecific intestinal fibrosis re-examined to identify cases not correctly diagnosed at first. records scrutinised colorectal biopsy re-evaluated. Thirty during period. female:male ratio 9:1. median age 64 (28-78) years. 31...
Aliment Pharmacol Ther 2010; 32: 984–989 Summary Background The long‐term efficacy of infliximab as rescue therapy in steroid‐refractory ulcerative colitis is not well described. Aim To examine the a through 3‐year follow‐up previous placebo‐controlled trial acute colitis. Method In original study, 45 patients were randomized to single infusion 5 mg/kg or placebo, and at 3 months, 7/24 given operated vs. 14/21 placebo. Three years later, asked participate clinical follow‐up. Results Another...
Genetics and environmental factors are implicated in the etiology of inflammatory bowel disease (IBD). We studied a population-based Swedish-Danish twin cohort using co-twin control method.A questionnaire was sent to 317 pairs regarding markers exposures following areas: infections/colonization diet as well smoking, appendectomy, oral contraceptives. Odds ratios (OR) were calculated by conditional logistic regression. When confounding appeared plausible, multivariate regression added. The...