A5030677256- Metabolomics and Mass Spectrometry Studies
- Isotope Analysis in Ecology
- Marine and coastal ecosystems
- Analytical Chemistry and Chromatography
- Astro and Planetary Science
- Mass Spectrometry Techniques and Applications
- Fermentation and Sensory Analysis
- Gut microbiota and health
- Microfluidic and Capillary Electrophoresis Applications
- Microbial Community Ecology and Physiology
- Planetary Science and Exploration
- Horticultural and Viticultural Research
- Advanced Chemical Sensor Technologies
- Water Treatment and Disinfection
- Atmospheric chemistry and aerosols
- Analytical chemistry methods development
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Bacterial biofilms and quorum sensing
- Diet and metabolism studies
- Water Quality Monitoring and Analysis
- Plant-Microbe Interactions and Immunity
- Methane Hydrates and Related Phenomena
- Atmospheric and Environmental Gas Dynamics
- Advanced Proteomics Techniques and Applications
Technical University of Munich
2016-2025
Helmholtz Zentrum München
2016-2025
Max Planck Institute for Extraterrestrial Physics
2022-2025
Helmholtz Association of German Research Centres
2023-2025
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2015-2024
Punjabi University
2024
Goddard Space Flight Center
2024
Weihenstephan-Triesdorf University of Applied Sciences
2014-2023
University of Maryland Center for Environmental Science
2019-2023
Institute of Bioinformatics and Systems Biology
2010-2023
Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and glutathione levels to degenerative processes tumor suppression. By performing a genome-wide activation screen, we identified cohort genes antagonizing ferroptotic death, including GTP cyclohydrolase-1 (GCH1) its metabolic derivatives tetrahydrobiopterin/dihydrobiopterin (BH4/BH2). Synthesis BH4/BH2 by GCH1-expressing cells caused lipid remodeling, suppressing ferroptosis selectively preventing depletion...
The asteroid impact near the Russian city of Chelyabinsk on 15 February 2013 was largest airburst Earth since 1908 Tunguska event, causing a natural disaster in an area with population exceeding one million. Because it occurred era modern consumer electronics, field sensors, and laboratory techniques, unprecedented measurements were made event meteoroid that caused it. Here, we document account what happened, as understood now, using comprehensive data obtained from astronomy, planetary...
Numerous descriptions of organic molecules present in the Murchison meteorite have improved our understanding early interstellar chemistry that operated at or just before birth solar system. However, all molecular analyses were so far targeted toward selected classes compounds with a particular emphasis on biologically active components context prebiotic chemistry. Here we demonstrate nontargeted ultrahigh-resolution analysis solvent-accessible fraction extracted under mild conditions allows...
Because of its availability, ease collection, and correlation with physiology pathology, urine is an attractive source for clinical proteomics/peptidomics. However, the lack comparable data sets from large cohorts has greatly hindered development proteomics. Here, we report establishment a reproducible, high resolution method peptidome analysis naturally occurring human urinary peptides proteins, ranging 800 to 17,000 Da, using samples 3,600 individuals analyzed by capillary electrophoresis...
The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution metabolites produced by gut microbiota towards status host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was discern masses thousands in fecal samples collected from 17 identical twin pairs, including healthy individuals those with CD. Pathways differentiating...
Soils, sediments, freshwaters, and marine waters contain natural organic matter (NOM), an exceedingly complex mixture of compounds that collectively exhibit a nearly continuous range properties (size-reactivity continuum). NOM is composed mainly carbon, hydrogen, oxygen, with minor contributions from heteroatoms such as nitrogen, sulfur, phosphorus. Suwannee River fulvic acid (SuwFA) fraction relatively depleted in heteroatoms. Ultrahigh resolution Fourier transform ion cyclotron (FTICR)...
Abstract. High-performance, non-target, high-resolution organic structural spectroscopy was applied to solid phase extracted marine dissolved matter (SPE-DOM) isolated from four different depths in the open South Atlantic Ocean off Angola coast (3° E, 18° S; Basin) and provided molecular level information with extraordinary coverage resolution. Sampling performed at of 5 m (Angola Current; near-surface photic zone), 48 fluorescence maximum), 200 (still above Antarctic Intermediate Water,...
Metabolic challenge protocols, such as the oral glucose tolerance test, can uncover early alterations in metabolism preceding chronic diseases. Nevertheless, most metabolomics data accessible today reflect fasting state. To analyze dynamics of human metabolome response to environmental stimuli, we submitted 15 young healthy male volunteers a highly controlled 4 d protocol, including 36 h fasting, and lipid tests, liquid test meals, physical exercise, cold stress. Blood, urine, exhaled air,...
<h3>Objective</h3> Iron deficiency is a common complication in patients with IBD and oral iron therapy suggested to exacerbate symptoms. We performed an open-labelled clinical trial compare the effects of per (PO) versus intravenous (IV) replacement (IRT). <h3>Design</h3> The study population included Crohn9s disease (CD; N=31), UC (N=22) control subjects (non-inflamed, NI=19). After randomisation, participants received sulfate or sucrose over 3 months. Clinical parameters, faecal bacterial...
ABSTRACT Diet can influence the composition of human microbiome, and yet relatively few dietary ingredients have been systematically investigated with respect to their impact on functional potential microbiome. Dietary resistant starch (RS) has shown health benefits, but we lack a mechanistic understanding metabolic processes that occur in gut during digestion RS. Here, collected samples crossover study diets containing large or small amounts We determined RS microbiome pathways gut, using...
Abstract. Dissolved organic matter (DOM) was extracted by solid-phase extraction (SPE) from 137 water samples different climate zones and depths along an eastern Atlantic Ocean transect. The extracts were analyzed with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) electrospray ionization (ESI). Δ14C analyses performed on subsamples of the SPE-DOM. In addition, amount dissolved carbon determined for all SPE-DOM as well yield amino sugars selected samples. Linear...
Absorbance, 3D fluorescence and ultrahigh resolution electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FT-ICR-MS) were used to explain patterns in the removal of chromophoric fluorescent dissolved organic matter (CDOM FDOM) at molecular level during drinking water production four large treatment plants Sweden. When carbon (DOC) was low, shifts (DOM) composition could not be detected with commonly DOC-normalized parameters (e.g. specific UV254 absorbance...
Short-chain fatty acids (SCFAs), which are generated by the bacterial fermentation of dietary fibers, promote expansion regulatory T cells (Tregs). Potential therapeutic value SCFAs has been recently highlighted in experimental models cell-mediated autoimmunity and allergic inflammation. These studies suggest that physiological intestinal concentrations within millimolar range crucial for dampening inflammation-mediated processes. Here, we describe opposing effects on immune responses. In...
Natural organic matter (NOM) serve as precursors for disinfection byproducts (DBPs) in drinking water production making NOM removal essential predisinfection treatment processes. We identified molecular formulas of chlorinated DBPs after chlorination and chloramination four Swedish surface plants (WTPs) using ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). Chlorine-containing were detected before therefore classified to identify DBPs. In total,...
Altered interactions between the mucosal immune system and intestinal microbiota contribute to pathogenesis of inflammatory bowel diseases (IBD). It is not clear how inhibitors cytokines, such as antagonists tumor necrosis factor (anti-TNF), affect microbiome. We investigated effects anti-TNF agents on gut microbe community structure function in a longitudinal 2-step study patients with IBD. correlated our findings outcomes treatment patterns metabolites fecal samples before after therapy.We...
Traces of life are nearly ubiquitous on Earth. However, a central unresolved question is whether these traces always indicate an active microbial community or whether, in extreme environments, such as hyperarid deserts, they instead reflect just dormant dead cells. Although biomass and diversity decrease with increasing aridity the Atacama Desert, we provide multiple lines evidence for presence at times metabolically active, one driest places We base this observation four major evidence: (i)...
Inventory of an essential marine element Sulfur is necessary for primary production and has a large impact on climate processes. Because it difficult to detect accurately, the amount dissolved organic sulfur in ocean poorly defined. Ksionzek et al. measured Atlantic estimate its distribution infer quantity world's oceans (see Perspective by Levine). The findings suggest that exceeds all other forms factor 10. Science , this issue p. 456 ; see also 418
The commercially available inoculant Bacillus amyloliquefaciens FZB42 is able to considerably reduce lettuce bottom rot caused by Rhizoctonia solani. To understand the interaction between and R. solani in rhizosphere of lettuce, we used an axenic system with bacterized inoculated Confocal laser scanning microscopy showed that could delay initial establishment on plants. show which secondary metabolites are produced under these in-situ conditions, developed ultra-high performance liquid...