Jill S. Barnholtz‐Sloan
A5051948022- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Meningioma and schwannoma management
- Esophageal Cancer Research and Treatment
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Mechanisms of cancer metastasis
- Cancer-related gene regulation
- Genetic Associations and Epidemiology
- Cancer, Lipids, and Metabolism
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Neuroblastoma Research and Treatments
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Gene expression and cancer classification
Division of Cancer Epidemiology and Genetics
2021-2025
National Cancer Institute
2021-2025
Central Brain Tumor Registry of the United States
2016-2025
Case Western Reserve University
2015-2024
University Health System
2020-2024
University School
2014-2024
Center for Information Technology
2021-2024
University Hospitals of Cleveland
2014-2024
National Institutes of Health
2011-2024
Cancer Genetics (United States)
2011-2024
The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with Centers for Disease Control (CDC) and National Cancer Institute (NCI), is largest population-based registry focused exclusively on primary brain other central nervous system (CNS) tumors (US) represents entire US population. This report contains most up-to-date data (malignant non-malignant) supersedes all previous CBTRUS reports terms completeness accuracy. All rates (incidence mortality) are age-adjusted...
Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II III) have highly variable clinical behavior that is not adequately predicted on basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty compounded by interobserver variability in diagnosis. Mutations IDH, TP53, ATRX codeletion chromosome arms 1p 19q (1p/19q codeletion) been implicated as clinically relevant...
Abstract Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation this variation at whole-genome scale 1–3 . Here we report integrative analysis 2,658 whole-cancer genomes their matching normal tissues across 38 tumour types from Pan-Cancer Analysis Whole Genomes (PCAWG) Consortium International Genome (ICGC) The Atlas (TCGA). We describe generation PCAWG resource, facilitated international data sharing using compute clouds. On...
The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with Centers for Disease Control and Prevention National Cancer Institute, is largest population-based registry focused exclusively on primary brain other central nervous system (CNS) tumors (US) represents entire US population. This report contains most up-to-date data available supersedes all previous reports terms completeness accuracy. All rates are age-adjusted using 2000 standard population presented per...
CBTRUS does not collect data directly from patients' medical records.As noted, for analyses come the NPCR and SEER programs.By law, all primary malignant non-malignant brain tumors are reportable diseases.Hence, tumor registrars in treatment centers these send this information to CCR their states where they collated de-identified sent SEER.Brain CNS reported using site definition described Public Law 107-260. 3On an annual basis, secures permission release on CBTRUS.CCR plays essential role...
Population-based estimates of the incidence brain metastases are not generally available. The purpose this study was to calculate population-based proportions (IPs) from single primary lung, melanoma, breast, renal, or colorectal cancer.Patients diagnosed with cancer (1973 2001) in Metropolitan Detroit Cancer Surveillance System (MDCSS) were used for analysis. IP by site and variable interest (race, sex, age at diagnosis cancer, Surveillance, Epidemiology, End Results [SEER] stage cancer)...
The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with Centers for Disease Control (CDC) and National Cancer Institute (NCI), is largest population-based registry focused exclusively on primary brain other central nervous system (CNS) tumors (US) represents entire US population. This report contains most up-to-date data (malignant non-malignant) supersedes all previous CBTRUS reports terms completeness accuracy. All rates (incidence mortality) are age-adjusted...
The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with CDC and NCI, is largest population-based registry focused exclusively on primary brain other central nervous system (CNS) tumors (US) represents entire US population. This report contains most up-to-date data available supersedes all previous reports terms completeness accuracy first CBTRUS Report to provide distribution molecular markers for selected CNS tumor histologies. All rates are age-adjusted using...
Abstract The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with Centers for Disease Control and Prevention National Cancer Institute, is largest population-based registry focused exclusively on primary brain other central nervous system (CNS) tumors (US) represents entire US population. This report contains most up-to-date data available supersedes all previous reports terms completeness accuracy. All rates are age-adjusted using 2000 standard population...
Significance Predicting the expected outcome of patients diagnosed with cancer is a critical step in treatment. Advances genomic and imaging technologies provide physicians vast amounts data, yet prognostication remains largely subjective, leading to suboptimal clinical management. We developed computational approach based on deep learning predict overall survival brain tumors from microscopic images tissue biopsies biomarkers. This method uses adaptive feedback simultaneously learn visual...
Abstract Brain and other central nervous system (CNS) tumors are among the most fatal cancers account for substantial morbidity mortality in United States. Population‐based data from Central Tumor Registry of States (a combined set National Program Cancer Registries [NPCR] Surveillance, Epidemiology, End Results [SEER] registries), NPCR, Vital Statistics System SEER program were analyzed to assess contemporary burden malignant nonmalignant brain CNS (hereafter brain) by histology, anatomic...
Abstract The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with Centers for Disease Control and Prevention National Cancer Institute, is largest population-based registry focused exclusively on primary brain other central nervous system (CNS) tumors (US) represents entire US population. This report contains most up-to-date data available supersedes all previous CBTRUS reports terms completeness accuracy. All rates are age-adjusted using 2000 standard population...
Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, their relationships to histologic features routinely used for diagnosis unclear. We present the Ivy Atlas, anatomically based transcriptional atlas of human glioblastoma aligns individual with genomic alterations gene expression patterns, thus assigning information most important morphologic hallmarks tumor. its clinical database freely accessible online data...