A5060842441- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Chromatin Remodeling and Cancer
- Cancer Genomics and Diagnostics
- Pituitary Gland Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Ocular Oncology and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Epilepsy research and treatment
- Soft tissue tumor case studies
- Fetal and Pediatric Neurological Disorders
- Microtubule and mitosis dynamics
- Adrenal and Paraganglionic Tumors
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Hippo pathway signaling and YAP/TAZ
- Ferroptosis and cancer prognosis
University of California San Francisco Medical Center
2003-2025
University of California, San Francisco
2016-2025
University of Miami
2025
Neurological Surgery
2006-2024
Denali Therapeutics (United States)
2024
Koç University
2016-2022
Hacettepe University
2022
UCSF Benioff Children's Hospital
2020
Connecticut Children's Medical Center
2019
Boston Children's Hospital
2019
The prediction of clinical behavior, response to therapy, and outcome infiltrative glioma is challenging. On the basis previous studies tumor biology, we defined five molecular groups with use three alterations: mutations in TERT promoter, IDH, codeletion chromosome arms 1p 19q (1p/19q codeletion). We tested hypothesis that within based on these features, tumors would have similar variables, acquired somatic alterations, germline variants.We scored as negative or positive for each markers...
Purpose The prognostic role of extent resection (EOR) low-grade gliomas (LGGs) is a major controversy. We designed retrospective study to assess the influence EOR on long-term outcomes LGGs. Patients and Methods population (N = 216) included adults undergoing initial hemispheric LGG. Region-of-interest analysis was performed measure tumor volumes based fluid-attenuated inversion-recovery (FLAIR) imaging. Results Median preoperative postoperative were 36.6 cm 3 (range, 0.7 246.1 ), 3.7 0...
Abstract Brain and other central nervous system (CNS) tumors are among the most fatal cancers account for substantial morbidity mortality in United States. Population‐based data from Central Tumor Registry of States (a combined set National Program Cancer Registries [NPCR] Surveillance, Epidemiology, End Results [SEER] registries), NPCR, Vital Statistics System SEER program were analyzed to assess contemporary burden malignant nonmalignant brain CNS (hereafter brain) by histology, anatomic...
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib (also known as Tarceva or OSI-774) has shown promising response rates in malignant gliomas. We investigated the association between expression of EGFR and downstream signaling components gliomas to a phase I trial administered either alone with alkylating agent temozolomide.Expression ligand-independent EGFRvIII mutant proteins phosphorylated protein B (PKB)/Akt specimens from glioma patients were assessed by...
Fifty-five patients with atypical teratoid/rhabdoid tumors of the central nervous system were studied to define clinical and pathologic features this newly described neoplasm. The lesion occurred primarily in children younger than 2 (mean age at diagnosis, 17 months). neoplasms located posterior fossa (36 patients) supratentorial compartment (17 or multifocal both compartments (2 presentation. Histologically, composed small cells large, pale a jumbled architectural arrangement. cell...
Somatic mutations of the H3F3A and HIST1H3B genes encoding histone H3 variants, H3.3 H3.1, were recently identified in high-grade gliomas arising thalamus, pons spinal cord children young adults. However, complete range patients locations which these tumors arise, as well morphologic spectrum associated genetic alterations remain undefined. Here, we describe a series 47 diffuse midline with H3-K27M mutation. The 25 male 22 female ranged age from 2 to 65 years (median = 14). Tumors centered...
<b>BACKGROUND AND PURPOSE:</b> Plaque morphologic features have been suggested as a complement to luminal narrowing measurements for assessing the risk of stroke associated with carotid atherosclerotic disease, giving rise concept “vulnerable plaque.” The purpose this study was evaluate ability multidetector-row CT angiography (CTA) assess composition and characteristics artery plaques use histologic examination gold standard. <b>MATERIALS METHODS:</b> Eight patients transient ischemic...
Molecular profiling is revolutionizing cancer diagnostics and leading to personalized therapeutic approaches. Herein we describe our clinical experience performing targeted sequencing for 31 pediatric neuro-oncology patients.We sequenced 510 cancer-associated genes from tumor peripheral blood identify germline somatic mutations, structural variants, copy number changes.Genomic was performed on patients with tumors including 11 high-grade gliomas, 8 medulloblastomas, 6 low-grade 1 embryonal...
Among tumors classified as pilocytic astrocytoma (PA) in the Johns Hopkins Hospital Department of Pathology files, we identified 18 cases with a distinctive monomorphous pilomyxoid histological pattern and higher recurrence rate than that PA classical features (classical PA). The majority occurred infants young children involved hypothalamic/chiasmatic region. were histologically similar to PA, but they more myxoid. Rosenthal fibers not seen only 1 had eosinophilic granular bodies. At end...
Relatively little is known about the molecular changes that promote formation or growth of pilocytic astrocytomas. We investigated genomic alterations in 25 astrocytomas, including 5 supratentorial and 20 posterior fossa tumors, using oligonucleotide array comparative hybridization. Large were identified 7 tumors included gains chromosomes 5, 6, losses 16, 17, 19, 22. The most common alteration was a 1.9-MB region low-level gain at chromosome 7q34 17 tumors. In ended within BRAF locus...
Object To investigate the prognostic significance of volumetrically assessed extent resection on time to tumor progression (TTP), overall survival (OS), and recurrence patterns, authors retrospectively analyzed preoperative postoperative volumes in 102 adult patients from initial a hemispheric anaplastic astrocytoma (AA). Methods The quantification was based previously described method involving computerized analysis magnetic resonance (MR) images. Analysis contrast-enhancing T 1 -weighted...
The adenomatous polyposis coli (APC) gene, a member of the Wingless/Wnt signal transduction pathway, has been implicated in development medulloblastomas Turcot's syndrome. β-catenin also functions this highly conserved signaling pathway and is instrumental growth development. Mutations either APC or can stabilize protein. Stabilized complexes with Tcf/Lef transcription factors moves from cytoplasm into nucleus where it regulates c-Myc other genes. Nuclear localization therefore implies...
Brain stem tumors in children have been classified pathologically as low grade or high gliomas and descriptively diffuse gliomas, intrinsic midbrain tumors, tectal pencil dorsal exophytic brain pontine focal medullary cervicomedullary cystic gliomas.To search for a simplified prognostic clinicopathologic scheme the authors reviewed consecutive cohort of patients younger than age 21 years with diagnosed from 1980 through 1997. Pathology specimens neuroimaging were by masked review....
We present 8 examples of a neoplasm with features both astrocytoma and ependymoma that may represent distinct clinicopathologic entity. The cerebral hemispheric tumors occurred in patients were 3, 4, 12, 14, 15, 26, 30, 37 years age. All presented seizures that, the exception 2, began childhood. Magnetic resonance imaging studies showed ill-defined, T2-hyperintense, generally noncontrast-enhancing lesions although centered on cortex or amygdala, extended into underlying white matter for...
OBJECTIVE Pilocytic astrocytoma (PA) is a common type of pediatric brain tumor that can arise within the hypothalamic/chiasmatic region and typically has an excellent outcome. We identified group tumors, previously classified as PAs, with unique histological features aggressive behavior. This article describes clinicopathological these unusual neoplasms, which are currently known pilomyxoid astrocytomas (PMAs), to better differentiate them from typical PAs. METHODS Medical information...