A5026977235- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- ATP Synthase and ATPases Research
- Neural and Behavioral Psychology Studies
- Pancreatic and Hepatic Oncology Research
- Functional Brain Connectivity Studies
- Cancer-related cognitive impairment studies
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Neuroblastoma Research and Treatments
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Advanced MRI Techniques and Applications
- Cancer Genomics and Diagnostics
- Memory and Neural Mechanisms
- Brain Metastases and Treatment
- Brain Tumor Detection and Classification
- Schizophrenia research and treatment
- Obsessive-Compulsive Spectrum Disorders
- Stroke Rehabilitation and Recovery
- Multiple Sclerosis Research Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Congenital heart defects research
- Smoking Behavior and Cessation
University of California, San Francisco
2015-2024
University of California System
2010-2024
University of California, San Diego
2021
Simons Foundation
2021
Laboratoire d’Imagerie Biomédicale
2019-2020
University of Chicago
1998
PURPOSE In patients with diffuse low-grade glioma (LGG), the extent of surgical tumor resection (EOR) has a controversial role, in part because randomized clinical trial different levels EOR is not feasible. METHODS 20-year retrospective cohort 392 IDH-mutant grade 2 glioma, we analyzed combined effects volumetric and molecular factors on overall survival (OS) progression-free by recursive partitioning analysis. The OS results were validated two external cohorts (n = 365). Propensity score...
PNOC003 is a multicenter precision medicine trial for children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG).
Abstract Background The objective of this study was to determine the safety, tolerability, and distribution MTX110 (aqueous panobinostat) delivered by convection-enhanced delivery (CED) in patients with newly diagnosed diffuse intrinsic pontine glioma (DIPG) who completed focal radiation therapy (RT). Methods Patients DIPG (2–21 years) were enrolled after RT. CED combined gadoteridol across 7 dose levels (DL) (30–90 µM; volumes ranging from 3 mL 2 consecutive doses 6 mL). An accelerated...
Patients who suffer from the devastating psychiatric illness schizophrenia are plagued by hallucinations, bizarre behavior, and delusional ideas, such as believing that they controlled malevolent outside forces. A fundamental human cognitive operation may contribute to these hallmark symptoms is ability maintain accurate coherent self-referential processing over time, occurs during reality monitoring (distinguishing self-generated externally perceived information). However, neural bases for...
Traumatic brain injury (TBI) is one of the leading causes morbidity worldwide. One mechanism by which blunt head trauma may disrupt normal cognition and behavior through alteration functional connectivity between regions. In this pilot study, authors applied a rapid automated resting state magnetoencephalography (MEG) imaging technique suitable for routine clinical use to test hypothesis that there decreased in patients with TBI compared matched controls, even cases mild TBI. Furthermore,...
Although it is well established that multiple frontal, parietal, and occipital regions in humans are involved anticipatory deployment of visual spatial attention, less known about the electrophysiological signals each region across subsecond periods attentional deployment. We used MEG measures cortical stimulus-locked, signal-averaged (event-related field) activity during a task which symbolic cue directed covert attention to relevant location on trial. Direction-specific effects occurred...
Our aim was to evaluate differences in metabolite levels between unmedicated patients with major depressive disorder (MDD) and healthy controls, assess changes metabolites after they completed an 8-week course of mindfulness-based cognitive therapy (MBCT), exam the correlation depression severity. Sixteen MDD ten age- gender-matched controls were studied using 3D short echo-time (20 ms) magnetic resonance spectroscopic imaging (MRSI) at 7 Tesla. Relative ratios estimated five regions...
Abstract Background Diagnostic classification of diffuse gliomas now requires an assessment molecular features, often including IDH-mutation and 1p19q-codeletion status. Because genetic testing invasive process, alternative noninvasive approach is attractive, particularly if resection not recommended. The goal this study was to evaluate the effects training strategy incorporation biologically relevant images on predicting subtypes with deep learning. Methods Our dataset consisted 384...
Abstract Background Lower-grade gliomas (LGGs) with isocitrate dehydrogenase 1 and/or 2 (IDH1/2) mutations have long survival times, making evaluation of treatment efficacy difficult. We investigated the volumetric growth rate IDH mutant before and after established glioma therapies to determine whether a significant change in could be documented perhaps used future evaluate response investigational agents LGG trials. Methods In this multicenter retrospective study, 230 adult patients IDH1/2...
Journal Article Adolescent Smokers Show Decreased Brain Responses to Pleasurable Food Images Compared With Nonsmokers Get access Mark L. Rubinstein, M.D., M.D. 1Department of Pediatrics, Division Medicine, University California, San Francisco, CA Search for other works by this author on: Oxford Academic PubMed Google Scholar Tracy Luks, Ph.D., Ph.D. 2Department Radiology, Wendy Y. Dryden, B.A., B.A. Michelle A. Rait, M.A., M.A. Gregory V. Simpson, Nicotine & Tobacco Research, Volume 13,...
The supplementary motor area (SMA) is an eloquent region that frequently a site for glioma, or the included in resection trajectory to deeper lesions. Although clinical relevance of SMA syndrome has been well described, it still difficult predict who will become symptomatic. object this study was define which patients with gliomas would go on develop postoperative syndrome.