Michael Lankerovich
A5069985698- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Molecular Biology Techniques and Applications
- Bioinformatics and Genomic Networks
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- RNA Research and Splicing
Swedish Medical Center
2013-2018
Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, their relationships to histologic features routinely used for diagnosis unclear. We present the Ivy Atlas, anatomically based transcriptional atlas of human glioblastoma aligns individual with genomic alterations gene expression patterns, thus assigning information most important morphologic hallmarks tumor. its clinical database freely accessible online data...
RNA-seq has spurred important gene fusion discoveries in a number of different cancers, including lung, prostate, breast, brain, thyroid and bladder carcinomas. Gene discovery can potentially lead to the development novel treatments that target underlying genetic abnormalities. In this study, we provide comprehensive view landscape 185 glioblastoma multiforme patients from two independent cohorts. Fusions occur approximately 30-50% GBM patient samples. Ivy Center cohort 24 patients, 33%...
The molecular and cellular landscape of glioblastoma is highly complex its relationship to histologic features routinely used for diagnosis unclear. To investigate this relationship, we generated an anatomic transcriptional atlas human glioblastoma, adopting a highly-systematized, large-scale, histology-driven approach the characterization cancer stem cell populations. 42 tumors consists several data modalities, including 270 transcriptomes, ∼11,500 semi-annotated pathology images registered...