A5048152591- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Glioma Diagnosis and Treatment
- Mathematical Biology Tumor Growth
- Bioinformatics and Genomic Networks
- Consumer Perception and Purchasing Behavior
- Chromatin Remodeling and Cancer
- Prenatal Screening and Diagnostics
- Chemical Reactions and Isotopes
- Cell Image Analysis Techniques
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Cancer Genomics and Diagnostics
- Gene Regulatory Network Analysis
- RNA Research and Splicing
- Fashion and Cultural Textiles
- Diverse Topics in Contemporary Research
- Cultural and Historical Studies
- Hedgehog Signaling Pathway Studies
- Religious Studies and Spiritual Practices
- Landscape and Cultural Studies
- MicroRNA in disease regulation
Swedish Medical Center
2011-2024
Neuroscience Institute
2024
Institute for Systems Biology
2007
University of Iowa
2007
Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, their relationships to histologic features routinely used for diagnosis unclear. We present the Ivy Atlas, anatomically based transcriptional atlas of human glioblastoma aligns individual with genomic alterations gene expression patterns, thus assigning information most important morphologic hallmarks tumor. its clinical database freely accessible online data...
Abstract Promoter hypermethylation and histone deacetylation are common epigenetic mechanisms implicated in the transcriptional silencing of tumor suppressor genes human cancer. We treated two immortalized glioma cell lines, T98 U87, 10 patient-derived primary lines with trichostatin A (TSA), a deacetylase inhibitor, or 5-aza-2′-deoxycytidine (5-AzaC), DNA methyltransferase to comprehensively identify cohort reactivated through pharmacologic reversal these distinct but related processes....
O6-methylguanine DNA-methyltransferase (MGMT) promoter methylation has been identified as a potential prognostic marker for glioblastoma patients. The relationship between the exact site of and its effect on gene silencing, patient's subsequent response to therapy, is still being defined. aim this study was comprehensively characterize cytosine-guanine (CpG) dinucleotide across entire MGMT correlate individual CpG patterns mRNA expression, protein progression-free survival. To best identify...
RNA-seq has spurred important gene fusion discoveries in a number of different cancers, including lung, prostate, breast, brain, thyroid and bladder carcinomas. Gene discovery can potentially lead to the development novel treatments that target underlying genetic abnormalities. In this study, we provide comprehensive view landscape 185 glioblastoma multiforme patients from two independent cohorts. Fusions occur approximately 30-50% GBM patient samples. Ivy Center cohort 24 patients, 33%...
// Biaoyang Lin 1, 2, 3 , Hwahyung Lee 4 Jae-Geun Yoon Anup Madan 4, 6 Elizabeth Wayner Sanja Tonning Parvinder Hothi Brett Schroeder Ilya Ulasov Gregory Foltz Leroy Hood 5 Charles Cobbs 1 Cancer Institute (Key Laboratory of Prevention and Intervention, China National Ministry Education), The Second Affiliated Hospital, Zhejiang University School Medicine, Hangzhou, 310003, 2 Dept. Urology, Washington, Seattle, WA 98195, USA System Biology Division, Zhejiang-California International...
Neuro-oN cologyMedulloblastoma is a heterogeneous pediatric brain tumor with significant therapy-related morbidity, its five-year survival rates ranging from 30% to 70%.Improvement in diagnosis and therapy requires better understanding of medulloblastoma pathology.We used whole-genome microarray analysis identify putative suppressor genes silenced by epigenetic mechanisms medulloblastoma.This yielded 714 upregulated immortalized cell line D283 on treatment histone deacetylase (HDAC)...
Poor prognosis and drug resistance in glioblastoma (GBM) can result from cellular heterogeneity treatment-induced shifts phenotypic states of tumor cells, including dedifferentiation into glioma stem-like cells (GSCs). This rare tumorigenic cell subpopulation resists temozolomide, undergoes proneural-to-mesenchymal transition (PMT) to evade therapy, drives recurrence. Through inference transcriptional regulatory networks (TRNs) patient-derived GSCs (PD-GSCs) at single-cell resolution, we...
Maspin, a tumour suppressor gene, is differentially expressed in the human placenta. Decreased expression of maspin first trimester corresponds with period maximum trophoblast invasion, suggesting role cell invasion and motility. Although methylation CpG islands regulates cancer cells, mechanism regulation placenta unknown. Our objectives were to determine epigenetic alterations Placental samples obtained from 7 40 weeks' gestation used for bisulphite sequencing chromatin immunoprecipitation...
ABSTRACT Poor prognosis and drug resistance in glioblastoma (GBM) can result from cellular heterogeneity treatment-induced shifts phenotypic states of tumor cells, including dedifferentiation into glioma stem-like cells (GSCs). This rare tumorigenic cell subpopulation resists temozolomide, undergoes proneural-to-mesenchymal transition (PMT) to evade therapy, drives recurrence. Through inference transcriptional regulatory networks (TRNs) patient-derived GSCs (PD-GSCs) at single-cell...
ABSTRACT Grade IV glioma, formerly known as glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor, its treatment remains challenging in part due to extensive interpatient heterogeneity disease driving mechanisms lack prognostic predictive biomarkers. Using mechanistic inference node-edge relationship (MINER), we have analyzed multiomics profiles from 516 patients constructed an atlas causal drivers GBM (gbmMINER). The has delineated how 30 driver mutations act a...
Abstract Introduction: KISS1 metastatic suppressor is a negative regulator of tumor progression. Recently, we described that breast cancer cells to the brain exhibit much lower level expression detected by real time PCR and IHC. However little known about mechanism regulates in promotes metastases. We hypothesized loss allows persistence brain. Results: Given fact some migrating possess stem (CSC) properties, stained primary clinical specimens contain using CD24, CD44, ESA1 markers. observed...
<p>Supplementary Figures S1-S6 and Table S1</p>
<div>Abstract<p>Promoter hypermethylation and histone deacetylation are common epigenetic mechanisms implicated in the transcriptional silencing of tumor suppressor genes human cancer. We treated two immortalized glioma cell lines, T98 U87, 10 patient-derived primary lines with trichostatin A (TSA), a deacetylase inhibitor, or 5-aza-2′-deoxycytidine (5-AzaC), DNA methyltransferase to comprehensively identify cohort reactivated through pharmacologic reversal these distinct but...
<div>Abstract<p>Promoter hypermethylation and histone deacetylation are common epigenetic mechanisms implicated in the transcriptional silencing of tumor suppressor genes human cancer. We treated two immortalized glioma cell lines, T98 U87, 10 patient-derived primary lines with trichostatin A (TSA), a deacetylase inhibitor, or 5-aza-2′-deoxycytidine (5-AzaC), DNA methyltransferase to comprehensively identify cohort reactivated through pharmacologic reversal these distinct but...
<p>Supplementary Figures S1-S6 and Table S1</p>
We can get a glimpse of Koreans' ideas from our traditional costume culture. Koreans had communication-oriented community consciousness that recognized clothes as “our clothes” rather than individual exclusive, and thought clothing medium for expressing courtesy wanted to dress with dignity when there were major ceremonies. As shown in the white seasonal customs, we have enjoyed culture reflects purity nature awes birth life, management newborns. In addition activity dressing, liberation...
신적 존재인 환웅이나 지상적 곰이 모두가 인간세상을 동경하고 마침내 뜻을 실현한다는 것은 <단군신화>가 지닌 휴머니즘적 특성이라 할 수 있다. 또한 백성들은 살아가면서 “천지간 만물 중에 사람밖에 또 있는가.” 라고 읊조림으로서 인간의 존엄을 고조시켜왔다. 이와 같이 한국문화의 핵심적 가치를 人本思想에서 찾을 서양인들이 “조선인들의 특성은 조선인들을 현대문명의 이기주의로 인하여 침해된 다른 나라 국민들의 훨씬 위에 서게 하는 소이가 된다.”고 보는 점도 한국문화를 人本思想으로 이해하는 데 일조한다. 자연을 대상으로 삼는 우리의 전통적 풍수관에서도 한국인이 강력한 인간 존중의 사고를 엿볼 <단군신화>에서 알 있듯이 ‘널리 사람들을 유익하게 해준다’는 人本思想的 ‘태백산 신단수 밑’이라는風水的 길지 선택으로 구현하고자 했던 의도는 시사하는 바가 크다. 일반적으로 언급되는 풍수 구성의 3요소(산, 물, 방위)에 한국의 관련서들에서, ‘사람(인심)’을 추가 또는 강조하는 것도...