Angela Hadjipanayis
A5086670196- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Chromatin Remodeling and Cancer
- Viral Infections and Outbreaks Research
- Bacillus and Francisella bacterial research
- Cancer, Hypoxia, and Metabolism
- Ovarian cancer diagnosis and treatment
- Genomics and Rare Diseases
- PI3K/AKT/mTOR signaling in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Prostate Cancer Treatment and Research
- Diet and metabolism studies
- Immunotherapy and Immune Responses
- Renal cell carcinoma treatment
- Metabolism, Diabetes, and Cancer
- Chemokine receptors and signaling
- BRCA gene mutations in cancer
- Endometrial and Cervical Cancer Treatments
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
Sanofi (United States)
2023-2025
AVEO Oncology (United States)
2024
Brigham and Women's Hospital
2011-2022
Pfizer (United States)
2019-2022
Harvard University
2010-2022
Harvard University Press
2013-2015
National Institutes of Health
2014-2015
University of North Carolina at Chapel Hill
2014
University of Michigan
2014
Emory University
2014
We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- sequencing-based technologies. Uterine serous tumours ∼25% high-grade endometrioid had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, frequent TP53 mutations. Most alterations or mutations, but mutations in PTEN, CTNNB1, PIK3CA, ARID1A KRAS novel the SWI/SNF chromatin remodelling complex gene ARID5B....
The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations the oncogene PIK3CA, novel alterations involving loss TRAF3, amplification cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 CDKN2A inactivation with frequent copy number including 3q26/28 11q13/22. A...
<h2>Summary</h2> Papillary thyroid carcinoma (PTC) is the most common type of cancer. Here, we describe genomic landscape 496 PTCs. We observed a low frequency somatic alterations (relative to other carcinomas) and extended set known PTC driver include <i>EIF1AX</i>, <i>PPM1D</i>, <i>CHEK2</i> diverse gene fusions. These discoveries reduced fraction cases with unknown oncogenic from 25% 3.5%. Combined analyses variants, expression, methylation demonstrated that different groups lead...
Significance A significant proportion of head and neck cancer is driven by human papillomavirus (HPV) infection, the expression viral oncogenes involved in development these tumors. However, role HPV integration primary tumors beyond increasing oncoproteins not understood. Here, we describe how impacts host genome amplification disruption tumor suppressors as well driving inter- intrachromosomal rearrangements. Tumors that do have integrants display distinct gene profiles DNA methylation...
DNA copy number variations (CNVs) play an important role in the pathogenesis and progression of cancer confer susceptibility to a variety human disorders. Array comparative genomic hybridization has been used widely identify CNVs genome wide, but next-generation sequencing technology provides opportunity characterize wide with unprecedented resolution. In this study, we developed algorithm detect from whole-genome data applied it newly sequenced glioblastoma matched control. This read-depth...
Somatic mtDNA mutations have been reported in some human tumors, but their spectrum different malignancies and role cancer development remain incompletely understood. Here, we describe the breadth of somatic inherited across mitochondrial genome by sequence analyses paired tumor normal tissue samples from 226 individuals with five types using whole-genome data generated The Cancer Genome Atlas Research Network. frequencies deleterious tumor-specific found varied types, ranging 13%...
Abstract Lung cancer is the second most frequently diagnosed and leading cause of cancer-related mortality worldwide. Tumour ecosystems feature diverse immune cell types. Myeloid cells, in particular, are prevalent have a well-established role promoting disease. In our study, we profile approximately 900,000 cells from 25 treatment-naive patients with adenocarcinoma squamous-cell carcinoma by single-cell spatial transcriptomics. We note an inverse relationship between anti-inflammatory...
A systematic cataloging of genes affected by genomic rearrangement, using multiple patient cohorts and cancer types, can provide insight into cancer-relevant alterations outside exomes. By integrative analysis whole-genome sequencing (predominantly low pass) gene expression data from 1,448 cancers involving 18 histopathological types in The Cancer Genome Atlas, we identified hundreds for which the nearby presence (within 100 kb) a somatic structural variant (SV) breakpoint is associated with...
Genomic rearrangements exert a heavy influence on the molecular landscape of cancer. New analytical approaches integrating somatic structural variants (SSVs) with altered gene features represent framework by which we can assign global significance to core set genes, analogous established methods that identify genes non-randomly targeted mutation or copy number alteration. While recent studies have defined broad patterns association involving transcription and nearby SSV breakpoints,...
Objective Neutrophils are typically the most abundant leucocyte in arthritic synovial fluid. We sought to understand changes that occur neutrophils as they migrate from blood joint. Methods performed RNA sequencing of healthy human blood, and fluid, comparing transcriptional signatures with those murine K/BxN serum transfer arthritis. employed mass cytometry quantify protein expression reproduce fluid phenotype ex vivo cultured neutrophils. Results Blood donors patients active arthritis...
Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed better understand how enhancing BCAA catabolism affected metabolic homeostasis as well the mechanisms underlying these improvements. The rate limiting step is irreversible decarboxylation by branched ketoacid dehydrogenase (BCKDH) enzyme complex, which post-translationally controlled through phosphorylation BCKDH kinase (BDK). study utilized BT2, a small molecule...
Fusion genes represent a class of attractive therapeutic targets. Thousands fusion have been identified in patients with cancer, but the functional consequences and implications most these remain largely unknown. Here, we develop genomic approach that consists efficient reconstruction sensitive cell viability drug response assays. Applying this approach, characterize ~100 detected patient samples The Cancer Genome Atlas, revealing notable fraction low-frequency fusions activating effects on...
Abstract Mechanism of action studies are imperative for translating oncology therapeutics into the clinic informing testable hypotheses and potential combination partners. One class therapeutics, immune-stimulatory cytokines can augment antitumor efficacy checkpoint blockade, but further translational work is required to understand beneficial treatment effects versus unwanted immunotoxicities. SAR445877 (SAR’877, formerly KD050), a novel antibody-cytokine fusion protein consisting an Fc...
Abstract CAR T-cells have set a new standard of clinical activity in patients with hematologic malignancies but there are several barriers to broader patient access. Currently, the genetic modification patients' T cells produce CAR-T cell therapies is carried out ex vivo before infusing back into patient, using methods that complex and hinder widespread use. Here we share targeted lipid nanoparticle (LNP) encapsulating mRNA reprogram circulating human vivo, designed overcome significant...
Abstract Metabolic reprogramming plays a central role in T cell activation and differentiation, the inhibition of key metabolic pathways activated cells represents logical approach for development new therapeutic agents treating autoimmune diseases. The widely prescribed antidiabetic drug metformin glycolytic inhibitor 2-deoxyglucose (2-DG) have been used to study oxidative phosphorylation glycolysis, respectively, murine immune cells. Published studies demonstrated that combination...
ABSTRACT Anthrax, a disease usually associated with herbivores, is caused by the bacterium Bacillus anthracis . The current vaccine licensed for human use requires six-dose primary series and yearly boosters causes reactogenicity in up to 30% of recipients. A minimally reactogenic requiring fewer inoculations warranted. Venezuelan equine encephalitis (VEE) virus has been configured as vector wide variety immunogens. VEE composed self-replicating RNA (replicon) containing all nonstructural...
Facioscapulohumeral muscular dystrophy (FSHD) is caused by misexpression of the DUX4 transcription factor in skeletal muscle that results transcriptional alterations, abnormal phenotypes and cell death. To gain insight into kinetics DUX4-induced stresses, we activated expression myoblasts performed longitudinal RNA sequencing paired with proteomics phosphoproteomics. This analysis revealed changes cellular physiology upon activation, including DNA damage altered mRNA splicing....