Eric Burks
A5016344156- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Urological Disorders and Treatments
- Genital Health and Disease
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- Cardiac tumors and thrombi
- AI in cancer detection
- Sarcoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Urologic and reproductive health conditions
- Renal and related cancers
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- IgG4-Related and Inflammatory Diseases
- Renal cell carcinoma treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Urinary and Genital Oncology Studies
- Cervical Cancer and HPV Research
- Gene expression and cancer classification
Boston University
2020-2025
Boston Medical Center
2019-2024
Lahey Hospital and Medical Center
2012-2024
Universidad Libre de Colombia
2022
University of Minnesota Rochester
2022
Gangneung Asan Hospital
2022
MSD K.K. (Japan)
2021-2022
Novartis (Switzerland)
2022
American Society for Radiation Oncology
2022
Jazz Pharmaceuticals (United States)
2022
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization 110 tumors 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, acetylproteomics. Multi-omics clustering revealed four subgroups defined by key driver mutations, country, gender. Proteomic phosphoproteomic data illuminated downstream copy number aberrations, somatic...
Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few therapeutic options. We characterized the proteogenomic landscape LSCC, providing deeper exposition LSCC biology potential implications. identify NSD3 as an alternative driver in FGFR1-amplified tumors and low-p63 overexpressing target survivin. SOX2 is considered undruggable, but our analyses provide rationale for exploring chromatin modifiers such LSD1 EZH2 to SOX2-overexpressing tumors. Our data support...
Deep learning is a powerful tool for whole slide image (WSI) analysis. Typically, when performing supervised deep learning, WSI divided into small patches, trained and the outcomes are aggregated to estimate disease grade. However, patch-based methods introduce label noise during training by assuming that each patch independent with same as neglect overall WSI-level information significant in grading. Here we present Graph-Transformer (GT) fuses graph-based representation of an vision...
Abstract Objectives A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features cytokine storm. However, clinicopathologic diagnostic hemophagocytic lymphohistiocytosis (HLH) have not been reported. We studied the reticuloendothelial organs 4 consecutive who died COVID-19 and correlated with laboratory parameters to detect HLH. Methods Autopsies were performed on COVID-19. Routine H&E staining immunohistochemical for CD163 hemophagocytosis. Clinical results from...
Despite achieving a hematologic complete response after treatment, many patients with AL amyloidosis do not attain recovery of organ function and/or experience relapse. A persistent plasma cell clone producing amyloidogenic light chains at levels below the detection threshold traditional serologic methods is hypothesized to impede in some patients. Assessment minimal residual disease (MRD) may therefore have clinical importance as more stringent treatment tool for response. We used 2-tube,...
SARS-CoV-2 infection disturbs the coagulation balance in blood, triggering thrombosis and contributing to organ failure. The role of prothrombotic metabolites COVID-19-associated coagulopathy remains elusive. Leveraging K18-hACE2 mice infected with SARS-CoV-2, we observed higher levels tryptophan metabolite, kynurenine, compared controls. SARS CoV-2 showed a significant upregulation enzymes controlling Kynurenine biogenesis, such as indoleamine 2,3-dioxygenase (IDO-1) kidneys liver,...
ABSTRACT The molecular drivers bronchial premalignant lesion progression to invasive lung squamous cell carcinoma are not well defined. Prior work profiling longitudinally collected biopsies by RNA sequencing defined a proliferative subtype, enriched with dysplasia. We found that gene co-expression module associated interferon gamma signaling and antigen processing/presentation was down-regulated in progressive/persistent versus regressive lesions within the suggesting functional impact of...
CD4(+) CD56(+) lineage-negative malignancies are difficult to diagnose and classify. Recent studies have suggested that these may derive from plasmacytoid dendritic cells (pDC). In this report, we examine 10 cases of CD4+, CD56+ presented in various tissue sites. The goal was identify the morphologic, immunophenotypic, genotypic findings devise a diagnostic approach biopsies lesions confirm proposed cell origin. mean age 66 years (range, 45-80 years) with male predominance (8 males/2...
Inflammatory myofibroblastic tumors (IMT) of the uterus may be underrecognized as their morphology and immunophenotype overlap with myxoid variants uterine smooth muscle endometrial stromal tumors. Although ALK is a helpful biomarker, not all IMTs are -rearranged, small subset leiomyosarcomas ALK-positive. Herein, we evaluated series 23 for novel markers interferon-inducible transmembrane protein-1 (IFITM1) BCOR, myoid marker transgelin, possible predictive p16 p53 by immunohistochemistry to...
Objective To identify micro RNA (mi ) characteristic of metastatic clear cell renal carcinoma (cc RCC and those indicative cancer‐specific survival ( CSS in nephrectomy biopsy specimens. We also sought to determine if a mi panel could differentiate benign from cc tissue. Materials Methods was isolated kidney specimens n = 156 46, respectively). Samples were grouped: benign, non‐progressive, progressive . Mi s profiled by microarray validated quantitative reverse transcription‐polymerase...
The most severe and fatal infections with SARS-CoV-2 result in the acute respiratory distress syndrome, a clinical phenotype of coronavirus disease 2019 (COVID-19) that is associated virions targeting epithelium distal lung, particularly facultative progenitors this tissue, alveolar epithelial type 2 cells (AT2s). Little known about initial responses human lung alveoli to infection due part inability access these from patients, at early stages disease. Here we present an vitro model...
Abstract Background A subset of COVID-19 patients exhibit clinical features cytokine storm. However, clinicopathologic diagnostic hemophagocytic lymphohistiocytosis (HLH) have not been reported. Pathologic studies to date largely focused on the pulmonary finding diffuse alveolar damage (DAD). To this aim, we study reticuloendothelial organs four consecutive dying and correlate with laboratory parameters detect HLH. Methods Autopsies restricted chest abdomen were performed who succumbed...
Recent randomized control trials (JCOG0802 and CALGB140503) have shown sublobar resection to be noninferior lobectomy for non-small cell lung cancer (NSCLC) ≤2.0 cm. We previously proposed histologic criteria stratifying adenocarcinoma into indolent low malignant potential (LMP) aggressive angioinvasive adenocarcinomas, resulting in better prognostication than provided by World Health Organization grade. Here we determine whether pathologic classification is reproducible subsets of...
Lung cancer screening has improved mortality among high-risk smokers but coincidentally detected a fraction of nonprogressive adenocarcinoma historically classified as bronchoalveolar carcinoma (BAC). In the National Screening Trial (NLST) majority BAC—comprising 29% computed tomography–detected stage I lung adenocarcinoma—were considered overdiagnosis after extended follow-up comparison with control arm. current classification, in situ and minimally invasive have replaced BAC together...