Bettina F. Drake
A5086948636- Global Cancer Incidence and Screening
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Ethics in Clinical Research
- Cancer, Lipids, and Metabolism
- Vitamin D Research Studies
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
- Health Policy Implementation Science
- Metabolism, Diabetes, and Cancer
- Genetic Associations and Epidemiology
- Economic and Financial Impacts of Cancer
- Patient-Provider Communication in Healthcare
- Cancer-related molecular mechanisms research
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- BRCA gene mutations in cancer
- Health Systems, Economic Evaluations, Quality of Life
- Ferroptosis and cancer prognosis
- Nutritional Studies and Diet
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
- Biomedical Ethics and Regulation
Washington University in St. Louis
2016-2025
Alvin J. Siteman Cancer Center
2016-2025
Jewish Hospital
2022-2024
Barnes-Jewish Hospital
2022-2024
St. Louis VA Medical Center
2023
Exelixis (United States)
2023
Bristol-Myers Squibb (Germany)
2023
Northwestern University
2023
Roswell Park Comprehensive Cancer Center
2022
University of South Carolina
2013-2022
Blacks have significantly higher rates of hypertension than whites, and lower circulating levels 25-hydroxyvitamin D. There are few data about the effect vitamin D3 (cholecalciferol) supplementation on blood pressure in blacks. During 2 winters from 2008 to 2010, 283 blacks (median age, 51 years) were randomized into a 4-arm, double-blind trial for 3 months placebo, 1000, 2000, or 4000 international units cholecalciferol per day. At baseline, months, 6 systolic diastolic D measured. The...
The NCCN Guidelines for Prostate Cancer Early Detection provide recommendations individuals with a prostate who opt to participate in an early detection program after receiving the appropriate counseling on pros and cons. These Insights summary of recent updates regard testing protocol, use multiparametric MRI, management negative biopsy results optimize clinically significant cancer minimize indolent disease.
A rare African ancestry-specific germline deletion variant in HOXB13 (X285K, rs77179853) was recently reported Martinican men with early-onset prostate cancer. Given the role of variation cancer, we investigated association between X285K and cancer risk a large sample 22 361 ancestry men, including 11 688 cases. The allele present only West ancestry, an frequency that ranged from 0.40% Ghana 0.31% Nigeria to 0% Uganda South Africa, range frequencies admixed North America Europe (0-0.26%)....
African Americans have a disproportionate burden of inflammation-associated chronic diseases such as cancer and lower circulating levels 25-hydroxyvitamin D [25(OH)D]. The effect vitamin D3 (cholecalciferol) supplementation on inflammatory markers is uncertain. We conducted randomized, double-blind, placebo-controlled trial supplemental oral (placebo, 1,000, 2,000, or 4,000 IU/day orally for 3 months) in 328 (median age, 51 years) public housing communities Boston, MA, who were enrolled over...
Background: Risk perceptions are legitimate targets for behavioral interventions because they can motivate medical decisions and health behaviors. However, some survey respondents may not know (or indicate) their risk perceptions. The scope of “don’t know” (DK) responding is unknown. Objective: Examine the prevalence correlates DK to items assessing perceived colorectal cancer. Methods: Two nationally representative, population-based, cross-sectional surveys (2005 National Health Interview...
Although the importance of community engagement in research has been previously established, there are few evidence‐based approaches for measuring level projects. A quantitative measure was developed, aligned with 11 principles (EPs) established literature. The 96 Likert response items; 3–5 quality items and quantity each EP. Cronbach's alpha is used to examine internal consistency that a single Every EP item group had > .85, which indicates strong all question groups across both scales...
Although men of African ancestry have a high risk prostate cancer (PCa), no genes or mutations been identified that contribute to familial clustering PCa in this population. We investigated whether the ancestry–specific variant at 8q24, rs72725854, is enriched with family history 9052 cases, 143 cases from high-risk families, and 8595 controls ancestry. found allele be significantly associated earlier age diagnosis, more aggressive disease, (32% carried vs 23% without 12% controls). For two...
Abstract Background Comorbid diseases influence patient outcomes, yet little is known about how comorbidities interact with treatments for metastatic castrate-resistant prostate cancer (mCRPC). No head-to-head trials have compared the efficacy of abiraterone and enzalutamide - oral androgen-receptor targeted agents (ARTAs) mCRPC. In patients comorbid disease, outcomes ARTAs may differ due to disparate mechanisms action, adverse events, drug interactions. Methods Retrospective observational...
The COVID-19 pandemic involved business closures (e.g., gyms), social distancing policies, and prolonged stressful situations that may have impacted engagement in health behaviors. Our study assessed changes cancer-related behaviors during the pandemic, specifically physical activity, fruit/vegetable intake, smoking/tobacco use, alcohol consumption. Eight cancer centers administered mailed/web-based/telephone surveys between June 2020 March 2021. Surveys demographics, perceptions on...
Purpose: The aim of this study was to explore the African American prostate cancer survivorship experience following radical prostatectomy and factors contributing quality life during survival. Design: men who were part a larger cohort invited participate in focus group. Eighteen open-ended questions designed by team an experienced moderator elicit participants' experiences. Results: Twelve consented study. Emergent themes included views community, perceptions normalcy, emotional side...
Abstract Polygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46) showed reduced performance men African genetic ancestry. We used a cross‐validated search to identify single nucleotide polymorphisms (SNPs) that might improve this population. Anonymized genotypic data were obtained from the PRACTICAL consortium for 6253 Ten iterations 10‐fold cross‐validation conducted select SNPs would be included final...
Community Networks Program (CNP) centers are required to use a community-based participatory research (CBPR) approach within their specific priority communities. Not all communities the same and unique contextual factors collaborators' priorities shape each CBPR partnership. There also established community engagement (CE) principles shown lead quality in any community. However, operationalizing assessing partnership outcomes understand conditions processes that achieving program project...
African American men experience a disproportionate burden of prostate cancer (CaP) morbidity and mortality. National screening guidelines advise to make individualized decisions through process termed informed decision making (IDM). In this pilot study, computer-tailored decision-aid designed promote IDM was evaluated using pre-/posttest design. aged 40 years older were recruited from variety community settings (n = 108). At pretest, 43% reported having made decision; at posttest 47% be the...
Breast cancer screening combined with follow-up and treatment reduces breast mortality. However, in the study clinic, only 12 % of eligible women ≥40 years received a mammogram previous year. The objective this project was to implement patient navigation, our partner health clinic (1) identify overdue for mammogram; (2) increase mammography utilization population over 2-year period. Women were identified. One navigator made navigation attempts period (2009–2011). Navigation included working...