A5026563364- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Statistical Methods in Clinical Trials
- Genetic Associations and Epidemiology
- Hormonal and reproductive studies
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Radiopharmaceutical Chemistry and Applications
- Urinary and Genital Oncology Studies
- Health Systems, Economic Evaluations, Quality of Life
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Meat and Animal Product Quality
- Nutritional Studies and Diet
- Colorectal Cancer Screening and Detection
- Bone health and treatments
- Renal and related cancers
- Estrogen and related hormone effects
- Multiple and Secondary Primary Cancers
- Selenium in Biological Systems
- Antioxidant Activity and Oxidative Stress
- Digestive system and related health
- Esophageal Cancer Research and Treatment
- Advanced Causal Inference Techniques
Fred Hutch Cancer Center
2016-2025
SWOG Cancer Research Network
2006-2024
Cancer Research And Biostatistics
2007-2024
The University of Texas Health Science Center at San Antonio
2009-2024
Northwestern University
2006-2024
City of Hope
2014-2024
City Of Hope National Medical Center
2014-2024
Data Management (Italy)
2024
Stanford University
2024
The University of Texas Southwestern Medical Center
2024
Background. Frailty is considered highly prevalent in old age and to confer high risk for falls, disability, hospitalization, mortality. has been synonymous with comorbidity, other characteristics, but it recognized that may have a biologic basis be distinct clinical syndrome. A standardized definition not yet established.
Mitoxantrone-based chemotherapy palliates pain without extending survival in men with progressive androgen-independent prostate cancer. We compared docetaxel plus estramustine mitoxantrone prednisone metastatic, hormone-independent cancer.We randomly assigned 770 to one of two treatments, each given 21-day cycles: 280 mg three times daily on days 1 through 5, 60 per square meter body-surface area day 2, and dexamethasone divided doses before docetaxel, or 12 5 twice daily. The primary end...
Despite aggressive local therapy, patients with locally advanced bladder cancer are at significant risk for metastases. We evaluated the ability of neoadjuvant chemotherapy to improve outcome in who were treated radical cystectomy.Patients enrolled if they had muscle-invasive (stage T2 T4a) and be cystectomy. They stratified according age (less than 65 years vs. or older) stage (superficial muscle invasion more extensive disease) randomly assigned cystectomy alone three cycles methotrexate,...
The optimal upper limit of the normal range for prostate-specific antigen (PSA) is unknown. We investigated prevalence prostate cancer among men in Prostate Cancer Prevention Trial who had a PSA level 4.0 ng per milliliter or less.Of 18,882 enrolled prevention trial, 9459 were randomly assigned to receive placebo and an annual measurement digital rectal examination. Among these men, 2950 never more than abnormal examination, final determination, underwent biopsy after being study seven...
<h3>Context</h3>The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk prostate cancer with either selenium or vitamin supplements but a statistically nonsignificant increase E. Longer follow-up more events provide further insight into relationship cancer.<h3>Objective</h3>To determine long-term effect on relatively healthy men.<h3>Design, Setting, Participants</h3>A total 35 533 men from 427 study sites United States, Canada, Puerto Rico...
Extraprostatic disease will be manifest in a third of men after radical prostatectomy. We present the long-term followup randomized clinical trial radiotherapy to reduce risk subsequent metastatic and death.A total 431 with pT3N0M0 prostate cancer were 60 64 Gy adjuvant or observation. The primary study end point was metastasis-free survival.Of 425 eligible 211 observation 214 radiation. Of those under 70 ultimately received radiotherapy. Metastasis-free survival significantly greater (93...
You have accessJournal of UrologyAdult urology1 Jun 2007Guideline for the Management Clinically Localized Prostate Cancer: 2007 Updateis accompanied byQuantifying Impact Volumes, Number Biopsy Cores and 5α-Reductase Inhibitor Therapy on Probability Cancer Detection Using Mathematical Modeling Ian Thompson, James Brantley Thrasher, Gunnar Aus, Arthur L. Burnett, Edith D. Canby-Hagino, Michael S. Cookson, Anthony V. D’Amico, Roger R. Dmochowski, David T. Eton, Jeffrey Forman, Larry Goldenberg,...
Background: Prostate-specific antigen (PSA) testing is the primary method used to diagnose prostate cancer in United States. Methods integrate other risk factors associated with into individualized prediction are needed. We biopsy data from men who participated Prostate Cancer Prevention Trial (PCPT) develop a predictive model of cancer. Methods: included 5519 placebo group PCPT underwent biopsy, had at least one PSA measurement and digital rectal examination (DRE) performed during year...
ContextDespite a stage-shift to earlier cancer stages and lower tumor volumes for prostate cancer, pathologically advanced disease is detected at radical prostatectomy in 38% 52% of patients. However, the optimal management these patients after unknown.ObjectiveTo determine whether adjuvant radiotherapy improves metastasis-free survival with stage pT3 N0 M0 cancer.Design, Setting, PatientsRandomized, prospective, multi-institutional, US clinical trial enrollment between August 15, 1988,...
The risk factors for cardiovascular disease and erectile dysfunction are similar.To examine the association of subsequent disease.Men aged 55 years or older who were randomized to placebo group (n = 9457) in Prostate Cancer Prevention Trial at 221 US centers evaluated every 3 months between 1994 2003. Proportional hazards regression models used evaluate disease. In an adjusted model, covariates included age, body mass index, blood pressure, serum lipids, diabetes, family history myocardial...
Background —Several epidemiological studies have associated depressive symptoms with cardiovascular disease. We investigated whether constituted a risk for coronary heart disease (CHD) and total mortality among an apparently healthy elderly cohort. Methods Results —In prospective cohort of 5888 Americans (≥65 years) who were enrolled in the Cardiovascular Health Study, 4493 participants free at baseline provided annual information on their status, which was assessed using Depression Scale...
Castration resistance occurs in most patients with metastatic hormone-sensitive prostate cancer who are receiving androgen-deprivation therapy. Replacing androgens before progression of the disease is hypothesized to prolong androgen dependence.
To establish whether absolute prostate-specific antigen (PSA) value after androgen deprivation (AD) is prognostic in metastatic (D2) prostate cancer (PCa).D2 PCa patients with baseline PSA of at least 5 ng/mL received 7 months induction AD. Patients achieving 4.0 or less on 6 and are randomly assigned to continuous versus intermittent AD month 8. Eligibility for this analysis required a prestudy two subsequent PSAs that be registered 1 year before date. Survival was defined as time death...
Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank GWA consortia, we found that a one standard deviation increment average acceleration was (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) (OR: 0.66, CI: 0.48 0.90, 0.01)....
In the Prostate Cancer Prevention Trial (PCPT), men receiving finasteride had a 24.8% lower risk of prostate cancer than placebo but higher high-grade cancer. We examined impact on sensitivity and area under receiver operating characteristic curve (AUC) prostate-specific antigen (PSA) for detecting cancer.We studied in groups PCPT who biopsy concurrent PSA tests during 7-year study. compared AUC detection all cancer, Gleason grade 7 or 8 All statistical were two-sided.Of 5112 group, was...
Circulating tumor cell (CTC) enumeration has not been prospectively validated in standard first-line docetaxel treatment for metastatic castration-resistant prostate cancer. We assessed the prognostic value of CTCs overall survival (OS) and disease response S0421, a phase III trial plus prednisone with or without atrasentan.CTCs were enumerated at baseline (day 0) before cycle two 21) using CellSearch. Baseline counts changes from day 0 to 21 evaluated association OS, prostate-specific...
In the Prostate Cancer Prevention Trial (PCPT), finasteride significantly reduced risk of prostate cancer but was associated with an increased high-grade disease. With up to 18 years follow-up, we analyzed rates survival among all study participants and those cancer.We collected data on incidence PCPT for additional year after our first report published in 2003 searched Social Security Death Index assess status through October 31, 2011.Among 18,880 eligible men who underwent randomization,...
The Selenium and Vitamin E Cancer Prevention Trial found no effect of selenium supplementation on prostate cancer (PCa) risk but a 17% increased from vitamin supplementation. This case–cohort study investigates effects conditional upon baseline status. There were 1739 total 489 high-grade (Gleason 7–10) PCa cases 3117 men in the randomly selected cohort. Proportional hazards models estimated hazard ratios (HRs) 95% confidence intervals (CIs) for within quintiles toenail selenium. Cox...