Andrea Gsur
A5015479782- Genetic factors in colorectal cancer
- Genetic Associations and Epidemiology
- Fibroblast Growth Factor Research
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Epigenetics and DNA Methylation
- Digestive system and related health
- Nutrition, Genetics, and Disease
- Sexual Differentiation and Disorders
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Folate and B Vitamins Research
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- DNA Repair Mechanisms
- Acute Myeloid Leukemia Research
- Glutathione Transferases and Polymorphisms
Medical University of Vienna
2016-2025
Comprehensive Cancer Center Vienna
2011-2025
Institute of Cancer Research
2005-2023
Center for Cancer Research
2023
University of Vienna
1995-2022
Imperial College London
2021
Broad Institute
2021
Massachusetts General Hospital
2021
Harvard University
2021
Huntsman Cancer Institute
2019
Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank GWA consortia, we found that a one standard deviation increment average acceleration was (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) (OR: 0.66, CI: 0.48 0.90, 0.01)....
Abstract Background Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery additional susceptibility may capture unexplained familial risk. Methods We conducted a GWAS in European descent CRC cases and control subjects using discovery–replication design, followed by examination novel findings multiethnic sample (cumulative n = 163 315). In stage (36 948...
Abstract Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or sex is unclear. Further, metabolic alterations mediating effects on CRC are not fully understood. Methods We examined sex- and site-specific associations with adiposity-associated metabolites explain CRC. Genetic variants from genome-wide association studies body mass index (BMI) waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), 123...
Background & AimsHuman studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and binding protein 3 (IGFBP3) colorectal cancer risk have reported inconsistent results. We conducted complementary serologic Mendelian randomization (MR) analyses to determine whether alterations in IGF1 or IGFBP3 are associated with development.MethodsSerum were measured blood samples collected from 397,380 participants the UK Biobank, 2006 through 2010. Incident cases...
Epidemiological studies have linked lifestyle, cardiometabolic, reproductive, developmental, and inflammatory factors to the risk of colorectal cancer. However, which specific affect strength these effects are unknown. We aimed examine relationship between potentially modifiable
Diverticular disease is a common complex disorder characterised by mucosal outpouchings of the colonic wall that manifests through complications such as diverticulitis, perforation and bleeding. We report to date largest genome-wide association study (GWAS) identify genetic risk factors for diverticular disease.Discovery GWAS analysis was performed on UK Biobank imputed genotypes using 31 964 cases 419 135 controls European descent. Associations were replicated in sample 3893 2829...
Disease-specific alterations of the cell-free DNA methylation status are frequently found in serum samples and currently considered to be suitable biomarkers. Candidate markers were identified by bisulfite conversion-based genome-wide screening lung tissue from cancer, fibrotic ILD, COPD. cfDNA 400 μl (n = 204) served test diagnostic performance these markers. Following methylation-sensitive restriction enzyme digestion enrichment methylated via targeted amplification (multiplexed MSRE...
Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the existing knowledge CRC. We identify PRKCI, SPZ1, MUTYH, MAP2K4, FETUB, and TGFBR2 as additional significantly mutated find that among hypermutated tumors, an increased mutation burden associated improved CRC-specific (HR = 0.42, 95% CI:...
Background Epidemiological studies have reported conflicting findings on the potential adverse effects of long-term antihypertensive medication use cancer risk. Naturally occurring variation in genes encoding drug targets can be used as proxies for these to examine effect their therapeutic inhibition disease outcomes. Methods and We performed a mendelian randomization analysis association between genetically proxied 3 risk 4 common cancers (breast, colorectal, lung, prostate)....
Abstract Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases 154,587 controls of East Asian European ancestry. Our stepwise conditional analyses revealed 238 independent signals each a set credible (CCVs), which 28 had single CCV. cis-eQTL/mQTL colocalization...
CYP17 encodes the enzyme cytochrome P-450c17 alpha, which mediates both 17 alpha-hydroxylase and 17,20-lyase in steroid biosynthesis pathway. A polymorphism 5; promoter region of gene has been described. Steroid hormones, especially androgens, are believed to play a key role etiology prostate cancer. Therefore, polymorphisms genes involved androgen metabolism may affect risk We conducted case-control study 63 patients with untreated histologically proven cancer 126 age-matched control men...
Several polymorphic glutathione-S-transferase (GST) enzymes are involved in the metabolism of a number potential prostate carcinogens and thought to engage transport steroid hormones. A case-control study was conducted determine association GSTP1, GSTM1 GSTT1 polymorphisms prostate-cancer risk. The population consisted 166 patients with previously untreated, histologically proven cancer age-matched control benign prostatic hyperplasia (BPH), all them Caucasians. In GSTP1 gene, 2 alleles,...
Colorectal cancer is known to arise from multiple tumorigenic pathways; however, the underlying mechanisms remain not completely understood. Metabolomics becoming an increasingly popular tool in assessing biological processes. Previous metabolomics research focusing on colorectal limited by sample size and did replicate findings independent study populations verify robustness of reported findings. Here, we performed a ultrahigh performance liquid chromatography‐quadrupole time‐of‐flight mass...