A5100454664- COVID-19 epidemiological studies
- Advanced Combinatorial Mathematics
- Folate and B Vitamins Research
- SARS-CoV-2 and COVID-19 Research
- Health and Wellbeing Research
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Nutritional Studies and Diet
- Vaccine Coverage and Hesitancy
- Advanced Mathematical Identities
- Health disparities and outcomes
- Nutrition and Health in Aging
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- COVID-19 Clinical Research Studies
- Random Matrices and Applications
- Nutrition, Health and Food Behavior
- Education, Safety, and Science Studies
- COVID-19 Pandemic Impacts
- Esophageal and GI Pathology
- Suicide and Self-Harm Studies
- Stochastic processes and statistical mechanics
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
Hallym University
2014-2024
International Vaccine Institute
2023-2024
Seoul National University
2023
Korea Disease Control and Prevention Agency
2022
Inha University
2021
Georgia State University
2021
University of California, Berkeley
2021
Kangdong Sacred Heart Hospital
2016
North Carolina Central University
2015
Woosong University
2015
Abstract Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases 154,587 controls of East Asian European ancestry. Our stepwise conditional analyses revealed 238 independent signals each a set credible (CCVs), which 28 had single CCV. cis-eQTL/mQTL colocalization...
Abstract High-density lipoprotein cholesterol (HDL-C) has been suggested to be associated with breast cancer. However, the roles of HDL-C and hypertriglyceridemia on cancer still have controversial. The goal this study was investigate association between risk, stratifying by menopausal status, body mass index. hormonal receptor status proposed modify effect Multicenter hospital-based case-control conducted from November 2004 December 2005 in Korea. After one two individual matchings age (±5...
Objectives This study estimated the association of cardiovascular health behaviors with risk all-cause and disease (CVD) mortality in middle-aged men Korea. Methods In total, 12 538 aged 40 to 59 years were enrolled 1993 followed up through 2011. Cardiovascular metrics defined following lifestyle proposed by American Heart Association: smoking, physical activity, body mass index, diet habit score, total cholesterol, blood pressure, fasting glucose. The score was calculated as a single...
Abstract Background Body composition changes with ageing can influence the adiponectin concentration. However, component of body that is associated concentrations in older adults remains unclear. Methods There were 152 males and 168 females aged 65 years or participated 2010 Hallym Aging Study (HAS). (assessed by dual energy X-ray absorptiometry; DXA), anthropometric parameters obtained from all participants. Multivariate linear regression models assessed association fat percentage, regional...
Previous studies reported mixed results regarding the association between cognition and body weight in late life. We evaluated relationships cognitive function composition among community-dwelling older adults.Three hundred twenty subjects (≥65 years, women 53%) with available data of from 2010 Hallym Aging Study. Cognitive was assessed using Korean Mini-Mental State Examination (K-MMSE). Dual-energy X-ray absorptiometry (DEXA) used for measuring including fat lean mass. Anthropometric...
Abstract Background To investigate the frequency of pain among subjects with advanced radiographic knee osteoarthritis (OA) defined as Kellgren–Lawrence (KL) grade 4 and clinical features associated pain. Methods Subjects from Hallym Aging Study (HAS), Korean National Health Nutrition Examination Survey (KNHANES), Osteoarthritis Initiative (OAI) were included. Participants asked knee-specific questions regarding presence Clinical characteristics evaluated multivariable logistic regression...
This study was conducted to estimate the prevalence of non-suicidal self-injury (NSSI)-the most severe mental health problem among South Korean adolescents in 2019. The participants were students from 12 middle and seven high schools a single city metropolitan area Korea. A cluster-random sampling method used-one class per school year at each schools. Every student selected classes investigated. final number as follows: 36 classes, 1074 schools; 35 873 school. Data obtained using...
This study sought to determine which factors among the indicators of socioeconomic status have most influence on physical, mental and social functions, subjective well-being, all are components successful ageing. A representative random sample 1825 persons aged 65 years or older was surveyed by face-to-face interview. Socioeconomic measured educational level, family household income, personal income property ownership. The were chronic diseases, activities daily living (ADL) for physical...
Many potentially modifiable risk factors for prostate cancer are also associated with screening, which may induce a bias in epidemiologic studies. We investigated the associations of body mass index (weight (kg)/height (m)(2)), smoking, and alcohol consumption fatal Asian countries where screening is not widely utilized. Analysis included 18 prospective cohort studies conducted during 1963-2006 across 6 southern eastern Asia that part Cohort Consortium. Body index, intake were determined by...
Abstract Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher undertake targeted screening. However, current PRS using European ancestry data sub-optimal performance in non-European populations, limiting their utility among these populations. Towards addressing this deficiency, we expand development for CRC incorporating Asian (21,731 cases; 47,444 controls) into training datasets (78,473 107,143 controls). The...
The COVID-19 Vaccine Safety Research Committee (CoVaSC) was established in November 2021 to address the growing need for independent, in-depth scientific evidence on adverse events (AEs) following coronavirus disease 2019 (COVID-19) vaccination. This initiative requested by Korea Disease Control and Prevention Agency led National Academy of Medicine Korea. In September 2022, Center established, strengthening CoVaSC's initiatives. center has conducted various studies safety vaccines. During...
Background Prospective investigation of obesity and renal function decline in Asia is sparse. We examined the associations body mass index (BMI) waist circumference (WC) with a prospective study Korean population. Methods A total 454 participants who had baseline estimated glomerular filtration rate (eGFR) levels more than 60 mL/min/1.73 m2 Hallym Aging Study (HAS) were included followed for 6 years. Renal was defined as follows: (1) an eGFR ≥3 m2/year (n = 82 cases); (2) decrease 20% or...
Abstract Coronavirus disease (COVID-19) has been spreading all over the world; however, its incidence and case-fatality ratio differ greatly between countries continents. We investigated factors associated with international variation in COVID-19 (CFR) across 107 northern hemisphere countries, using publicly available outcome data as of 14 September 2020. included country-specific geographic, demographic, socio-economic features, global health security index (GHSI), healthcare capacity,...
With the introduction of coronavirus disease 2019 (COVID-19) vaccines, Korea Disease Control and Prevention Agency (KDCA) commissioned National Academy Medicine to gather experts independently assess post-vaccination adverse events. Accordingly, COVID-19 Vaccine Safety Research Committee (CoVaSC) was launched in November 2021 perform safety studies establish evidence for policy guidance. The CoVaSC established 3 committees epidemiology, clinical research, communication. mainly utilizes...
The recent Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak has originated from a failure in the national quarantine system Republic of Korea as most basic role protecting safety and lives its citizens. Furthermore, number Korean healthcare system's weaknesses seem to have been completely exposed. MERS-CoV can be considered typical public health crisis that was not only greatly terrorized by actual fear disease, but also experienced great impact their daily lives, all short...