A5056958853- Dementia and Cognitive Impairment Research
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Bone health and osteoporosis research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Adrenal and Paraganglionic Tumors
- Metabolism, Diabetes, and Cancer
- Obesity, Physical Activity, Diet
- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Neurological Disease Mechanisms and Treatments
- Nutritional Studies and Diet
- Regulation of Appetite and Obesity
- Lipoproteins and Cardiovascular Health
- Pituitary Gland Disorders and Treatments
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Vitamin D Research Studies
- Birth, Development, and Health
- Peroxisome Proliferator-Activated Receptors
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
Hallym University
2015-2025
Chuncheon Sacred Heart Hospital
2014-2025
Hallym Polytechnic University
2012-2024
Konyang University
2024
Yeungnam University
2024
Konyang University Hospital
2024
Ajou University
2024
Hallym University Medical Center
2013-2019
Hallym University Kangnam Sacred Heart Hospital
2018-2019
Korea University
2005-2008
Background/Aims Recent epidemiological studies revealed a striking inverse relationship between vitamin D levels, glucose intolerance/insulin resistance (IR), and cardiovascular disease. However, few interventional have evaluated the effect of supplementation on risk, such as IR arterial stiffness, in diabetes. We investigated role risk type 2 diabetes patients, including metabolic parameters, IR, stiffness. Methods enrolled patients who were taking antidiabetic medications or managed their...
Epidemiologic studies have shown that low vitamin D levels are associated with reduced insulin sensitivity and increased risk of developing type 2 diabetes mellitus (T2DM). However, there is little evidence supplementation improves glucose intolerance. We evaluated the glucose-lowering effect in Korean T2DM subjects. enrolled 158 patients who had stable glycemic control [hemoglobin A1c (HbA1c) <8.5%] less than 20 ng/mL. The participants were randomized into two groups: Placebo (100 mg daily...
Abstract Background Metabolic syndrome is a cluster of conditions that occur together, increasing the risk cardiovascular disease. However, relationship between metabolic and dementia has remained controversial. Using nationwide population cohort data, we investigated association dementia, according to type. Methods We analyzed data 84,144 individuals, in aged group more than 60 years, January 1, 2009, December 31, at Gangwon province by using information (Korean) National Health Insurance...
Summary Objective Retinol‐binding protein 4 (RBP4) is a recently identified adipokine that elevated in the serum several insulin‐resistant states. We investigated relationship between non‐alcoholic fatty liver disease (NAFLD) and RBP4 nondiabetic adults. Methods One hundred fifty‐nine nondiabetic, subjects (95 males 64 females) participated this study. Division of into NAFLD group ( n = 73; 45 28 or normal 86; 50 36 was based on presence determined by sonography. Results Serum levels were...
Abstract Background Body composition changes with ageing can influence the adiponectin concentration. However, component of body that is associated concentrations in older adults remains unclear. Methods There were 152 males and 168 females aged 65 years or participated 2010 Hallym Aging Study (HAS). (assessed by dual energy X-ray absorptiometry; DXA), anthropometric parameters obtained from all participants. Multivariate linear regression models assessed association fat percentage, regional...
Previous studies reported mixed results regarding the association between cognition and body weight in late life. We evaluated relationships cognitive function composition among community-dwelling older adults.Three hundred twenty subjects (≥65 years, women 53%) with available data of from 2010 Hallym Aging Study. Cognitive was assessed using Korean Mini-Mental State Examination (K-MMSE). Dual-energy X-ray absorptiometry (DEXA) used for measuring including fat lean mass. Anthropometric...
Summary Objective We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal diabetic patients. Patients measurements The study subjects comprised 49 newly diagnosed patients 72 age‐ sex‐matched glucose controls. Anthropometric parameters, blood pressure, fasting (FBG), lipid profiles, OPG, high‐sensitive C‐reactive protein (hsCRP), interleukin‐6 (IL‐6) brachial‐ankle pulse wave velocity (baPWV) were measured. Results Serum...
Background and Purpose Diabetes is associated with cognitive decline as well the development of dementia. Although mean blood glucose levels are typically used to assess status diabetic patients, variability also involved in manifestation macro- microvascular complications this population. Thus, present study sought determine whether visit-to-visit contributes patients type 2 diabetes. Methods The assessed 68 diabetes using several validated neuropsychological measures. All had no...
This study aimed to assess the effects of sarcopenia and A Body Shape Index (ABSI) on cardiovascular disease (CVD) risk according obesity phenotypes.
BackgroundThe novel sodium-glucose cotransporter-2 (SGLT2) inhibitor enavogliflozin effectively lowers glycosylated hemoglobin levels and body weights without the increased risk of serious adverse events; however, long-term clinical benefits in terms cardiovascular renal outcomes have not been investigated. MethodsThis study is an investigator-initiated, multicenter, randomized, pragmatic, open-label, active-controlled, non-inferiority trial. Eligible participants are adults (aged ≥19 years)...
Background Despite its shortcomings, body mass index (BMI) has traditionally been used to define obesity. Another recently introduced obesity measure, A Body Shape Index (ABSI), focus on abdominal obesity, but applicability remains limited. We analyzed the statistical properties of ABSI and propose a modified ABSI, z-score log-transformed (LBSIZ), improve applicability. also examined sensitivity newly in diagnosing based percentage fat ability predict hypertension impaired health-related...
Background/Aims The aim of this study is to compare Friedewald-estimated and directly measured low density lipoprotein cholesterol (LDL-C) values assess the concordance in guideline risk classification between two methods. Methods data were derived from 2009 2011 Korea National Health Nutrition Examination Survey. We included subjects with triglyceride (TG) levels < 400 mg/dL. Analysis was done for 6,454 who had all lipid panels— total cholesterol, LDL-C, high (HDL-C), TG. Results ranged age...
Pheochromocytoma and paraganglioma (PPGLs) are rare catecholamine-secreting neuroendocrine tumors but can be life-threatening. Although most PPGLs benign, approximately 10% have metastatic potential. Approximately 40% cases reported as harboring germline mutations. Therefore, timely accurate diagnosis of is crucial. For more than 130 years, clinical, molecular, biochemical, radiological, pathological investigations been rapidly advanced in the field PPGLs. However, performing diagnostic...
Diabetic nephropathy (DN) is a serious kidney complication of diabetes, and constitutes the leading cause end-stage renal disease. The earliest clinical evidence DN microalbuminuria, term which refers to appearance small but abnormal amounts albumin in urine. However, screening methods for DN, such as biomarker assays, are yet be developed type 2 DN. In present study, an attempt identify biomarkers initial diagnoses protein profiles human sera collected from 30 microalbuminuric diabetic...
Purpose: Dyslipidemia, hypertension, and diabetes are well-established risk factors for cardiovascular disease (CVD).This study investigated the prevalence management status of these dyslipidemia among Korean adults aged 30 years old older. Materials Methods:The dyslipidemia, were analyzed 12229 subjects (≥30 years) participating in Korea National Health Nutrition Survey 2010-2012.Dyslipidemia was defined according to treatment criteria rather than diagnostic Korea.Therefore,...
The hemoglobin glycation index (HGI) quantifies interindividual variations in glycated (HbA1c) and is associated with diabetic complications metabolic diseases. However, information on the association between HGI non-alcoholic fatty liver disease (NAFLD) healthy subjects limited, particularly Asian populations. This study aimed to investigate NAFLD a Korean cohort.Subjects were stratified quartiles according their level. was diagnosed by hepatic ultrasonography, steatosis index. Multiple...
Background: Conventional diagnostic approaches for adrenal tumors require multi-step processes, including imaging studies and dynamic hormone tests. Therefore, this study aimed to discriminate from a single blood sample based on the combination of liquid chromatography-mass spectrometry (LC-MS) machine learning algorithms in serum profiling steroids.Methods: The LC-MS-based steroid was applied samples obtained patients with nonfunctioning adenoma (NFA, n=73), Cushing’s syndrome (CS, n=30),...