Rebecca D. Jackson
A5105520707- Genetic Associations and Epidemiology
- Bone health and osteoporosis research
- Osteoarthritis Treatment and Mechanisms
- Vitamin D Research Studies
- Lower Extremity Biomechanics and Pathologies
- Estrogen and related hormone effects
- Bone health and treatments
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- Menopause: Health Impacts and Treatments
- Genetic factors in colorectal cancer
- Knee injuries and reconstruction techniques
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Nutrition, Genetics, and Disease
- Total Knee Arthroplasty Outcomes
- Opioid Use Disorder Treatment
- Nutrition and Health in Aging
- Hip and Femur Fractures
- Bone Metabolism and Diseases
- Cancer Risks and Factors
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Epigenetics and DNA Methylation
The Ohio State University
2016-2025
Oklahoma State University Medical Center
2021-2025
Department of Conservation
2023-2024
The Ohio State University Wexner Medical Center
2012-2024
Government of New Zealand
2024
University of Cincinnati
2006-2024
University of Kentucky
2024
Ohio Department of Health
2023
Community Link
2023
University of Edinburgh
2022
ContextDespite decades of accumulated observational evidence, the balance risks and benefits for hormone use in healthy postmenopausal women remains uncertain.ObjectiveTo assess major health most commonly used combined preparation United States.DesignEstrogen plus progestin component Women's Health Initiative, a randomized controlled primary prevention trial (planned duration, 8.5 years) which 16608 aged 50-79 years with an intact uterus at baseline were recruited by 40 US clinical centers...
Postmenopausal women have a greater risk than men of developing Alzheimer disease, but studies the effects estrogen therapy on disease been inconsistent. On July 8, 2002, study drugs, plus progestin, in Women's Health Initiative (WHI) trial were discontinued because certain increased health risks receiving combined hormone therapy.To evaluate effect progestin incidence dementia and mild cognitive impairment compared with placebo.The Memory Study (WHIMS), randomized, double-blind,...
Higher intake of calcium and vitamin D has been associated with a reduced risk colorectal cancer in epidemiologic studies polyp recurrence polyp-prevention trials. However, randomized-trial evidence that supplementation is beneficial the primary prevention lacking.We conducted randomized, double-blind, placebo-controlled trial involving 36,282 postmenopausal women from 40 Women's Health Initiative centers: 18,176 received 500 mg elemental as carbonate 200 IU D3 [corrected] twice daily (1000...
To determine the effects of etidronate (a bisphosphonate that inhibits osteoclast-mediated bone resorption) in treatment postmenopausal osteoporosis, we conducted a prospective, two-year, double-blind, placebo-controlled, multicenter study 429 women who had one to four vertebral compression fractures plus radiographic evidence osteopenia.
The hypothesis that a low-fat dietary pattern can reduce breast cancer risk has existed for decades but never been tested in controlled intervention trial.To assess the effects of undertaking on incidence.A randomized, controlled, primary prevention trial conducted at 40 US clinical centers from 1993 to 2005.A total 48,835 postmenopausal women, aged 50 79 years, without prior cancer, including 18.6% minority race/ethnicity, were enrolled.Women randomly assigned modification group (40% [n =...
Health outcomes from the Women's Initiative Estrogen Plus Progestin and Estrogen-Alone Trials have been reported, but previous publications generally not focused on all-cause cause-specific mortality.
Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity Niemann-Pick C1-like 1 (NPC1L1) protein. However, whether such inhibition reduces risk coronary heart disease is not known. Human mutations that inactivate a gene encoding drug target can mimic action an inhibitory and thus be used to infer potential effects drug.We sequenced exons NPC1L1 in 7364 patients with 14,728 controls without who were European, African, or South Asian ancestry. We...
Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these add existing risk-assessment models is unknown.
Observational studies and polyp recurrence trials are not conclusive regarding the effects of a low-fat dietary pattern on risk colorectal cancer, necessitating primary prevention trial.To evaluate eating cancer in postmenopausal women.The Women's Health Initiative Dietary Modification Trial, randomized controlled trial conducted 48,835 women aged 50 to 79 years recruited between 1993 1998 from 40 clinical centers throughout United States.Participants were randomly assigned modification...
The Women's Health Initiative (WHI) double-blind, placebo-controlled clinical trial randomly assigned 36,282 postmenopausal women in the U.S. to 1,000 mg elemental calcium carbonate plus 400 IU of vitamin D3 daily or placebo, with average intervention period 7.0 years. was designed test whether D supplementation a population which use these supplements widespread would reduce hip fracture, and secondarily, total fracture colorectal cancer. This study further examines health benefits risks...
Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD show pleiotropy; that is, they are also other diseases or traits. This study sought to systematically test if genetic variants for non-CAD diseases/traits associate and undertake a comprehensive analysis the extent pleiotropy all loci. In discovery analyses involving 42,335 cases 78,240 control subjects we tested 29,383 common (minor allele frequency >5%) single...
Abstract Background Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery additional susceptibility may capture unexplained familial risk. Methods We conducted a GWAS in European descent CRC cases and control subjects using discovery–replication design, followed by examination novel findings multiethnic sample (cumulative n = 163 315). In stage (36 948...
The 329,000 hip fractures that annually occur in the United States are associated with high morbidity, mortality, and cost. Identification of those at risk is a step toward prevention.To develop an algorithm to predict 5-year fracture postmenopausal women.A total 93,676 women who participated observational component Women's Health Initiative (WHI), multiethnic longitudinal study, were used predictive based on commonly available clinical features. Selected factors predicted then validated by...