Ganesh Chauhan
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological Disease Mechanisms and Treatments
- Diabetes and associated disorders
- Cerebrovascular and genetic disorders
- Blood Coagulation and Thrombosis Mechanisms
- Folate and B Vitamins Research
- Cardiovascular Disease and Adiposity
- Dementia and Cognitive Impairment Research
- Hormonal Regulation and Hypertension
- Genomic variations and chromosomal abnormalities
- RNA regulation and disease
- Regulation of Appetite and Obesity
- Cancer-related gene regulation
- RNA modifications and cancer
- Health, Environment, Cognitive Aging
- Nuclear Receptors and Signaling
- Diet, Metabolism, and Disease
Institute of Genomics and Integrative Biology
2010-2025
Council of Scientific and Industrial Research
2010-2025
Academy of Scientific and Innovative Research
2025
Rajendra Institute of Medical Sciences
2021-2024
University of Michigan
2023
Inserm
2014-2022
Université de Bordeaux
2014-2022
Bordeaux Population Health
2015-2022
North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences
2021
Indian Institute of Science Bangalore
2017-2021
OBJECTIVE Common variants in PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 genes have been shown to be associated with type 2 diabetes European populations by genome-wide association studies. We studied the of common these eight related traits Indians combining data from two independent case–control RESEARCH DESIGN AND METHODS genotyped single nucleotide polymorphisms (PPARG-rs1801282, KCNJ11-rs5219, TCF7L2-rs7903146, SLC30A8-rs13266634, HHEX-rs1111875, CDKN2A-rs10811661,...
Background— The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings incompletely characterized. To identify novel variants influencing burden, we conducted a meta-analysis multiethnic genome-wide association studies. Methods Results— We included 21 079 middle-aged to elderly individuals from 29 population-based cohorts, who were free dementia stroke European (n=17...
Elevated blood pressure is a major risk factor for cardiovascular disease and has substantial genetic contribution. Genetic variation influencing the potential to identify new pharmacological targets treatment of hypertension. To discover additional novel loci, we used 1000 Genomes Project–based imputation in 150 134 European ancestry individuals sought significant evidence independent replication further 228 245 individuals. We report 6 signals association or near HSPB7 , TNXB LRP12...
Objective Genome‐wide association studies (GWAS) have been successful at identifying associations with stroke and subtypes, but not yet identified any solely small vessel (SVS). SVS comprises one quarter of all ischemic is a major manifestation cerebral disease, the primary cause vascular cognitive impairment. Studies across neurological traits shown that younger‐onset cases an increased genetic burden. We leveraged this burden by performing age‐at‐onset informed GWAS meta‐analysis,...
The genetic contribution to dilated perivascular space (dPVS) burden-an emerging MRI marker of cerebral small vessel disease-is unknown. We measured the heritability dPVS burden and its shared with other markers disease.The study sample comprised 1597 participants from population-based Three City (3C) Dijon Study, brain genome-wide genotyping (mean age, 72.8±4.1 years; 61% women). lacunar infarcts were rated on a semiquantitative scale, whereas an automated algorithm generated white matter...