Deborah Janowitz
A5048233924- Psychosomatic Disorders and Their Treatments
- Genetic Associations and Epidemiology
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Child Abuse and Trauma
- Epigenetics and DNA Methylation
- Child and Adolescent Psychosocial and Emotional Development
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Vitamin D Research Studies
- Dementia and Cognitive Impairment Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Suicide and Self-Harm Studies
- Empathy and Medical Education
- Neurological Disease Mechanisms and Treatments
- Personality Disorders and Psychopathology
- Mental Health Treatment and Access
- Action Observation and Synchronization
- Schizophrenia research and treatment
- Cardiovascular Disease and Adiposity
- Treatment of Major Depression
- Fibromyalgia and Chronic Fatigue Syndrome Research
University of Applied Sciences Stralsund
2021-2025
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2025
Universitätsmedizin Greifswald
2014-2023
Universität Greifswald
2007-2023
Houston Methodist
2018
University of Pennsylvania
2018
German Center for Neurodegenerative Diseases
2018
Methodist Hospital
2018
National Institute on Aging
2018
Inserm
2017
We report genome sequences of 17 inbred strains laboratory mice and identify almost ten times more variants than previously known. use these genomes to explore the phylogenetic history mouse examine functional consequences allele-specific variation on transcript abundance, revealing that at least 12% transcripts show a significant tissue-specific expression bias. By identifying candidate 718 quantitative trait loci we molecular nature their position relative genes vary according effect size...
White matter hyperintensities are associated with increased risk of dementia and cognitive decline. The current study investigates the relationship between white burden patterns brain atrophy ageing Alzheimer’s disease in a large populatison-based sample ( n = 2367) encompassing wide age range (20–90 years), from Study Health Pomerania. We quantified using automated segmentation summarized machine learning methods resulting two indices: SPARE-BA index (capturing age-related atrophy),...
We systematically compared structural imaging patterns of advanced brain aging (ABA) in the general-population, herein defined as significant deviation from typical BA to those found Alzheimer disease (AD). The hypothesis that ABA would show different change with AD was tested via pattern analysis methods. In particular, magnetic resonance images 2705 participants Study Health Pomerania (aged 20-90 years) were analyzed using an index captures atrophy (Spatial Pattern Atrophy for Recognition...
<h3>Objectives</h3> To investigate spatial heterogeneity of white matter lesions or hyperintensities (WMH). <h3>Methods</h3> MRI scans 1,836 participants (median age 52.2 ± 13.16 years) encompassing a wide range (22–84 from the cross-sectional Study Health in Pomerania (Germany) were included as discovery set identifying spatially distinct components WMH using structural covariance approach. Scans 307 73.8 10.2 years, with 747 observations) Baltimore Longitudinal Aging (United States) to...
Abstract Background Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim this study was to examine whether CM severity and type are associated with MDD-related brain alterations, how they interact sex age. Methods Within ENIGMA-MDD network, subtypes using Trauma Questionnaire were assessed structural magnetic resonance imaging data from patients MDD healthy controls analyzed a mega-analysis comprising total 3872 participants aged...
The FKBP5 gene codes for a co-chaperone that regulates glucocorticoid receptor sensitivity and thereby impacts the reactivity of hypothalamic-pituitary-adrenal (HPA)-axis. Evidence suggested subjects exposed to childhood abuse carrying TT genotype single nucleotide polymorphism (SNP) rs1360780 have an increased susceptibility stress-related disorders.The hypothesis abused carriers show changes in gray matter (GM) volumes affect-processing brain areas was investigated. About 1,826 Caucasian...
The size of the human head is highly heritable, but genetic drivers its variation within general population remain unmapped. We perform a genome-wide association study on (N = 80,890) and identify 67 loci, which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, most have widespread effects. Gene set enrichment observed for various cancers p53, Wnt, ErbB signaling pathways. Genes harboring lead enriched macrocephaly syndrome genes (37-fold) high-fidelity...
Alexithymia is perceived as a personality construct involving deficits in the cognitive processing of emotion. Brain areas that process emotions might be structurally altered affected people. Subjects from Study Health Pomerania who underwent whole body magnetic resonance imaging were investigated. After quality control procedures 2,589 subjects with Toronto Scale 20 (TAS-20) data and interview-based information on major depressive disorder (MDD) available. exclusion study participants older...
The mechanism of how childhood trauma leads to increased risk for adult dissociation is not sufficiently understood. We sought investigate the predicting effects and putatively mediating roles PTSD alexithymia on path from dissociation.A total 666 day-clinic outpatients were administered Childhood Trauma Questionnaire (CTQ), Toronto Alexithymia Scale (TAS-20), Posttraumatic Diagnostic (PDS), Dissociative Experiences (DES) controlled sex, age, Global Symptom Index (GSI). Linear regression...
Abstract The brain-derived neurotrophic factor (BDNF) is a neuronal growth essential for normal cardiac contraction and relaxation. Alterations in BDNF signaling are related to the development of cardiovascular disease. Whether subclinical remodeling unclear. We with echocardiographic parameters NTproBNP large population-based cohort (n = 2,976, median age 48 years; 45% male). Transthoracic echocardiography was performed on all subjects measured by ELISA. Study participants severe kidney...
Previous studies have aimed to identify subtypes of obsessive-compulsive disorder (OCD) based on their age onset (AOO). Obsessive-compulsive spectrum disorders (OCS disorders) such as tic been particularly associated with an early in some studies. However, early- and late-onset OCD are unevenly determined, the biological clinical validity these unknown. This study was undertaken discriminate different AOO levels test hypothesis that bands a differential pattern comorbidity.Two hundred...
Abstract Introduction We sought to investigate associations of regional white matter hyperintensities (WMHs) within (WM) tracts with cardiovascular risk and brain aging‐related atrophy throughout adulthood in the general population, leveraging state art pattern analysis methods. Methods analyzed a large sample (n = 2367) from Study Health Pomerania, Germany (range 20–90 years). WMHs were automatically segmented on T1‐weighted fluid‐attenuated inversion recovery magnetic resonance images, WMH...
<h3>BACKGROUND AND PURPOSE:</h3> The presence of the <i>apolipoprotein E</i> ε<i>4</i> allele is strongest sporadic Alzheimer disease genetic risk factor. We hypothesized that carriers and noncarriers may already differ in imaging patterns midlife. therefore sought to identify effect genotype on brain atrophy across almost entire adult age span by using advanced MR imaging–based pattern analysis. <h3>MATERIALS METHODS:</h3> analyzed scans 1472 participants from Study Health Pomerania (22–90...
Abstract Telemedicine for the treatment of depression and anxiety disorders was found to be successful in a randomised controlled trial (RCT); this intervention then implemented routine care Western Pomerania region Germany. This made it possible investigate effectiveness under conditions compare with results RCT. For retrospective analysis, data from (2011–2022) were analysed together previous RCT (2009–2010). A three-arm comparison (routine care, group, control group) on primary outcome...