A5002985304- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Mental Health Research Topics
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Stress Responses and Cortisol
- Heart Rate Variability and Autonomic Control
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience and Neuropharmacology Research
- Sexual function and dysfunction studies
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Vagus Nerve Stimulation Research
- Eating Disorders and Behaviors
- Neurotransmitter Receptor Influence on Behavior
- Child Abuse and Trauma
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Evolutionary Psychology and Human Behavior
Jena University Hospital
2019-2025
Leibniz Institute for Neurobiology
2016-2025
University of Tübingen
2016-2025
Otto-von-Guericke University Magdeburg
2015-2024
Center for Behavioral Brain Sciences
2013-2024
Max Planck Institute for Biological Cybernetics
2012-2024
Trinity College Dublin
2024
Inter-American Development Bank
2023
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2017-2023
Friedrich Schiller University Jena
2019-2023
Although it is being successfully implemented for exploration of the genome, discovery science has eluded functional neuroimaging community. The core challenge remains development common paradigms interrogating myriad systems in brain without constraints a priori hypotheses. Resting-state MRI (R-fMRI) constitutes candidate approach capable addressing this challenge. Imaging during rest reveals large-amplitude spontaneous low-frequency (<0.1 Hz) fluctuations fMRI signal that are temporally...
Immune dysfunction, including monocytosis and increased blood levels of interleukin-1, interleukin-6 tumour necrosis factor α has been observed during acute episodes major depression. These peripheral immune processes may be accompanied by microglial activation in subregions the anterior cingulate cortex where depression-associated alterations glutamatergic neurotransmission have described. Microglial immunoreactivity N-methyl-D-aspartate (NMDA) glutamate receptor agonist quinolinic acid...
Evidence for symptomatic convergence of schizophrenia and N-methyl-D-aspartate glutamate receptor (NMDA-R) encephalitis highlights the need an assessment antibody prevalence specificity distinct disease mechanisms in patients with a diagnosis among glutamatergic pathophysiologic abnormalities psychiatric disorders.To compare NMDA-R antibodies (DSM-IV criteria) those other diagnoses to determine whether subtypes characterize overlap distinction from encephalitis.Serum 459 admitted acute...
Alterations in white matter (WM) microstructure have been implicated the pathophysiology of major depressive disorder (MDD). However, previous findings inconsistent, partially due to low statistical power and heterogeneity depression. In largest multi-site study date, we examined WM anisotropy diffusivity 1305 MDD patients 1602 healthy controls (age range 12–88 years) from 20 samples worldwide, which included both adults adolescents, within Working Group Enhancing Neuroimaging Genetics...
<h3>Context</h3> Major depressive disorder (MDD) is characterized by diverse metabolic and functional abnormalities that occur in, among other regions, the pregenual anterior cingulate cortex (pgACC), a cortical region linked to anhedonia. <h3>Objectives</h3> To contextualize metabolic, functional, clinical parameters thus reveal cellular mechanisms related <h3>Design</h3> The pgACC was investigated using combined magnetic resonance imaging spectroscopic approach. Negative blood oxygenation...
The topic of investigating how mindfulness meditation training can have antidepressant effects via plastic changes in both resting state and brain activity is important the rapidly emerging field neuroplasticity. In present study, we used a longitudinal design fMRI before after 40 days 13 novices. After training, compared differences network connectivity between rest using common functional methods. Interregional methods were paired with local measures such as Regional Homogeneity. As...
Glutamatergic mechanisms and resting-state functional connectivity alterations have been recently described as factors contributing to major depressive disorder (MDD). Furthermore, the pregenual anterior cingulate cortex (pgACC) seems play an important role for symptoms such anhedonia impaired emotion processing. We investigated 22 MDD patients healthy subjects using a combined magnetic resonance spectroscopy (MRS) imaging (fMRI) approach. Severity of depression was rated 21-item Hamilton...
Increasing preclinical and clinical evidence underscores the strong rapid antidepressant properties of glutamate-modulating NMDA receptor antagonist ketamine. Targeting glutamatergic system might thus provide a novel molecular strategy for treatment. Since glutamate is most abundant major excitatory neurotransmitter in brain, pathophysiological changes signaling are likely to affect neurobehavioral plasticity, information processing large-scale functional brain connectivity underlying...
The promise of machine learning has fueled the hope for developing diagnostic tools psychiatry. Initial studies showed high accuracy identification major depressive disorder (MDD) with resting-state connectivity, but progress been hampered by absence large datasets. Here we used regular and advanced deep algorithms to differentiate patients MDD from healthy controls identify neurophysiological signatures depression in two largest datasets MDD. We obtained functional magnetic resonance...
The amygdala is often found to be abnormally recruited in social anxiety disorder (SAD) patients. question whether activation primarily abnormal and affects other brain systems or it responds "normally" an pattern of information conveyed by structures remained unanswered. To address this question, we investigated a network effective connectivity associated with the using Granger causality analysis on resting-state functional MRI data 22 SAD patients 21 healthy controls (HC). Implications...
Major depression is a prevalent disorder that imposes significant burden on society, yet objective laboratory-style tests to assist in diagnosis are lacking. We employed network-based analyses of “resting state” functional neuroimaging data ascertain group differences the endogenous cortical activity between healthy and depressed subjects. additionally sought use machine learning techniques explore ability these measures resting state provide diagnostic information for depression. Resting...
Our sense of self is strongly colored by emotions although at the same time we are well able to distinguish affect and self. Using functional magnetic resonance imaging, here tested for differential effects self-relatedness emotion dimensions (valence, intensity) on parametric modulation neural activity during perception emotional stimuli. We observed opposite in dorsomedial prefrontal cortex ventral striatum/nucleus accumbens, whereas subcortical regions (tectum, right amygdala,...