A5010173959- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Neural dynamics and brain function
- Memory Processes and Influences
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Spatial Cognition and Navigation
- Cognitive Abilities and Testing
- Optical Imaging and Spectroscopy Techniques
- Cognitive Functions and Memory
- Visual and Cognitive Learning Processes
- Child and Animal Learning Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Traumatic Brain Injury and Neurovascular Disturbances
- Mental Health Research Topics
- Cognitive and developmental aspects of mathematical skills
- Visual perception and processing mechanisms
- Dementia and Cognitive Impairment Research
- Heart Rate Variability and Autonomic Control
- Face Recognition and Perception
- Neurobiology of Language and Bilingualism
- Cognitive Science and Mapping
The University of Texas at Dallas
2015-2024
The University of Texas Southwestern Medical Center
2013-2023
Southwestern Medical Center
2019-2023
The University of Texas at Austin
2012-2015
Rutgers, The State University of New Jersey
2002-2007
Rutgers New Jersey Medical School
2006
Stanford University
1999-2001
University of California, Berkeley
2000-2001
University of Pennsylvania
1998-1999
California University of Pennsylvania
1999
Although it is being successfully implemented for exploration of the genome, discovery science has eluded functional neuroimaging community. The core challenge remains development common paradigms interrogating myriad systems in brain without constraints a priori hypotheses. Resting-state MRI (R-fMRI) constitutes candidate approach capable addressing this challenge. Imaging during rest reveals large-amplitude spontaneous low-frequency (<0.1 Hz) fluctuations fMRI signal that are temporally...
Two experiments assess adult age differences in the extent of inhibition or negative priming generated a selective-attention task. Younger adults consistently demonstrated effects; they were slower to name letter on current trial that had served as distractor previous relative one not occurred trial. Whether dissipated when response stimulus interval was lengthened from 500 ms Experiment 1 1,200 2 depended upon whether young subjects aware patterns across types. Older did show at either...
Using an event-related functional MRI design, we explored the relative roles of dorsal and ventral prefrontal cortex (PFC) regions during specific components (Encoding, Delay, Response) a working memory task under different memory-load conditions. In group analysis, effects increased load were observed only in PFC encoding period. Activity was lateralized to right hemisphere high but not low condition. Individual analyses revealed variability activation patterns across subjects. Regression...
The use of functional neuroimaging to test hypotheses regarding age-related changes in the neural substrates cognitive processes relies on assumptions coupling activity signal. Differences signal response between young and elderly subjects can be mapped directly differences only if such does not change with age. Here we examined spatial temporal characteristics BOLD fMRI hemodynamic primary sensorimotor cortex during performance a simple reaction time task. We found that 75% (n = 20)...
Abstract Brain imaging and behavioral studies of working memory (WM) converge to suggest that the ventrolateral prefrontal cortex (PFC) mediates a capacity-limited storage buffer dorsolateral PFC organization processes support supracapacity storage. Previous research from our laboratory has shown extent which such are required depends on both task factors (i.e., load) subject response speed). Task exert their effects mainly during WM encoding while retrieval. In this study, we sought test...
A number of spatial reasoning problems can be solved by performing an imagined transformation one’s egocentric perspective. series experiments were carried out to characterize this process behaviorally and in terms its brain basis, using functional magnetic resonance imaging (fMRI). In a task contrast designed isolate perspective transformations, participants slower make left-right judgments about human figure from the figure’s than their own. This led increased cortical activity around left...
Aerobic exercise (AE) has recently received increasing attention in the prevention of Alzheimer's disease (AD). There is some evidence that it can improve neurocognitive function elderly individuals. However, mechanism these improvements not completely understood. In this prospective c linical trial, thirty amnestic mild cognitive impairment participants were enrolled into two groups and underwent 12 months intervention. One group (n = 15) performed AE training (8M/7F, age 66.4 years),...
Working memory (WM) declines with advancing age. Brain imaging studies indicate that ventral prefrontal cortex (PFC) is active when information retained in WM and dorsal PFC further activated for retention of large amounts information. The authors examined the effect aging on activation specific regions during performance. Six younger 6 older adults performed a task which, each trial, they (a) encoded 1- or 6-letter set, (b) maintained these letters over 5-s. (c) determined whether not probe...
Although it is known that processing speed deficits are one of the primary cognitive impairments in multiple sclerosis (MS), underlying neural mechanisms responsible for impaired remain undetermined. Using BOLD functional magnetic resonance imaging, current study compared brain activity 16 individuals with MS to 17 healthy controls (HCs) during performance a task, modified version Symbol Digit Modalities Task. there were no differences accuracy, group was significantly slower than HCs. both...
Functional magnetic resonance imaging signals, in addition to reflecting neuronal response, also contain physiological variances. These factors may introduce variability into blood oxygen level–dependent (BOLD) activation results, particularly different population groups. In this study, we hypothesized that the amplitude as well spatial extent of BOLD could be improved after minimizing variance caused by neurovascular and anatomical factors. Subjects were scanned while they performed finger...